Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals

ATM controls proper mitotic spindle structure

(2014) Luca Palazzo et al.   CELL CYCLE

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

Microtubules in Cell Migration

(2013) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics

(2013) A. Molina et al.   CANCER RESEARCH

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

EphA2 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells

(2013) J Huang et al.   ONCOGENE

Kinetic stabilization of microtubule dynamics by indanocine perturbs EB1 localization, induces defects in cell polarity and inhibits migration of MDA-MB-231 cells

(2012) Sonia Kapoor et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Tankyrase 1 regulates centrosome function by controlling CPAP stability

(2012) Mi Kyung Kim et al.   EMBO REPORTS

Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation

(2012) Yuko Ozaki et al.   MOLECULAR CELL

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

(2012) Renyue Bao et al.   PLoS One

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

(2011) Sebastian Guettler et al.   CELL

Orientation and function of the nuclear–centrosomal axis during cell migration

(2011) GW Gant Luxton et al.   CURRENT OPINION IN CELL BIOLOGY

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors

(2011) Davide Torti et al.   INTERNATIONAL JOURNAL OF CANCER

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor

(2010) Tobias Karlberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly

(2009) Paul Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer

(2009) N McCabe et al.   ONCOGENE

Polarity proteins in migration and invasion

(2008) S Etienne-Manneville   ONCOGENE