Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood–Spinal Cord Barrier After Spinal Cord Injury in Mice

(2019) Xiaochen Yuan et al.   Frontiers in Neuroscience

Acetylcholinesterase is not a generic marker of extracellular vesicles

(2019) Zhaohao Liao et al.   Journal of Extracellular Vesicles

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

(2018) Hiroki Kuroda et al.   MOLECULAR PHARMACEUTICS

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease

(2017) Roger J. Mullins et al.   HUMAN BRAIN MAPPING

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology

(2017) Ibolya E. András et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

A Perspective on Extracellular Vesicles Proteomics

(2017) Livia Rosa-Fernandes et al.   Frontiers in Chemistry

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

(2017) Junichi Matsumoto et al.   Acta Neuropathologica Communications

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Exosomes as Tools to Suppress Primary Brain Tumor

(2016) Mark Katakowski et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles

(2016) Sriram Balusu et al.   EMBO Molecular Medicine

Proteomics and the blood–brain barrier: how recent findings help drug development

(2016) Yannis Karamanos et al.   Expert Review of Proteomics

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Into rather unexplored terrain-transcellular transport across the blood-brain barrier

(2016) Marijke De Bock et al.   GLIA

The Translational Significance of the Neurovascular Unit

(2016) Heather L. McConnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration

(2016) Elodie Vandenhaute et al.   LABORATORY INVESTIGATION

Designer exosomes as next-generation cancer immunotherapy

(2016) Brandon M. Bell et al.   Nanomedicine-Nanotechnology Biology and Medicine

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

(2016) Akvilė Jarmalavičiūtė et al.   PHARMACOLOGICAL RESEARCH

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients

(2016) Noemí García-Romero et al.   Oncotarget

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

(2016) Erin L. Abner et al.   Annals of Clinical and Translational Neurology

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

(2015) Hugo Peluffo et al.   BIOTECHNOLOGY ADVANCES

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects

(2015) Reiner F. Haseloff et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

The neurovascular unit - concept review

(2014) V. Muoio et al.   Acta Physiologica

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies

(2014) Anita Geevarghese et al.   Translational Research

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

(2013) Julien Saint-Pol et al.   BRAIN RESEARCH

Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier

(2013) Fabien Gosselet et al.   Current Alzheimer Research

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

(2012) Hina Kalra et al.   PLOS BIOLOGY

Identification of Distinct Populations of Prostasomes That Differentially Express Prostate Stem Cell Antigen, Annexin A1, and GLIPR2 in Humans1

(2011) Marian Aalberts et al.   BIOLOGY OF REPRODUCTION

Intranasal Exosomes for Treatment of Neuroinflammation?: Prospects and Limitations

(2011) Samira Lakhal et al.   MOLECULAR THERAPY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE