Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Targeted protein degradation: elements of PROTAC design

(2019) Stacey-Lynn Paiva et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome (APC/C) activity resulting in microcephaly, psychomotor retardation and epilepsy

(2019) Cristina Rodríguez et al.   JOURNAL OF NEUROCHEMISTRY

Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains

(2019) Diane L. Haakonsen et al.   TRENDS IN CELL BIOLOGY

Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates

(2018) Thomas Bonacci et al.   EMBO JOURNAL

Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics

(2018) Sophie Moggridge et al.   JOURNAL OF PROTEOME RESEARCH

Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle

(2018) Jennifer Kernan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

(2018) Edmond R. Watson et al.   TRENDS IN CELL BIOLOGY

Ubiquitylation at the crossroads of development and disease

(2017) Michael Rape   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

(2016) Nicholas G. Brown et al.   CELL

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

A decade of the anaphase-promoting complex in the nervous system

(2016) Ju Huang et al.   GENES & DEVELOPMENT

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity

(2016) Qiuhong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation

(2016) Allison Craney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of APC/CCDC20activation by mitotic phosphorylation

(2016) Renping Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase

(2016) K. Fujimitsu et al.   SCIENCE

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Structure of an APC3–APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome

(2015) Masaya Yamaguchi et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of the anaphase-promoting complex: A single-molecule study

(2015) Y. Lu et al.   SCIENCE

The Biochemistry of Mitosis

(2015) Samuel Wieser et al.   Cold Spring Harbor Perspectives in Biology

Structural and Functional Insights to Ubiquitin-Like Protein Conjugation

(2014) Frederick C. Streich et al.   Annual Review of Biophysics

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Activation of the APC/C Ubiquitin Ligase by Enhanced E2 Efficiency

(2014) Vanessa A. Van Voorhis et al.   CURRENT BIOLOGY

Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate

(2014) Aileen Kelly et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C

(2014) Kosuke Sako et al.   Nature Communications

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

(2013) Ian R Kelsall et al.   EMBO JOURNAL

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

(2011) E. C. Dueber et al.   SCIENCE

Mutual regulation between the spindle checkpoint and APC/C

(2011) Soonjoung Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate

(2010) Kenneth Wu et al.   MOLECULAR CELL

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

(2010) Paula C. A. da Fonseca et al.   NATURE

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

(2010) Bettina A Buschhorn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates

(2009) Gary Kleiger et al.   CELL

Analysis of Activator-Binding Sites on the APC/C Supports a Cooperative Substrate-Binding Mechanism

(2009) Mary E. Matyskiela et al.   MOLECULAR CELL

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

(2009) Mathew J. Garnett et al.   NATURE CELL BIOLOGY

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL