Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment

Exosome levels in human body fluids: A tumor marker by themselves?

(2017) Francesco Cappello et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation

(2017) Ying Qu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

(2017) Peiming Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex ( CubipyOXA ) leads to cell death in NCI-H292 cancer cells

(2017) Celeste Caruso Bavisotto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

(2017) Haiyang Zhang et al.   Nature Communications

Clinical and biological significance of circulating tumor cells, circulating tumor DNA, and exosomes as biomarkers in colorectal cancer

(2017) Shiyu Jia et al.   Oncotarget

Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal

(2017) Xu Sun et al.   Oncotarget

Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

(2017) Shi-Cong Tao et al.   Theranostics

Exosomes Isolated from Ascites of T-Cell Lymphoma-Bearing Mice Expressing Surface CD24 and HSP-90 Induce a Tumor-Specific Immune Response

(2017) Florencia Menay et al.   Frontiers in Immunology

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

(2017) Elisabetta Vulpis et al.   OncoImmunology

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

(2016) Stefano Fais et al.   ACS Nano

Targeting Hsp70: A possible therapy for cancer

(2016) Sanjay Kumar et al.   CANCER LETTERS

TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

(2016) L. Rivoltini et al.   CLINICAL CANCER RESEARCH

Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers

(2016) Oscar A. Tovar-Camargo et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heat shock proteins and their immunomodulatory role in inflammatory arthritis

(2016) Julia Spierings et al.   RHEUMATOLOGY

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells

(2016) Sandra Pinet et al.   Oncotarget

Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery

(2015) Claudia Campanella et al.   CANCER

Extracellular vesicles shuffling intercellular messages: for good or for bad

(2015) Alessandra Lo Cicero et al.   CURRENT OPINION IN CELL BIOLOGY

The potential of tumor-derived exosomes for noninvasive cancer monitoring

(2015) Theresa L Whiteside   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Cell-derived extracellular vesicles as a platform to identify low-invasive disease biomarkers

(2015) Esperanza González et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation

(2015) Tsutomu Tanaka et al.   IMMUNOLOGY LETTERS

HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms

(2015) Margaux Sevin et al.   MEDIATORS OF INFLAMMATION

The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells

(2015) Claudia Campanella et al.   Oncotarget

Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation

(2015) Ying Zhao et al.   Scientific Reports

Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells

(2015) C Campanella et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Extracellular vesicles as a platform for ‘liquid biopsy’ in glioblastoma patients

(2014) David R Santiago-Dieppa et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages

(2014) V. L. Vega et al.   JOURNAL OF IMMUNOLOGY

Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations

(2014) Silvia Vilasi et al.   PLoS One

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

(2014) Marie Lundholm et al.   PLoS One

Characterization of Uptake and Internalization of Exosomes by Bladder Cancer Cells

(2014) Carrie A. Franzen et al.   Biomed Research International

Cardiac myocyte exosomes: stability, HSP60, and proteomics

(2013) Z. A. Malik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exosomes: the future of biomarkers in medicine

(2013) Francesca Properzi et al.   Biomarkers in Medicine

Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis

(2013) Antonella Marino Gammazza et al.   CELL STRESS & CHAPERONES

The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome

(2013) Eliana A. P. Nahas et al.   CELL STRESS & CHAPERONES

Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design

(2013) Andrea Pace et al.   CURRENT PHARMACEUTICAL DESIGN

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

(2013) Francesco Cappello et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hsp60 and human aging: Les liaisons dangereuses 

(2013) Francesco Cappello   Frontiers in Bioscience-Landmark

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Extracellular Heat Shock Proteins

(2013) Antonio De Maio et al.   SHOCK

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study

(2012) Manfredi Rizzo et al.   CELL STRESS & CHAPERONES

Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in Cancer: Potential Benefits and Risks

(2012) Francesco Cappello et al.   CURRENT PHARMACEUTICAL DESIGN

HSP60 as a Drug Target

(2012) Hiroyuki Nakamura et al.   CURRENT PHARMACEUTICAL DESIGN

HSP60 is transported through the secretory pathway of 3-MCA-induced fibrosarcoma tumour cells and undergoes N-glycosylation

(2012) Dana Hayoun et al.   FEBS Journal

Modulation of heat shock proteins during macrophage differentiation

(2012) Paolo Fagone et al.   INFLAMMATION RESEARCH

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Odyssey of Hsp60 from Tumor Cells to Other Destinations Includes Plasma Membrane-Associated Stages and Golgi and Exosomal Protein-Trafficking Modalities

(2012) Claudia Campanella et al.   PLoS One

Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets?

(2011) Ashraf A. Khalil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Convergent Sets of Data from In Vivo and In Vitro Methods Point to an Active Role of Hsp60 in Chronic Obstructive Pulmonary Disease Pathogenesis

(2011) Francesco Cappello et al.   PLoS One

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors

(2010) Alessandro Allegra et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Hsp60 Is Actively Secreted by Human Tumor Cells

(2010) Anna M. Merendino et al.   PLoS One

Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

(2009) Matteo Landriscina et al.   GYNECOLOGIC ONCOLOGY