Adenomatous Polyposis Coli (APC) in cell migration

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration

(2022) Marta Mastrogiovanni et al.   Science Advances

EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK

(2021) Brice Chanez et al.   Cells

Activity of Arhgef4 is modulated through Staufen1 in neurons

(2021) Kina Lee et al.   NEUROSCIENCE LETTERS

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions

(2021) Xavier Pichon et al.   RNA

GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease

(2021) Daria Hajka et al.   Cells

Axonal mRNA localization and translation: local events with broad roles

(2021) Lichao Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selectivity Determinants of RHO GTPase Binding to IQGAPs

(2021) Niloufar Mosaddeghzadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-molecule imaging of IQGAP1 regulating actin filament dynamics

(2021) Gregory J. Hoeprich et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate

(2021) Yueh-Fu O. Wu et al.   PLoS One

The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1)

(2020) Anan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs

(2020) Sebastian Baumann et al.   Science Advances

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion

(2020) Nadia Efimova et al.   JOURNAL OF CELL BIOLOGY

EB1 Directly Regulates APC-Mediated Actin Nucleation

(2020) Maria Angeles Juanes et al.   CURRENT BIOLOGY

Collective cancer cell invasion requires RNA accumulation at the invasive front

(2020) George Chrisafis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin

(2020) Tanne van der Wal et al.   Open Biology

Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC

(2019) Jing Yuan How et al.   FEBS LETTERS

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC–Asef interaction

(2019) Xiao-Qiang Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Adenomatous Polyposis Coli as a Scaffold for Microtubule End-Binding Proteins

(2019) Laurence Serre et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of APC-mediated actin assembly in microtubule capture and focal adhesion turnover

(2019) M. Angeles Juanes et al.   JOURNAL OF CELL BIOLOGY

Generation and regulation of microtubule network asymmetry to drive cell polarity

(2019) Joyce C.M. Meiring et al.   CURRENT OPINION IN CELL BIOLOGY

Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units

(2018) Lorna E. Young et al.   CURRENT BIOLOGY

Branched actin networks push against each other at adherens junctions to maintain cell–cell adhesion

(2018) Nadia Efimova et al.   JOURNAL OF CELL BIOLOGY

Truncated APC Mutation Induces Asef Activated Golgi Fragmentation

(2018) Sang Bum Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

The Actin Cytoskeleton and Actin-Based Motility

(2018) Tatyana Svitkina   Cold Spring Harbor Perspectives in Biology

APC2 controls dendrite development by promoting microtubule dynamics

(2018) Olga I. Kahn et al.   Nature Communications

Expression and Manipulation of the APC-β-Catenin Pathway During Peripheral Neuron Regeneration

(2018) Arul Duraikannu et al.   Scientific Reports

Actin–microtubule crosstalk in cell biology

(2018) Marileen Dogterom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial Membrane Protein 2 and β1 integrin signaling regulate APC-mediated processes

(2017) Alyssa C. Lesko et al.   EXPERIMENTAL CELL RESEARCH

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

(2017) M. Angeles Juanes et al.   JOURNAL OF CELL BIOLOGY

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein

(2017) Feng J. Gao et al.   MOLECULAR BIOLOGY OF THE CELL

Peptidomimetic inhibitors of APC–Asef interaction block colorectal cancer migration

(2017) Haiming Jiang et al.   Nature Chemical Biology

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

(2017) Tianhong Wang et al.   Nature Communications

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

(2017) Sonia Agüera-González et al.   Cell Reports

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals

(2016) Barbara Lupo et al.   BMC BIOLOGY

Actin filament-microtubule interactions in axon initiation and branching

(2016) Almudena Pacheco et al.   BRAIN RESEARCH BULLETIN

Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance

(2016) Garrett M. Cammarata et al.   Cytoskeleton

APC functions at the centrosome to stimulate microtubule growth

(2016) Christina Lui et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

(2016) Peter T. Ruane et al.   Scientific Reports

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis

(2015) Alyssa C. Lesko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

(2015) Takashi Watanabe et al.   CELL STRUCTURE AND FUNCTION

The Guanine Nucleotide Exchange Factor (GEF) Asef2 Promotes Dendritic Spine Formation via Rac Activation and Spinophilin-dependent Targeting

