Article
Clinical Neurology
Amanda Almacellas Barbanoj, Robert T. Graham, Benito Maffei, Jenna C. Carpenter, Marco Leite, Justin Hoke, Felisia Hardjo, James Scott-Solache, Christos Chimonides, Stephanie Schorge, Dimitri M. Kullmann, Vincent Magloire, Gabriele Lignani
Summary: Focal cortical dysplasias are a common type of cortical development abnormality that often leads to cognitive and behavioral abnormalities as well as drug-resistant epilepsy. A gene therapy approach targeting the overexpression of the Kv1.1 potassium channel has shown promising results in reducing seizures in a mouse model of frontal lobe focal cortical dysplasia.
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Lorenzo Ricci, Eleonora Tamilia, Mattia Mercier, Chiara Pepi, Giusy Carfi-Pavia, Alessandro De Benedictis, Giovanni Assenza, Vincenzo Di Lazzaro, Federico Vigevano, Nicola Specchio, Luca de Palma
Summary: This study aimed to evaluate whether ictal phase-amplitude coupling (PAC) could be used as a preoperative biomarker for Focal Cortical Dysplasia (FCD) subtypes. It was found that the strength of ictal PAC was significantly higher in patients with FCD type II compared to type I, only on SOZ electrodes. Pre-ictal PAC on SOZ electrodes predicted FCD histopathology with a classification accuracy > 0.9.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Rupesh Kumar Chikara, Saeed Jahromi, Eleonora Tamilia, Joseph R. Madsen, Steve M. Stufflebeam, Phillip L. Pearl, Christos Papadelis
Summary: The study aims to evaluate the diagnostic accuracy of electromagnetic source imaging (EMSI) in localizing spikes and predicting surgical outcome in children with drug resistant epilepsy (DRE) due to focal cortical dysplasia (FCD). We analyzed MEG and HD-EEG data from 23 children and compared the localization accuracy and predictive performance of EMSI, ESI, and MSI. The results showed that EMSI had superior localization accuracy and predictive performance compared to individual modalities.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Behavioral Sciences
Yunling Wang, Chenmin He, Cong Chen, Zhongjin Wang, Wenjie Ming, Jingjing Qiu, Meiping Ying, Wei Chen, Bo Jin, Hong Li, Meiping Ding, Shuang Wang
Summary: The study found that focal cortical dysplasia (FCD) is a significantly independent risk factor associated with sleep-related epilepsy (SRE), with the highest incidence of SRE in the FCD group. A small lesion size of FCD further increased the risk of SRE.
EPILEPSY & BEHAVIOR
(2022)
Article
Clinical Neurology
Radek Janca, Petr Jezdik, Matyas Ebel, Adam Kalina, Martin Kudr, Alena Jahodova, David Krysl, Katerina Mackova, Barbora Straka, Petr Marusic, Pavel Krsek
Summary: This study demonstrates that electrophysiological patterns can accurately differentiate FCD types and help predict presurgical MRI findings, providing more precise surgical plans for patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Horst Urbach, Marcel Heers, Dirk-Matthias Altenmueller, Andreas Schulze-Bonhage, Anke Maren Staack, Thomas Bast, Marco Reisert, Ralf Schwarzwald, Christoph P. Kaller, Hans-Juergen Huppertz, Theo Demerath
Summary: Automated MRI postprocessing tool was evaluated for enhanced and rapid detection of focal cortical dysplasia (FCD). The results showed effective identification of FCD within a minute, with a need for careful comparison with conventional MRI images to reduce false positives.
Article
Clinical Neurology
Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Guttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefania Conde-Blanco, Jose Carlos Pariente, Saul Pascual-Diaz, Ignacio Delgado-Martinez, Carmen Perez-Enriquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Eugenia Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane G. Kloster, Giske Opheim, Leticia Ribeiro, Clarissa Yasuda, Camilla Rossi-Espagnet, Khalid Hamandi, Anna Tietze, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofia Gonzalez-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terence O'Brien, Jay Shetty, Graeme Jackson, John S. Duncan, Gavin P. Winston, Lars H. Pinborg, Fernando Cendes, Fabian J. Theis, Russell T. Shinohara, J. Helen Cross, Torsten Baldeweg, Sophie Adler, Konrad Wagstyl
Summary: One of the challenges in applying machine learning to diagnostic biomedical imaging is the interpretability of algorithms. This study developed an open-source and interpretable machine-learning algorithm to automatically identify FCDs from structural MRI data, improving the confidence of physicians in identifying subtle MRI lesions in individuals with epilepsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Jie Yu, Ming Zhou, Jian Li, Tingting Long, Yulai Li, Li Feng, Dengming Chen, Zhiquan Yang, Yiyun Huang, Shuo Hu
Summary: In this study, the SV2A abnormalities in patients with FCD II were evaluated using F-18-SynVesT-1 PET and compared with F-18-FDG PET. The results showed that F-18-SynVesT-1 PET had a higher accuracy for the localization of FCD II lesions than MRI and a more restricted pattern of abnormality than F-18-FDG PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Shaoping Zhong, Zhihao Zhao, Wanjing Xie, Yiying Cai, Yiying Zhang, Jing Ding, Xin Wang
Summary: This study confirmed a profound disturbance in GABAergic interneurons and synaptic transmission in patients with type II FCD, which is related to the activation status of mTOR. Postnatal mTOR inhibition can partially rescue this disturbance. The results also suggest that postsynaptic mechanisms independent of interneuron reduction or altered expression of GABA synapse genes might be responsible for the impaired GABAergic neurotransmission in type II FCD.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Mengyi Guo, Jing Zhang, Jing Wang, Xiongfei Wang, Qing Gao, Chongyang Tang, Jiahui Deng, Zhonghua Xiong, Xiangru Kong, Yuguang Guan, Jian Zhou, Detlev Boison, Guoming Luan, Tianfu Li
Summary: In this study, the adenosine signaling in FCD type I and type II patients was analyzed, revealing upregulation of adenosine-metabolizing enzymes ADK and ADA, as well as adenosine-producing enzyme CD73 in BCs. Moreover, an increase in A(2A)R density, a decrease in GLT-1 levels, and an increase in mTOR levels were observed in FCD specimens. These findings suggest that dysregulation of the adenosine system is a common pathological feature of both FCD type I and type II, and may serve as a therapeutic target for epilepsy associated with FCD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Ariane Lewis, Steven Galetta
Summary: In their research article, Chassoux et al. conducted a retrospective review on 60 patients with focal cortical dysplasia type 2 (FCD2) in the central region who underwent surgical resection. They found that 88% of patients achieved seizure freedom after surgery, and although 87% experienced early transitory postoperative deficits, 40% of them fully recovered. It was also observed that patients with FCD2 can have preoperative and postoperative neurologic deficits, and some patients showed improvement after surgery.
Article
Pharmacology & Pharmacy
Jinha Park, Se Hee Kim, Jongsung Hahn, Hoon-Chul Kang, Sang-Guk Lee, Heung Dong Kim, Min Jung Chang
Summary: Based on a population pharmacokinetic model of everolimus in FCD patients, this study recommends an optimal dose regimen for FCD patients. The recommended dose ranges from 7 mg/m2 or higher for patients with BSA 0.5 m2, to 6 mg/m2 or higher for patients with BSA 0.7 m2. A dose of 4.5 mg/m2 is sufficient for patients with BSA higher than 1.5 m2 to achieve the target trough range of 5-15 ng/mL.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Daisuke Hasegawa, Rikako Asada, Yuji Hamamoto, Yoshihiko Yu, Takayuki Kuwabara, Shunta Mizoguchi, James K. Chambers, Kazuyuki Uchida
Summary: Epilepsy surgery is a common therapeutic option for drug-resistant epilepsy in humans, but very few reports exist in veterinary medicine. This case study showcases successful intracranial epilepsy surgery in a cat, with presurgical evaluations using advanced imaging techniques to identify the epileptogenic zone and ultimately reducing seizure frequency.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pediatrics
Michael Wagner, Tobias Werther, Ewald Unger, Gregor Kasprian, Gregor Dovjak, Christian Dorfer, Hannah Schned, Philipp Steinbauer, Katharina Goeral, Monika Olischar, Karl Roessler, Angelika Berger, Gunpreet Oberoi
Summary: This pilot study developed realistic neonatal brain models, including the ventricular system, using multimodality imaging. MRI and 3D ultrasound were found to be comparable in deriving anatomical information of the neonatal brain. Further research on dimensional correlations is needed to establish 3D ultrasound as a standard for producing high-quality 3D printed models.
PEDIATRIC RESEARCH
(2022)
Article
Otorhinolaryngology
Yavor Bozhkov, Julia Shawarba, Julian Feulner, Fabian Winter, Stefan Rampp, Ullrich Hoppe, Arnd Doerfler, Heinrich Iro, Michael Buchfelder, Karl Roessler
Summary: Surgery for small vestibular schwannomas can achieve excellent hearing preservation. Different grading systems have a significant impact on and correlate with postoperative hearing preservation. Tumor size appears to be more important than anatomical relationships.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, General & Internal
Fabian Winter, Celia M. Markert, Maximilian Krawagna, Michael Buchfelder, Karl Roessler
Summary: This study compared radiological parameters and clinical outcomes between patients younger than 65 years and those over 65 years of age with cerebral aneurysms. It found that the Glasgow outcome scale was significantly lower in the older group after clipping of ruptured aneurysms, but not significantly different after clipping of unruptured aneurysms.
WIENER KLINISCHE WOCHENSCHRIFT
(2022)
Article
Clinical Neurology
Samir Jabari, Katja Kobow, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Tilman Polster, Christian G. Bien, Thilo Kalbhenn, Matthias Simon, Hajo Hamer, Karl Roessler, Martha Feucht, Angelika Muehlebner, Imad Najm, Jose Eduardo Peixoto-Santos, Antonio Gil-Nagel, Rafael Toledano Delgado, Angel Aledo-Serrano, Yanghao Hou, Roland Coras, Andreas von Deimling, Ingmar Bluemcke
Summary: This study conducted a multi-center analysis of brain specimens using DNA methylation to investigate the classification of malformations of cortical development (MCD), which are frequently associated with epilepsy. The deep learning model showed the highest level of accuracy, providing new insights for the diagnosis and classification of MCD.
ACTA NEUROPATHOLOGICA
(2022)
Article
Oncology
Gilbert Hangel, Philipp Lazen, Sukrit Sharma, Barbara Hristoska, Cornelius Cadrien, Julia Furtner, Ivo Rausch, Alexandra Lipka, Eva Niess, Lukas Hingerl, Stanislav Motyka, Stephan Gruber, Bernhard Strasser, Barbara Kiesel, Matthias Preusser, Thomas Roetzer-Pejrimovsky, Adelheid Woehrer, Wolfgang Bogner, Georg Widhalm, Karl Roessler, Tatjana Traub-Weidinger, Siegfried Trattnig
Summary: This study compared the application of 7T magnetic resonance spectroscopic imaging (MRSI) with amino acid positron emission tomography (PET) in glioma patients. The results showed that the ratios of glutamine and glycine in MRSI had better correspondence to PET signals, while the commonly used choline did not.
Editorial Material
Behavioral Sciences
Rafael Naime Ruggiero, Jose Eduardo Peixoto-Santos, Lezio Soares Bueno-Junior, Kette D. Valente, Joao Pereira Leite
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: This study describes the clinical, genetic, neuroimaging, EEG, and histopathologic findings in patients with refractory epilepsy and brain somatic SLC35A2 gene variants. It also assesses possible predictors of postoperative seizure and cognitive outcomes.
Article
Clinical Neurology
Ann-Kathrin Bruzsa, Katrin Walther, Burkhard S. Kasper, Stefanie Gollwitzer, Hajo Hamer, Michael Schwarz
Summary: This study analyzes the prognostic value of intracarotid amobarbital procedure (Wada test) in addition to specific neuropsychological and clinical variables for postoperative memory changes. The results show that the Wada test is still a useful diagnostic tool for a subgroup of patients with clinical indicators.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Katrin Walther, Peter Kriwy, Jenny Stritzelberger, Wolfgang Graf, Stefanie Gollwitzer, Johannes D. Lang, Caroline Reindl, Stefan Schwab, Tamara M. Welte, Hajo M. Hamer
Summary: The aim of this study was to examine whether epilepsy is a barrier to desired friendship. Participants included persons with epilepsy, their relatives, and lay persons. The results showed that individuals without direct contact with persons with epilepsy were less interested in forming friendships, particularly with those who had severe epilepsy.
Article
Clinical Neurology
Matthias Tomschik, Dominik Wiedner, Johannes Herta, Jonathan Wais, Fabian Winter, Karl Roessler, Christian Dorfer
Summary: The use of non-steroidal anti-inflammatory drugs (NSAIDs) does not increase the recurrence rates of chronic subdural hematoma (cSDH), while male sex is identified as a risk factor for cSDH recurrence.
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marisol Soula, Anna Maslarova, Ryan E. Harvey, Manuel Valero, Sebastian Brandner, Hajo Hamer, Antonio Fernandez-Ruiz, Gyorgy Buzsaki
Summary: Interictal epileptiform discharges (IEDs) are common electrophysiological events observed in epilepsy and other neurological diseases. This study characterizes and compares IEDs in human epilepsy patients and AD transgenic mice, finding similar features and effects on the hippocampal circuit. The findings suggest that IEDs may play a role in cognitive deficits and memory interference.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Olga Ciobanu-Caraus, Thomas Czech, Andreas Peyrl, Christine Haberler, Gregor Kasprian, Julia Furtner, Marcel Kool, Martin Sill, Josa M. Frischer, Anna Cho, Irene Slavc, Karl Roessler, Johannes Gojo, Christian Dorfer
Summary: This study investigated the correlation between intraoperative observation of the site of origin and molecular subtypes of medulloblastoma (MB). The results showed that intraoperative observation had limited predictive value for determining the molecular subtype. Therefore, maximal safe resection should remain the aim of surgery.
Article
Medicine, General & Internal
Farjad Khalaveh, Mario Mischkulnig, Vitalij Zeiser, Matthias G. Vossen, Andrea Reinprecht, Christian Dorfer, Karl Roessler, Johannes Herta
Summary: This study demonstrates that CSF parameters collected from the EVD collection bag can be reliably assessed, reducing manipulation at the proximal port and minimizing the risk of infection.
Article
Clinical Neurology
Carmen Barba, Ingmar Blumcke, Melodie R. Winawer, Till Hartlieb, Hoon-Chul Kang, Laura Grisotto, Mathilde Chipaux, Christian G. Bien, Barbora Hermanovska, Brenda E. Porter, Hart G. W. Lidov, Valentina Cetica, Friedrich G. Woermann, Javier A. Lopez-Rivera, Peter D. Canoll, Irina Mader, Ludovico D'Incerti, Sara Baldassari, Edward Yang, Ahmed Gaballa, Hannes Vogel, Barbora Straka, Letizia Macconi, Tilman Polster, Gerald A. Grant, Lenka Krskova, Hui Jin Shin, Ara Ko, Peter B. Crino, Pavel Krsek, Jeong Ho Lee, Dennis Lal, Stephanie Baulac, Annapurna Poduri, Renzo Guerrini
Summary: Brain somatic SLC35A2 gene variants are associated with two main clinical phenotypes, early epileptic encephalopathy (EE) and drug-resistant focal epilepsy (DR-FE). Most patients showed unchanged cognitive performances after surgery, with better postoperative seizure control outcomes seen in cases where postoperative EEG was normal or improved.
Article
Clinical Neurology
Dorian Hirschmann, Thomas Czech, Karl Roessler, Paul Krachsberger, Shivam Paliwal, Olga Ciobanu-Caraus, Anna Cho, Andreas Peyrl, Martha Feucht, Josa Maria Frischer, Christian Dorfer
Summary: The objective of this study is to provide a treatment algorithm for pediatric patients with intracranial cavernous malformations (CMs) based on the authors' experience. The study retrospectively evaluated pediatric patients under the age of 18 who were treated either surgically or conservatively between 1982 and 2019. The results showed that surgical treatment was associated with larger lesions and higher seizure prevalence in patients with lobar CMs, while a more aggressive approach was associated with higher modified Rankin scale scores in patients with deep CMs. The study suggests a treatment algorithm based on lesion location and size, symptom burden, epilepsy workup, and clinical course.
NEUROSURGICAL REVIEW
(2022)
