Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Neurosciences
Frank Neugebauer, Marios Antonakakis, Kanjana Unnwongse, Yaroslav Parpaley, Joerg Wellmer, Stefan Rampp, Carsten H. Wolters
Summary: MEG and EEG source analysis is frequently used for the presurgical evaluation of pharmacoresistant epilepsy patients. In this study, the authors compared the standard dipole scanning method with two beamformer approaches for the inverse problem and investigated the influence of covariance estimation method and regularization strength on localization performance. They found that beamformer localization is sensitive to the choice of the regularization parameter and that estimation of the covariance matrix with averaged spike data yielded more robust results across modalities.
Article
Clinical Neurology
Peter N. Taylor, Christoforos A. Papasavvas, Thomas W. Owen, Gabrielle M. Schroeder, Frances E. Hutchings, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B. Vos, Matthew C. Walker, Yujiang Wang
Summary: This study investigates the detection of interictal abnormalities in intracranial EEG by constructing a normative map of brain dynamics and quantitatively accounting for the range of healthy brain dynamics. The study finds that regions spared by surgery are more abnormal than resected regions, which can differentiate patient outcomes.
Article
Engineering, Biomedical
Jiajie Mo, Jianguo Zhang, Wenhan Hu, Xiaoqiu Shao, Lin Sang, Zhong Zheng, Chao Zhang, Yao Wang, Xiu Wang, Chang Liu, Baotian Zhao, Kai Zhang
Summary: This study investigated the neuroimaging gradient alterations and epileptogenicity of FCD IIIa, along with their potential values in guiding suitable resection range and predicting postoperative seizure outcomes. The conclusions from this study may facilitate an accurate presurgical examination of FCD IIIa. However, further investigation including a larger cohort is necessary to confirm the results.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Rupesh Kumar Chikara, Saeed Jahromi, Eleonora Tamilia, Joseph R. Madsen, Steve M. Stufflebeam, Phillip L. Pearl, Christos Papadelis
Summary: The study aims to evaluate the diagnostic accuracy of electromagnetic source imaging (EMSI) in localizing spikes and predicting surgical outcome in children with drug resistant epilepsy (DRE) due to focal cortical dysplasia (FCD). We analyzed MEG and HD-EEG data from 23 children and compared the localization accuracy and predictive performance of EMSI, ESI, and MSI. The results showed that EMSI had superior localization accuracy and predictive performance compared to individual modalities.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Radek Janca, Petr Jezdik, Matyas Ebel, Adam Kalina, Martin Kudr, Alena Jahodova, David Krysl, Katerina Mackova, Barbora Straka, Petr Marusic, Pavel Krsek
Summary: This study demonstrates that electrophysiological patterns can accurately differentiate FCD types and help predict presurgical MRI findings, providing more precise surgical plans for patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Cell Biology
Huifang E. Wang, Marmaduke Woodman, Paul Triebkorn, Jean-Didier Lemarechal, Jayant Jha, Borana Dollomaja, Anirudh Nihalani Vattikonda, Viktor Sip, Samuel Medina Villalon, Meysam Hashemi, Maxime Guye, Julia Makhalova, Fabrice Bartolomei, Viktor Jirsa
Summary: We propose a virtual epileptic patient (VEP) workflow that uses personalized brain models and machine learning methods to estimate epileptogenic zone networks (EZNs) and aid surgical strategies. By sampling and optimizing personalized model parameters using functional stereoelectroencephalography recordings, the VEP accurately determines a patient's EZN. Additionally, the VEP can predict surgical outcomes using virtual surgeries.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Lipeng Cheng, Yue Xing, Herui Zhang, Ru Liu, Huanling Lai, Yueshan Piao, Wei Wang, Xiaoming Yan, Xiaonan Li, Jiaoyang Wang, Donghong Li, Horace H. Loh, Tao Yu, Guojun Zhang, Xiaofeng Yang
Summary: This study aimed to explore the underlying mechanism of epileptogenesis induced by focal cortical dysplasia (FCD) by examining the micro-macro neuronal network in specific brain regions. The researchers found abnormal expression and distribution of interneurons in the seizure onset zone (SOZ) compared to non-SOZ and mesial temporal lobe epilepsy (mTLE) interneurons. Additionally, pyramidal cells in the SOZ exhibited higher excitation but lower inhibition compared to mTLE controls, suggesting synchronized neuronal activity in the epileptogenic zone (EZ). These findings provide evidence for a potential neurocircuit underlying SOZ epileptogenesis and non-SOZ seizure susceptibility in FCD.
Review
Medicine, General & Internal
Dimitar Metodiev, Krassimir Minkin, Margarita Ruseva, Rumiana Ganeva, Dimitar Parvanov, Sevdalin Nachev
Summary: This article reviews the literature on the morphological changes associated with pharmacoresistant epilepsy, emphasizing the morphological basis in brain tissue. The International League Against Epilepsy (ILAE) has revised the classification of FCD and introduced new histologically defined pathological entities. Although the pathomorphological characteristics of various forms of focal cortical dysplasias are well known, their etiology and pathogenesis remain unclear. The identification of genetic variants in FCD opens up new treatment strategies.
