The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission

Variable histopathology features of neuronal dyslamination in the cerebral neocortex adjacent to epilepsy‐associated vascular malformations suggest complex pathogenesis of focal cortical dysplasia ILAE type IIIc

(2022) Hajime Miyata et al.   BRAIN PATHOLOGY

Imaging characteristics of temporopolar blurring in the context of hippocampal sclerosis

(2022) Carlos Andrés Clavijo Prado et al.   EPILEPTIC DISORDERS

Dysmorphic neurons as cellular source for phase-amplitude coupling in Focal Cortical Dysplasia Type II

(2021) Stefan Rampp et al.   CLINICAL NEUROPHYSIOLOGY

Gradient of brain mosaic RHEB variants causes a continuum of cortical dysplasia

(2021) Wei Shern Lee et al.   Annals of Clinical and Translational Neurology

Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)

(2021) Thomas Bonduelle et al.   Acta Neuropathologica Communications

Detection of Brain Somatic Mutations in Cerebrospinal Fluid from Refractory Epilepsy Patients

(2021) Seyeon Kim et al.   ANNALS OF NEUROLOGY

Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial

(2021) Ingmar Blümcke et al.   EPILEPSIA

Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort

(2021) Vanessa C. Mendes Coelho et al.   EPILEPSIA

Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE): a widespread disease with an apparently focal epilepsy

(2021) Raghavendra Seetharam et al.   EPILEPTIC DISORDERS

One-Stage, Limited-Resection, Epilepsy Surgery for Bottom-of-Sulcus Dysplasia

(2021) Emma Macdonald-Laurs et al.   NEUROLOGY

Application of single cell genomics to focal epilepsies: A call to action

(2021) Sattar Khoshkhoo et al.   BRAIN PATHOLOGY

Focal cortical dysplasia type 1

(2021) Roland Coras et al.   BRAIN PATHOLOGY

Molecular diagnostics in drug‐resistant focal epilepsy define new disease entities

(2021) Katja Kobow et al.   BRAIN PATHOLOGY

Toward a refined genotype–phenotype classification scheme for the international consensus classification of Focal Cortical Dysplasia

(2021) Ingmar Blumcke et al.   BRAIN PATHOLOGY

DNA methylation-based classification of malformations of cortical development in the human brain

(2021) Samir Jabari et al.   ACTA NEUROPATHOLOGICA

Clinical characteristics and postoperative seizure outcome in patients with mild malformation of cortical development and oligodendroglial hyperplasia

(2021) Ahmed Gaballa et al.   EPILEPSIA

ILAE Neuroimaging Task Force Highlight: harnessing optimized imaging protocols for drug-resistant childhood epilepsy

(2021) Sara Larivière et al.   EPILEPTIC DISORDERS

Neocortical development and epilepsy: insights from focal cortical dysplasia and brain tumours

(2021) Ingmar Blumcke et al.   LANCET NEUROLOGY

Low-grade developmental and epilepsy associated brain tumors: a critical update 2020

(2020) Rutger Juriaan Slegers et al.   Acta Neuropathologica Communications

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay

(2020) Katja Kobow et al.   ACTA NEUROPATHOLOGICA

Value of 7T MRI and post‐processing in patients with nonlesional 3T MRI undergoing epilepsy presurgical evaluation

(2020) Irene Wang et al.   EPILEPSIA

MRI essentials in epileptology: a review from the ILAE Imaging Taskforce

(2020) Irene Wang et al.   EPILEPTIC DISORDERS

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

(2020) Herm J Lamberink et al.   LANCET NEUROLOGY

Genetic characterisation identifies bottom-of-sulcus dysplasia as an mTORopathy

(2020) Wei Shern Lee et al.   NEUROLOGY

Mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE): Neurophysiological fingerprints of a new pathological entity

(2020) Roberta Di Giacomo et al.   CLINICAL NEUROPHYSIOLOGY

7T Epilepsy Task Force Consensus Recommendations on the use of 7T in Clinical Practice

(2020) Giske Opheim et al.   NEUROLOGY

Is Focal Cortical Dysplasia/Epilepsy Caused by Somatic MTOR Mutations Always a Unilateral Disorder?

(2020) Renzo Guerrini et al.   Neurology-Genetics

Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia

(2019) Katja Kobow et al.   EPILEPSIA

Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force

(2019) Andrea Bernasconi et al.   EPILEPSIA

Temporal lobe “plus” epilepsy associated with oligodendroglial hyperplasia (MOGHE)

(2019) Kyriakos Garganis et al.   ACTA NEUROLOGICA SCANDINAVICA

Precise detection of low-level somatic mutation in resected epilepsy brain tissue

(2019) Nam Suk Sim et al.   ACTA NEUROPATHOLOGICA

Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

(2019) Sara Baldassari et al.   ACTA NEUROPATHOLOGICA

Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy

(2019) Cristiana Pelorosso et al.   HUMAN MOLECULAR GENETICS

Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy

(2018) Melodie R. Winawer et al.   ANNALS OF NEUROLOGY

Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia–associated epilepsy

(2018) Théo Ribierre et al.   JOURNAL OF CLINICAL INVESTIGATION

Review: The international consensus classification of Focal Cortical Dysplasia - a critical update 2018

(2018) I. M. Najm et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Synaptic plexi of U-fibre layer beneath focal cortical dysplasias: Role in epileptic networks

(2018) Harvey B. Sarnat et al.   CLINICAL NEUROPATHOLOGY

Age-related MR characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE)

(2018) Till Hartlieb et al.   EPILEPSY & BEHAVIOR

MRI, Magnetoencephalography, and Surgical Outcome of Oligodendrocytosis versus Focal Cortical Dysplasia Type I

(2018) D. Mata-Mbemba et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The repertoire of seizure onset patterns in human focal epilepsies: Determinants and prognostic values

(2018) Stanislas Lagarde et al.   EPILEPSIA

Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype‐phenotype analysis

(2018) I. Blümcke et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mild malformations of cortical development in sleep-related hypermotor epilepsy due to KCNT1 mutations

(2018) Guido Rubboli et al.   Annals of Clinical and Translational Neurology

A distinct clinicopathological variant of focal cortical dysplasia IIId characterized by loss of layer 4 in the occipital lobe in 12 children with remote hypoxic-ischemic injury

(2017) Dan-Dan Wang et al.   EPILEPSIA

Comparison of clinical features and surgical outcome in focal cortical dysplasia type 1 and type 2

(2017) Cihan Isler et al.   EPILEPSY RESEARCH

Characteristics of EEG Seizure-Onset Patterns Recorded From Subdural Electrodes Over MRI-Visible Frontal Focal Cortical Dysplasia Type IIb Lesions

(2017) Daisuke Hirozawa et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

(2017) Ingmar Blumcke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias

(2017) Alissa M. D’Gama et al.   Cell Reports

The relationship between morphological lesion, magnetic source imaging, and intracranial stereo-electroencephalography in focal cortical dysplasia

(2017) Romain Bouet et al.   NeuroImage-Clinical

A novel TUBB3 mutation in a sporadic patient with asymmetric cortical dysplasia

(2016) Keiko Shimojima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Frontal Lobe Epilepsy: A New Clinico-Pathological Entity

(2016) Johannes Schurr et al.   BRAIN PATHOLOGY

Seizure-onset patterns in focal cortical dysplasia and neurodevelopmental tumors: Relationship with surgical prognosis and neuropathologic subtypes

(2016) Stanislas Lagarde et al.   EPILEPSIA

International recommendation for a comprehensive neuropathologic workup of epilepsy surgery brain tissue: A consensus Task Force report from the ILAE Commission on Diagnostic Methods

(2016) Ingmar Blümcke et al.   EPILEPSIA

7T MRI in focal epilepsy with unrevealing conventional field strength imaging

(2016) Alessio De Ciantis et al.   EPILEPSIA

Low-grade epilepsy-associated neuroepithelial tumours — the 2016 WHO classification

(2016) Ingmar Blümcke et al.   Nature Reviews Neurology

Surgical treatment of pediatric focal cortical dysplasia

(2016) Hye Eun Kwon et al.   NEUROLOGY

Association ofMTORMutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism

(2016) Ghayda M. Mirzaa et al.   JAMA Neurology

Etiology matters – Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy

(2016) Konrad J. Dębski et al.   Scientific Reports

Somatic Mutations in theMTORgene cause focal cortical dysplasia type IIb

(2015) Mitsuko Nakashima et al.   ANNALS OF NEUROLOGY

Familial focal epilepsy with focal cortical dysplasia due toDEPDC5mutations

(2015) Stéphanie Baulac et al.   ANNALS OF NEUROLOGY

Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia

(2015) Alissa M. D'Gama et al.   ANNALS OF NEUROLOGY

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy

(2015) Karen L. Skjei et al.   Journal of Neurosurgery-Pediatrics

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

The surgically remediable syndrome of epilepsy associated with bottom-of-sulcus dysplasia

(2015) A. S. Harvey et al.   NEUROLOGY

Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR

(2015) R. J. Leventer et al.   NEUROLOGY

A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors

(2014) Ingmar Blumcke et al.   ACTA NEUROPATHOLOGICA

Linking MRI postprocessing with magnetic source imaging in MRI-negative epilepsy

(2014) Zhong I. Wang et al.   ANNALS OF NEUROLOGY

Sturge-Weber Syndrome Is Associated with Cortical Dysplasia ILAE Type IIIc and Excessive Hypertrophic Pyramidal Neurons in Brain Resections for Intractable Epilepsy

(2014) Dan-Dan Wang et al.   BRAIN PATHOLOGY

Severe Neonatal Epileptic Encephalopathy and KCNQ2 Mutation: Neuropathological Substrate?

(2014) Charlotte Dalen Meurs-van der Schoor et al.   Frontiers in Pediatrics

High-throughput, automated quantification of white matter neurons in mild malformation of cortical development in epilepsy

(2014) Joan YW Liu et al.   Acta Neuropathologica Communications

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

(2013) Katja Kobow et al.   ACTA NEUROPATHOLOGICA

Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology

(2013) Piero Perucca et al.   BRAIN

Blurring in patients with temporal lobe epilepsy: clinical, high-field imaging and ultrastructural study

(2012) R. Garbelli et al.   BRAIN

Good interobserver and intraobserver agreement in the evaluation of the new ILAE classification of focal cortical dysplasias

(2012) Roland Coras et al.   EPILEPSIA

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI

(2011) Angelika Mühlebner et al.   ACTA NEUROPATHOLOGICA

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Interobserver and intraobserver reproducibility in focal cortical dysplasia (malformations of cortical development)

(2009) Wendy A. Chamberlain et al.   EPILEPSIA

Temporal Lobe Sclerosis Associated With Hippocampal Sclerosis in Temporal Lobe Epilepsy: Neuropathological Features

(2009) Maria Thom et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY