Article
Acoustics
K. Krajden Haratz, R. Birnbaum, D. Kidron, J. Har-Toov, Y. Salemnick, M. Brusilov, G. Malinger
Summary: This retrospective study aimed to identify neurosonographic findings that can diagnose or highly suggest the presence of malformations of cortical development before 24 weeks of gestation. The study cohort included 20 fetuses, with a mean gestational age at diagnosis of 18.7 weeks. Familiarity with fetal brain anatomy and its early sonographic landmarks allowed for early diagnosis of these malformations.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nils-Anders Labba, Hallvard Austin Waehler, Nora Houdaifi, Denis Zosen, Fred Haugen, Ragnhild Elisabeth Paulsen, Mussie Ghezu Hadera, Ragnhild Eskeland
Summary: The study revealed that APAP has negative effects on cell viability, migration, neuritogenesis, and neurodevelopment, resulting in reduced neurite arborization, decreased levels of cytoskeletal protein 132-spectrin, and disrupted integrity of cytoskeletal protein 133-tubulin.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Clinical Neurology
Katja Kobow, Stephanie Baulac, Andreas von Deimling, Jeong Ho Lee
Summary: Structural brain lesions are common causes of drug-resistant focal epilepsy, and epilepsy surgery can provide a curative treatment option. Pre-surgical diagnostic tools such as MRI and intracerebral EEG have limited specificity and accuracy in diagnosing lesion types. Neuropathological diagnosis remains the gold standard for disease classification but is complex with high inter-observer variability.
Article
Neurosciences
Minyoung Lee, Eun-Jin Kim, Min-Jee Kim, Mi-Sun Yum, Jeonghun Yeom, Kyunggon Kim
Summary: This study explores a treatment strategy for intractable epilepsy caused by malformation of cortical development (MCD) using an infant rat model. The results show significant downregulation of the synaptogenesis signaling pathway in the cortex of MCD rats. Pre-treatment with recombinant human insulin-growth factor-1 (rhIGF-1) delays the onset and reduces the number of spasms induced by N-methyl-d-aspartate (NMDA). Additionally, rhIGF1 pre-treatment leads to changes in cortical levels of glutathione (GSH), phosphocreatine (PCr), and total creatine (tCr), and upregulates the expression of cortical synaptic proteins.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Agronomy
Dandan Qin, Gang Liu, Rui Liu, Chunchao Wang, Fuchao Xu, Qing Xu, Yu Ling, Guoqing Dong, Yanchun Peng, Shuangtao Ge, Ganggang Guo, Jing Dong, Chengdao Li
Summary: This study identifies HvTUB8 as a candidate gene for barley spike and leaf development. The mutant phenotype of round lateral spikelet and dark green leaves is caused by changes in cell arrangement in the glume and enlarged chloroplasts. RNA-Seq analysis suggests that HvTUB8 may control spike morphogenesis through ethylene homeostasis and signaling, and regulate leaf color through chlorophyll metabolism. These findings provide new insights into the mechanisms of barley development.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Multidisciplinary Sciences
Gaotian Zhang, Nicole M. Roberto, Daehan Lee, Steffen R. Hahnel, Erik C. Andersen
Summary: This study investigates the association between genetic variation and gene expression variation in C. elegans, linking gene expression to organismal trait differences. The authors identify regulatory loci underlying gene expression variation and demonstrate how this variation could impact complex traits.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yingying Zhang, Zhilai Hong, Liang Zhou, Zhenkun Zhang, Ting Tang, Erpeng Guo, Jie Zheng, Ciji Wang, Lei Dai, Tong Si, Huan Wang
Summary: In this study, the discovery and biosynthesis of a group of III class lantibiotics named amylopeptins from the gut microbiota of Sprague-Dawley rats are reported. Its narrow antimicrobial spectrum sets it apart from known III class lantipeptides. The use of S8 family proteases in the biosynthesis of amylopeptins is highlighted as a novel finding.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Michael J. Bradshaw, Holly P. Bartholomew, Dylan Hendricks, Autumn Maust, Wayne M. Jurick
Summary: Through a meta-analysis of postharvest fungal pathogens, it was found that fungicide resistance is associated with specific mutations. The data show that fungicide-resistant beta-tubulin genotypes have been declining since 2005-2009, reflecting a decrease in FRAC-1 fungicide resistance in fungal populations.
Article
Biochemistry & Molecular Biology
Feifei Xu, Min Jia, Xin Li, Yu Tang, Keni Jiang, Jinsong Bao, Yangnan Gu
Summary: This study reveals the crucial role of XPO4 in plant immune responses, and its functional interplay with TPL and TPR in modulating the nuclear environment during CPR5-dependent immune induction, highlighting its significance in plant defense against pathogens.
Article
Plant Sciences
Heyang Shang, Linqi Fang, Lifang Qin, Hongtao Jiang, Zhenzhen Duan, Hai Zhang, Zongtao Yang, Guangyuan Cheng, Yixue Bao, Jingsheng Xu, Wei Yao, Muqing Zhang
Summary: This study identified the class III peroxidase (PRX) gene family in sugarcane using bioinformatics methods and real-time fluorescence quantitative PCR. Results showed that 82 PRX proteins were characterized as members of the class III PRX gene family in R570 STP. Phylogenetic analysis revealed that ShPRX family genes were divided into six groups. The study also found that PRX genes in sugarcane exhibited differential expression in response to SCMV, Cd, and salt stresses.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Xiaowan Hou, Zhiwei Lu, Keqian Hong, Kanghua Song, Hui Gu, Wei Hu, Quansheng Yao
Summary: Excessive production of ROS can be toxic to organisms, but the PRXs class of peroxidases in plants play a crucial role in maintaining ROS homeostasis. In this study, pineapples were soaked in ascorbic acid to reduce ROS and PPO activity, which successfully restrained the spread of internal browning (IB). With the identification of 78 pineapple PRX genes, research revealed their potential role in negatively regulating IB occurrence. This research provides valuable insights for further understanding the molecular mechanisms of IB and developing IB-resistant pineapple varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Genetics & Heredity
Lingtong Cheng, Lanxin Ma, Lijun Meng, Haihong Shang, Peijian Cao, Jingjing Jin
Summary: This study conducted a comprehensive analysis of the peroxidase (POD) gene family in tobacco and identified 210 non-redundant members. These genes were unevenly distributed throughout the 24 tobacco chromosomes and clustered into six subgroups based on phylogenetic analysis. Gene structure and motif analyses revealed the structural and functional diversity among the subgroups. The study also suggested that the evolution of NtPOD genes is influenced by segmental duplication and purifying selection. The expression patterns of NtPODs in different tissues and under various stress treatments were investigated, showing tissue-specific expression patterns and potential involvement in biotic and abiotic responses. qRT-PCR analyses and fluorescence assays confirmed the expression patterns and plasma membrane localization of NtPOD genes. Overall, these findings provide valuable insights into the evolution and function of the tobacco POD gene family.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Shuai Han, Xin Guo, Xiaogang Wang, Huijun Lin, Yiqi Yu, Jing Shu, Minyue Dong, Liwei Yang
Summary: Lymphatic malformation-6 (LMPHM6) is a rare form of lymphatic malformation that can cause widespread lymphedema. We identified a rare missense mutation in the PIEZO1 gene as a novel genetic cause of autosomal recessive LMPHM6.
FRONTIERS IN GENETICS
(2022)
Article
Microbiology
Hongyan Luo, Dekang Zhu, Mengru Li, Yunhan Tang, Wenyu Zhang, Haoju Wang, Pei Li
Summary: Whole-genome sequencing of Riemerella anatipestifer isolate RCAD0122 identified a novel ESBL gene, bla(RAA-1), which encoded a class A extended-spectrum beta-lactamase with low sequence identity to known beta-lactamases. The purified RAA-1 showed ESBL-like hydrolysis activity, and the gene could be transferred to a homologous strain through natural transformation. However, epidemiological study revealed the gene is not currently prevalent.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Oncology
Maria Di Bartolomeo, Alessandra Raimondi, Fabiola Cecchi, Daniel V. T. Catenacci, Sarit Schwartz, Shankar Sellappan, Yuan Tian, Rosalba Miceli, Alessandro Pellegrinelli, Elisa Giommoni, Enrico Aitini, Francesca Spada, Gerardo Rosati, Alberto Marchet, Francesca Pucci, Alberto Zaniboni, Stefano Tamberi, Tiziana Pressiani, Gianni Sanna, Maurizio Cantore, Stefania Mosconi, Paola Bolzoni, Carmine Pinto, Lorenza Landi, Hector Jose Soto Parra, Luigi Cavanna, Salvatore Corallo, Antonia Martinetti, Todd A. Hembrough, Filippo Pietrantonio
Summary: The study suggests that TUBB3 may serve as a negative predictive biomarker for taxane-based therapy in gastric cancer, with no prognostic value. Patients with high TUBB3 expression had poorer survival outcomes when receiving docetaxel-based chemotherapy. Further research is needed to evaluate the role of TUBB3 in neoadjuvant therapy.