(2015) J. Corey Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis

(2015) Satya Narayan et al.   LIFE SCIENCES

IQGAP1: Insights into the function of a molecular puppeteer

(2015) Alex M. Abel et al.   MOLECULAR IMMUNOLOGY

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promoting microtubule assembly: A hypothesis for the functional significance of the+TIP network

(2014) Kamlesh K. Gupta et al.   BIOESSAYS

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

(2014) Nicolas Preitner et al.   CELL

Exploiting APC Function as a Novel Cancer Therapy

(2014) Alyssa Lesko et al.   CURRENT DRUG TARGETS

Differential Regulation of Microtubule Severing by APC Underlies Distinct Patterns of Projection Neuron and Interneuron Migration

(2014) Tae-Yeon Eom et al.   DEVELOPMENTAL CELL

Hepatocyte Growth Factor-induced Asef-IQGAP1 Complex Controls Cytoskeletal Remodeling and Endothelial Barrier

(2014) Yufeng Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

(2014) Ezgi Kunttas-Tatli et al.   MOLECULAR BIOLOGY OF THE CELL

Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities

(2014) J L Mohn et al.   MOLECULAR PSYCHIATRY

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

(2014) Takanori Onouchi et al.   Molecular Brain

Familial adenomatous polyposis in an adolescent with coexisting schizophrenia: treatment strategies and implications

(2014) Luisa Gonzalez et al.   Molecular Genetics & Genomic Medicine

Microtubules in Cell Migration

(2013) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology

(2013) Matthew A Odenwald et al.   BMC CANCER

Differences in the localization of the adenomatous polyposis coli-Asef/Asef2 complex between adenomatous polyposis coli wild-type and mutant cells

(2013) Yoshihiro Kawasaki et al.   CANCER SCIENCE

IQGAP1 interactome analysis by in vitro reconstitution and live cell 3-color FRET microscopy

(2013) Horst Wallrabe et al.   Cytoskeleton

IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration

(2013) Suyong Choi et al.   EMBO JOURNAL

APC binds intermediate filaments and is required for their reorganization during cell migration

(2013) Yasuhisa Sakamoto et al.   JOURNAL OF CELL BIOLOGY

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

(2013) Kyota Yasuda et al.   JOURNAL OF CELL BIOLOGY

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance

(2013) S. Nelson et al.   JOURNAL OF CELL SCIENCE

Adenomatous Polyposis Coli Regulates Oligodendroglial Development

(2013) J. Lang et al.   JOURNAL OF NEUROSCIENCE

Correction: Kif3a Guides Microtubular Dynamics, Migration and Lumen Formation of MDCK Cells

(2013) Christopher Boehlke et al.   PLoS One

Mammalian Diaphanous-Related Formin 1 Regulates GSK3β-Dependent Microtubule Dynamics Required for T Cell Migratory Polarization

(2013) Baoxia Dong et al.   PLoS One

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins

(2012) Kai Jiang et al.   CURRENT BIOLOGY

Amer2 Protein Interacts with EB1 Protein and Adenomatous Polyposis Coli (APC) and Controls Microtubule Stability and Cell Migration

(2012) Astrid S. Pfister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-activated protein kinase (MAPK/ERK) regulates adenomatous polyposis coli during growth-factor-induced cell extension

(2012) H. Y. Caro-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Dock3 Stimulates Axonal Outgrowth via GSK-3 -Mediated Microtubule Assembly

(2012) K. Namekata et al.   JOURNAL OF NEUROSCIENCE

Directional Neuronal Migration Is Impaired in Mice Lacking Adenomatous Polyposis Coli 2

(2012) T. Shintani et al.   JOURNAL OF NEUROSCIENCE

Rocket Launcher Mechanism of Collaborative Actin Assembly Defined by Single-Molecule Imaging

(2012) D. Breitsprecher et al.   SCIENCE

Structural basis for the recognition of Asef by adenomatous polyposis coli

(2011) Zhenyi Zhang et al.   CELL RESEARCH

Aurora B Regulates Formin mDia3 in Achieving Metaphase Chromosome Alignment

(2011) Lina Cheng et al.   DEVELOPMENTAL CELL

Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila

(2011) M.-N. Zhou et al.   JOURNAL OF CELL SCIENCE

BDNF-Induced Increase of PSD-95 in Dendritic Spines Requires Dynamic Microtubule Invasions

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

(2011) Thomas W. Marshall et al.   MOLECULAR BIOLOGY OF THE CELL

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

(2011) David P Minde et al.   Molecular Cancer

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fifteen formins for an actin filament: A molecular view on the regulation of human formins

(2010) André Schönichen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends

(2010) Niels Galjart   CURRENT BIOLOGY

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse

(2010) Rémi Lasserre et al.   EMBO JOURNAL

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

(2010) Shinji Matsumoto et al.   EMBO JOURNAL

KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC

(2010) Fanny Jaulin et al.   JOURNAL OF CELL BIOLOGY

Cdc42 localization and cell polarity depend on membrane traffic

(2010) Naël Osmani et al.   JOURNAL OF CELL BIOLOGY

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

(2010) Kyoko Okada et al.   JOURNAL OF CELL BIOLOGY

LKB1-Mediated Spatial Control of GSK3  and Adenomatous Polyposis Coli Contributes to Centrosomal Forward Movement and Neuronal Migration in the Developing Neocortex

(2010) N. Asada et al.   JOURNAL OF NEUROSCIENCE

Adenomatous Polyposis Coli Regulates Endothelial Cell Migration Independent of Roles in β-Catenin Signaling and Cell–Cell Adhesion

(2010) Elizabeth S. Harris et al.   MOLECULAR BIOLOGY OF THE CELL

Independent Interactions of Phosphorylated β-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions

(2010) Maree C. Faux et al.   PLoS One

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells

(2010) K. Zaoui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel association of APC with intermediate filaments identified using a new versatile APC antibody

(2009) Yang Wang et al.   BMC CELL BIOLOGY

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

The Mitochondrial Protein hTID-1 Partners With the Caspase-Cleaved Adenomatous Polyposis Cell Tumor Suppressor to Facilitate Apoptosis

(2009) Jiang Qian et al.   GASTROENTEROLOGY

Adenomatous Polyposis Coli and Asef Function Downstream of Hepatocyte Growth Factor and Phosphatidylinositol 3-Kinase

(2009) Yoshihiro Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nup358 interacts with APC and plays a role in cell polarization

(2009) P. Murawala et al.   JOURNAL OF CELL SCIENCE

APC2 Plays an Essential Role in Axonal Projections through the Regulation of Microtubule Stability

(2009) T. Shintani et al.   JOURNAL OF NEUROSCIENCE

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

(2009) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

The Adenomatous Polyposis Coli Protein Is an Essential Regulator of Radial Glial Polarity and Construction of the Cerebral Cortex

(2009) Yukako Yokota et al.   NEURON

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Cell regulation by the Apc protein

(2008) Brooke M McCartney et al.   CURRENT OPINION IN CELL BIOLOGY

The role of the cytoskeleton during neuronal polarization

(2008) Harald Witte et al.   CURRENT OPINION IN NEUROBIOLOGY

Identification of a Link between the SAMP Repeats of Adenomatous Polyposis Coli Tumor Suppressor and the Src Homology 3 Domain of DDEF

(2008) Chiyuki Matsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?

(2008) Nasser M. Rusan et al.   JOURNAL OF CELL BIOLOGY

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

(2008) Francesca Bartolini et al.   JOURNAL OF CELL BIOLOGY

Novel self-association of the APC molecule affects APC clusters and cell migration

(2008) Z. Li et al.   JOURNAL OF CELL SCIENCE

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

(2008) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Microtubules in Dendritic Spine Development

(2008) J. Gu et al.   JOURNAL OF NEUROSCIENCE

Arp2/3 Complex Is Important for Filopodia Formation, Growth Cone Motility, and Neuritogenesis in Neuronal Cells

(2008) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE