Extracellular Vesicles at CNS barriers: Mode of action

CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

(2022) Michael Mazzucco et al.   Fluids and Barriers of the CNS

The power of imaging to understand extracellular vesicle biology in vivo

(2021) Frederik J. Verweij et al.   NATURE METHODS

Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

(2021) Charysse Vandendriessche et al.   Acta Neuropathologica Communications

Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation

(2021) David Roig-Carles et al.   Pharmaceutics

Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C

(2021) Lien Van Hoecke et al.   Frontiers in Cellular Neuroscience

Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

(2021) Marie J. Pauwels et al.   Biomedicines

Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo

(2020) Ivan-Maximiliano Kur et al.   PLOS BIOLOGY

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

(2020) Julien Saint-Pol et al.   Cells

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

(2020) William A. Banks et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro

(2020) Ulrike Erb et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal regulation of the blood–brain barrier and neurovascular coupling

(2020) Luke Kaplan et al.   NATURE REVIEWS NEUROSCIENCE

Heparan sulfate proteoglycan‐mediated dynamin‐dependent transport of neural stem cell exosomes in an in vitro blood–brain barrier model

(2020) Bhagyashree S. Joshi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neural Progenitor Cell-Derived Extracellular Vesicles Enhance Blood-Brain Barrier Integrity by NF-κB (Nuclear Factor-κB) Dependent Regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in Stroke Mice

(2020) Lin Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

(2020) Hossam Kadry et al.   Fluids and Barriers of the CNS

Leukemia-derived exosomes and cytokines pave the way for entry into the brain

(2019) Ichiko Kinjyo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain

(2019) Tjasa Lepko et al.   EMBO JOURNAL

Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress?

(2019) J. Winny Yun et al.   Frontiers in Immunology

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

(2019) Anjana Ajikumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles and Neurodegenerative Diseases

(2019) Andrew F. Hill   JOURNAL OF NEUROSCIENCE

Systemic Immune Response to Traumatic CNS Injuries—Are Extracellular Vesicles the Missing Link?

(2019) Abi G. Yates et al.   Frontiers in Immunology

Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock

(2019) Aaron M. Williams et al.   Journal of Trauma and Acute Care Surgery

Endothelial colony-forming cell-derived exosomes restore blood-brain barrier continuity in mice subjected to traumatic brain injury

(2018) Weiwei Gao et al.   EXPERIMENTAL NEUROLOGY

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

(2018) Mengke Qu et al.   JOURNAL OF CONTROLLED RELEASE

Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

(2018) Hiroki Kuroda et al.   MOLECULAR PHARMACEUTICS

Pericytes secrete pro-regenerative molecules in response to platelet-derived growth factor-BB

(2017) Abderahim Gaceb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

(2017) Junichi Matsumoto et al.   Acta Neuropathologica Communications

Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation

(2017) Yvonne Couch et al.   Scientific Reports

Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway

(2017) Pranjali Dalvi et al.   Scientific Reports

Extracellular vesicles: interneural shuttles of complex messages

(2016) Eva-Maria Krämer-Albers et al.   CURRENT OPINION IN NEUROBIOLOGY

Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles

(2016) Sriram Balusu et al.   EMBO Molecular Medicine

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury

(2016) Allison M. Andrews et al.   Frontiers in Cellular Neuroscience

DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients

(2016) Noemí García-Romero et al.   Oncotarget

Driving the Hypoxia-Inducible Pathway in Human Pericytes Promotes Vascular Density in an Exosome-Dependent Manner

(2015) Jamie N. Mayo et al.   MICROCIRCULATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium

(2009) Dorothée Faille et al.   FASEB JOURNAL

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE