Harnessing the ubiquitin code to respond to environmental cues

Beyond K48 and K63: non-canonical protein ubiquitination

(2021) Michal Tracz et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination

(2021) Dongsheng Yao et al.   Molecular Plant

Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase

(2021) Yasuhiro Fuseya et al.   Cells

TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1

(2021) Milton Roy et al.   CELLULAR SIGNALLING

Recruitment of Ubiquitin within an E2 Chain Elongation Complex

(2020) Benjamin W. Cook et al.   BIOPHYSICAL JOURNAL

Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders

(2020) Daisuke Oikawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

(2020) Raquel C. Martinez-Chacin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Advances on Plant Ubiquitylome—From Mechanism to Application

(2020) Dongli He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

(2020) Suchitra Mohanty et al.   PLoS Pathogens

HECT E3 Ligases: A Tale With Multiple Facets

(2019) Janine Weber et al.   Frontiers in Physiology

Enzymatic Logic of Ubiquitin Chain Assembly

(2019) Kirandeep K. Deol et al.   Frontiers in Physiology

Advanced Cataloging of Lysine-63 Polyubiquitin Networks by Genomic, Interactome, and Sensor-based Proteomic Analyses

(2019) Natali Romero-Barrios et al.   PLANT CELL

Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1

(2019) Andrew J. Boughton et al.   STRUCTURE

Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1

(2019) Michael J Skelly et al.   eLife

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

(2018) Kuan-Chuan Pao et al.   NATURE

RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

(2018) Helen Walden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

(2018) Wolfgang Dubiel et al.   TRENDS IN BIOCHEMICAL SCIENCES

RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

(2018) Helen Walden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes

(2018) Domingo Jiménez-López et al.   PLoS One

Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity

(2018) James J. Furniss et al.   PLoS Pathogens

In silicomodeling of the cryptic E2∼ubiquitin–binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly

(2017) Virginia P. Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase

(2017) Michael E. French et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

(2017) Martin A. Michel et al.   MOLECULAR CELL

Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

(2017) Chao Liu et al.   Nature Communications

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms

(2016) Katja K Dove et al.   EMBO REPORTS

Arabidopsis ubiquitin-conjugating enzyme UBC22 is required for female gametophyte development and likely involved in Lys11-linked ubiquitination

(2016) Sheng Wang et al.   JOURNAL OF EXPERIMENTAL BOTANY

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

(2016) Fumiaki Ohtake et al.   MOLECULAR CELL

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

(2015) Yosua Adi Kristariyanto et al.   MOLECULAR CELL

Structural and Functional Insights to Ubiquitin-Like Protein Conjugation

(2014) Frederick C. Streich et al.   Annual Review of Biophysics

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

Ubiquitin acetylation inhibits polyubiquitin chain elongation

(2014) F. Ohtake et al.   EMBO REPORTS

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

(2014) Francesca Mattiroli et al.   Nature Communications

Functional implications of K63-linked ubiquitination in the iron deficiency response of Arabidopsis roots

(2014) I-Chun Pan et al.   Frontiers in Plant Science

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Following Ariadne's thread: a new perspective on RBR ubiquitin ligases

(2013) Dawn M Wenzel et al.   BMC BIOLOGY

The Tomato Fni3 Lysine-63-Specific Ubiquitin-Conjugating Enzyme and Suv Ubiquitin E2 Variant Positively Regulate Plant Immunity

(2013) R. V. Mural et al.   PLANT CELL

Advanced Proteomic Analyses Yield a Deep Catalog of Ubiquitylation Targets inArabidopsis

(2013) Do-Young Kim et al.   PLANT CELL

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Selectivity of the ubiquitin-binding modules

(2012) Simin Rahighi et al.   FEBS LETTERS

Ubiquitin-Mediated Control of Plant Hormone Signaling

(2012) D. R. Kelley et al.   PLANT PHYSIOLOGY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Ubiquitination of Substrates by Esterification

(2011) Xiaoli Wang et al.   TRAFFIC

A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells

(2010) Frederic Galisson et al.   MOLECULAR & CELLULAR PROTEOMICS

The Diversity of Ubiquitin Recognition: Hot Spots and Varied Specificity

(2010) Jason M. Winget et al.   MOLECULAR CELL

Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate

(2010) Kenneth Wu et al.   MOLECULAR CELL

Proteasome-Mediated Turnover of the Transcription Coactivator NPR1 Plays Dual Roles in Regulating Plant Immunity

(2009) Steven H. Spoel et al.   CELL

Polyubiquitin Binding and Disassembly By Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   CHEMICAL REVIEWS

The Structure and Conformation of Lys63-Linked Tetraubiquitin

(2009) Ajit B. Datta et al.   JOURNAL OF MOLECULAR BIOLOGY

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Arabidopsis UEV1D Promotes Lysine-63-Linked Polyubiquitination and Is Involved in DNA Damage Response

(2008) R. Wen et al.   PLANT CELL