Article
Clinical Neurology
Laura Rossini, Dalia De Santis, Erica Cecchini, Cinzia Cagnoli, Emanuela Maderna, Daniele Cartelli, Bryan Paul Morgan, Megan Torvell, Roberto Spreafico, Roberta di Giacomo, Laura Tassi, Marco de Curtis, Rita Garbelli
Summary: Dendritic spines are crucial for excitatory glutamatergic synapses. The study explores the role of complement components C1q and C3 in synaptic pruning imbalance in Type II focal cortical dysplasia (FCD). The findings provide valuable insights into the understanding and treatment of diseases related to Type II FCD.
Article
Clinical Neurology
Shuai Ye, Anto Bagic, Bin He
Summary: The objective of this study is to extract pathological brain networks from interictal period of E/MEG recordings to localize epileptic foci for presurgical evaluation. We proposed here a resting state E/MEG analysis framework, to disentangle brain functional networks represented by neural oscillations. By using an Embedded Hidden Markov Model, we constructed a state space for resting state recordings consisting of brain states with different spatiotemporal patterns.
Article
Clinical Neurology
Stefan Rampp, Karl Rossler, Hajo Hamer, Margit Illek, Michael Buchfelder, Arnd Doerfler, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Konrad Koelble, Jose Eduardo Peixoto-Santos, Ingmar Blumcke, Roland Coras
Summary: This study demonstrated correlations between dysmorphic neurons and neurophysiological markers, identifying their role in seizure onset, fast gamma activity, and ripples, providing a new tool for localizing epileptic activity in the human brain.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Hsin-Yi Kao, Shuntong Hu, Temenuzhka Mihaylova, Julie Ziobro, EunSeon Ahn, Carli Fine, David Brang, Brendon O. Watson, Yu Wang
Summary: This study used continuous video-electroencephalography monitoring to detect early interictal and ictal events in a CRISPR-in utero electroporation FCDII rat model that shares genetic, pathological, and electroclinical characteristics with humans. The study found that epileptiform discharges emerged during the third postnatal week, with the first seizure occurring as early as the fourth postnatal week, and that both interictal and ictal discharges were localized within the dysplastic cortex.
Article
Clinical Neurology
G. Nithin, P. S. Sathidevi, P. M. Ameer
Summary: A graph energy based centrality approach was proposed for localizing the epileptogenic zone, showing that simple graph energy based centrality outperforms other methods in accuracy and f-score.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Clinical Neurology
Yujiang Wang, Gabrielle M. Schroeder, Jonathan J. Horsley, Mariella Panagiotopoulou, Fahmida A. Chowdhury, Beate Diehl, John S. Duncan, Andrew W. McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor
Summary: Comparing patient data to a normative map has shown promise in identifying abnormalities on interictal intracranial electroencephalogram (iEEG) for localization of epileptogenic tissue and outcome prediction. However, the temporal stability of these findings has not been established.
Article
Neurosciences
Francoise Lecaignard, Olivier Bertrand, Anne Caclin, Jeremie Mattout
Summary: This study transforms the question of the complementarity of EEG and MEG for source reconstruction from a general theoretical issue to a practical empirical one, focusing on evaluating multimodal data fusion on real data. The proposed approach utilizes Parametric Empirical Bayes' flexibility for EEG-MEG data fusion and formal hypothesis testing, demonstrating the advantages of multimodal inference, the greater spatial sensitivity of MEG compared to EEG, and the ability of EEG to reconstruct temporal lobe activity on its own.
Article
Clinical Neurology
Julie Bourgeois-Vionnet, Julien Jung, Romain Bouet, Mathilde Leclercq, Helene Catenoix, Laurent Bezin, Philippe Ryvlin, Sylvain Rheims
Summary: The study found that coffee consumption may be a protective factor for seizure-related respiratory dysfunction, with a dose-dependent effect.
Article
Neurosciences
Perrine Ruby, Mickael Eskinazi, Romain Bouet, Sylvain Rheims, Laure Peter-Derex
Summary: Sleep is interrupted by transient increases in vigilance levels called arousals or awakenings, which can affect cognitive functions. This study investigated brain activity in memory-related areas during short arousing reactions, finding that the hippocampus and frontal cortex have different patterns of activity during arousal/awakening, influenced by sleep stage. This suggests that the duration and intensity of these transitions may play a role in memory processes during sleep.
HUMAN BRAIN MAPPING
(2021)
Article
Behavioral Sciences
Diego Mac-Auliffe, Benoit Chatard, Mathilde Petton, Anne-Claire Croize, Florian Sipp, Benjamin Bontemps, Adrien Gannerie, Olivier Bertrand, Sylvain Rheims, Philippe Kahane, Jean-Philippe Lachaux
Summary: Dual-tasking is common nowadays, with evidence showing a performance cost due to interference. Neuroimaging studies suggest that neural interference in key regions may explain this dual-task cost. However, participants can adapt strategies flexibly to reduce reliance on executive control networks and minimize interference.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Bia Lima Ramalho, Julien Moly, Estelle Raffin, Romain Bouet, Sylvain Harquel, Alessandro Farne, Karen T. Reilly
Summary: This study investigated sensorimotor interactions between the face and hand using an afferent inhibition transcranial magnetic stimulation protocol. The results showed that facial stimulation can inhibit hand muscle motor responses, providing the first evidence for face-to-hand afferent inhibition.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Francoise Lecaignard, Olivier Bertrand, Anne Caclin, Jeremie Mattout
Summary: Predictive coding theory has a profound influence on brain functions and poses a fundamental paradox. Brain responses reflect precision-weighted prediction error, and it is necessary to differentiate the contributions of precision and prediction error in electrophysiology. By combining EEG and MEG, our study reveals adaptive learning of surprise in the brain and precision encoding through specific connections, which has important implications for applications in psychiatry.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Corentin Dauleac, Sebastien Boulogne, Cedric Y. Barrey, Jacques Guyotat, Emmanuel Jouanneau, Patrick Mertens, Moncef Berhouma, Julien Jung, Nathalie Andre-Obadia
Summary: This study assessed the accuracy of intraoperative neurophysiological monitoring (IONM) in predicting postoperative neurological outcomes in spinal cord surgery and identified factors associated with a higher risk of clinical worsening. The results showed that multimodal IONM significantly predicted postoperative deficits, and attention should be given to patients with preoperative electrophysiological abnormalities, large tumor volume, and intramedullary tumor location.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Instruments & Instrumentation
R. Bouet, J. Busto, V Cecchini, C. Cerna, A. Dastgheibi-Fard, F. Druillole, C. Jollet, P. Hellmuth, I Katsioulas, P. Knights, I Giomataris, M. Gros, P. Lautridou, A. Meregaglia, X. F. Navick, T. Neep, K. Nikolopoulos, F. Perrot, F. Piquemal, M. Roche, B. Thomas, R. Ward, M. Zampaolo
Summary: The possible use of a Spherical Proportional Counter for the search of neutrinoless double beta decay is investigated in the R2D2 R&D project. Tests were carried out using pure argon and a silicon photomultiplier to improve detector performance. The measured drift time and the light signal emitted during the avalanche development were found to be in agreement with simulations and could be used for event characterization.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Clinical Neurology
Andrew Neal, Romain Bouet, Stanislas Lagarde, Karine Ostrowsky-Coste, Louis Maillard, Philippe Kahane, Renaud Touraine, Helene Catenoix, Alexandra Montavont, Jean Isnard, Alexis Arzimanoglou, Marc Hermier, Marc Guenot, Fabrice Bartolomei, Sylvain Rheims, Julien Jung
Summary: This study investigates the interictal functional connectivity in patients with tuberous sclerosis complex (TSC) using stereo-electroencephalography (SEEG), and finds increased cortical synchrony among both tuber and nontuber networks in patients with epileptic spasms (ES), which is independent of both epileptogenic zone organization and tuber epileptogenicity.
Article
Neurosciences
Julien Jung, Romain Bouet, Helene Catenoix, Alexandra Montavont, Jean Isnard, Sebastien Boulogne, Marc Guenot, Philippe Ryvlin, Sylvain Rheims
Summary: PIH occurrence during temporal lobe seizures may be related to the activation of a widespread network of cortical structures, with the amygdala and anterior insula playing a key role.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Florent Cluse, Antoine Pegat, Thomas Ritzenthaler, Florent Gobert, Julien Jung
Summary: We present a case of a 19-year-old patient with acute-onset non-traumatic coma. The MRI was normal, but neurophysiological examinations indicated brainstem dysfunction. The patient was diagnosed with Bickerstaff's brainstem encephalitis (BBE) based on positive serum antibodies. The patient had favorable clinical and functional outcomes after treatment.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Respiratory System
Carolina Ciumas, Mayara Bolay, Romain Bouet, Sylvain Rheims, Danielle Ibarrola, Johnson P. Hampson, Samden D. Lhatoo, Philippe Ryvlin
Summary: Using fMRI, a study found that voluntary breath-holding can trigger neural responses in the respiratory centers and control centers in the brainstem. This method may serve as a biomarker for investigating disorders of central control of breathing in individual patients. Group analysis showed activation of most respiratory centers during breath-holding, with a significant relationship to the drop in SpO(2). Individual analysis revealed activations in cortical/subcortical and brainstem structures related to respiratory control in 19 out of 21 subjects.
Article
Psychology, Educational
Roxane S. Hoyer, Hesham Elshafei, Julie Hemmerlin, Romain Bouet, Aurelie Bidet-Caulet
Summary: Distractibility decreases as children grow older, with different developmental trajectories of distractibility components observed in different age groups. In young children, increased distractibility is mainly due to reduced sustained attention capacities, while in teenagers, it is primarily caused by decreased motor control and increased impulsivity.
