Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

(2010) Kyoko Okada et al.   JOURNAL OF CELL BIOLOGY

Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators

(2010) Joseph A. Marsh et al.   STRUCTURE

Direct Observation of the Dynamic Process Underlying Allosteric Signal Transmission

(2009) Sven Brüschweiler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity

(2009) Caroline Lund Dahlberg et al.   PLoS One

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer

(2008) Karim Bougatef et al.   CANCER GENETICS AND CYTOGENETICS

Cell regulation by the Apc protein

(2008) Brooke M McCartney et al.   CURRENT OPINION IN CELL BIOLOGY

Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: Evidence for Wnt pathway implication

(2008) Efstathios Kastritis et al.   INTERNATIONAL JOURNAL OF CANCER

The Structure and Interactions of the Proline-rich Domain of ASPP2

(2008) Shahar Rotem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE