Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells
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Title
Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells
Authors
Keywords
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Journal
CELL
Volume 185, Issue 14, Pages 2542-2558.e18
Publisher
Elsevier BV
Online
2022-06-16
DOI
10.1016/j.cell.2022.05.018
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Note: Only part of the references are listed.- Comprehensive analysis of single cell ATAC-seq data with SnapATAC
- (2021) Rongxin Fang et al. Nature Communications
- GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility
- (2021) Daniel Eriksson et al. Nature Communications
- Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
- (2021) Jhoanne L. Bautista et al. Nature Communications
- Modular, efficient and constant-memory single-cell RNA-seq preprocessing
- (2021) Páll Melsted et al. NATURE BIOTECHNOLOGY
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*
- (2021) Caroline Kaiser et al. IMMUNOLOGICAL REVIEWS
- Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers
- (2021) Kushagra Bansal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A cell atlas of human thymic development defines T cell repertoire formation
- (2020) Jong-Eun Park et al. SCIENCE
- A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
- (2020) Michal Slyper et al. NATURE MEDICINE
- Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
- (2020) Beth Lucas et al. Nature Communications
- Generalizing RNA velocity to transient cell states through dynamical modeling
- (2020) Volker Bergen et al. NATURE BIOTECHNOLOGY
- Ageing compromises mouse thymus function and remodels epithelial cell differentiation
- (2020) Jeanette Baran-Gale et al. eLife
- Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells
- (2020) Kristen L Wells et al. eLife
- Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice
- (2019) Shunsuke Kimura et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A reinforcing HNF4–SMAD4 feed-forward module stabilizes enterocyte identity
- (2019) Lei Chen et al. NATURE GENETICS
- Peak calling by Sparse Enrichment Analysis for CUT&RUN chromatin profiling
- (2019) Michael P. Meers et al. Epigenetics & Chromatin
- CUT&Tag for efficient epigenomic profiling of small samples and single cells
- (2019) Hatice S. Kaya-Okur et al. Nature Communications
- Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells
- (2019) Fatima Dhalla et al. EMBO JOURNAL
- Rapid chromatin repression by Aire provides precise control of immune tolerance
- (2018) Andrew S. Koh et al. NATURE IMMUNOLOGY
- Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
- (2018) Chamutal Bornstein et al. NATURE
- Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
- (2018) Corey N. Miller et al. NATURE
- A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
- (2018) Daniel T. Montoro et al. NATURE
- Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
- (2018) Adam E. Handel et al. Frontiers in Immunology
- A single-cell survey of the small intestinal epithelium
- (2017) Adam L. Haber et al. NATURE
- chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
- (2017) Alicia N Schep et al. NATURE METHODS
- Fox transcription factors: from development to disease
- (2016) Maria L. Golson et al. DEVELOPMENT
- Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life
- (2016) Michael Cangkrama et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns
- (2016) Deepali Malhotra et al. NATURE IMMUNOLOGY
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
- (2016) Simon Joost et al. Cell Systems
- Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullary junction
- (2015) Lucas Onder et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases
- (2015) Bergithe E. Oftedal et al. IMMUNITY
- More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers
- (2015) Garry Dolton et al. IMMUNOLOGY
- Single-cell chromatin accessibility reveals principles of regulatory variation
- (2015) Jason D. Buenrostro et al. NATURE
- Aire controls gene expression in the thymic epithelium with ordered stochasticity
- (2015) Matthew Meredith et al. NATURE IMMUNOLOGY
- The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance
- (2015) Anna Chuprin et al. NATURE IMMUNOLOGY
- Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
- (2015) Philip Brennecke et al. NATURE IMMUNOLOGY
- Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells
- (2015) Hideyuki Yoshida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
- (2015) S. Yang et al. SCIENCE
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging
- (2014) Nicolas Renier et al. CELL
- Cholinergic epithelial cell with chemosensory traits in murine thymic medulla
- (2014) Alexandra Regina Panneck et al. CELL AND TISSUE RESEARCH
- Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
- (2014) Stephen N. Sansom et al. GENOME RESEARCH
- The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
- (2013) Yang Liao et al. NUCLEIC ACIDS RESEARCH
- Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
- (2013) S. Pinto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lineage Tracing and Cell Ablation Identify a Post-Aire-Expressing Thymic Epithelial Cell Population
- (2013) Todd C. Metzger et al. Cell Reports
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Spi-B is critical for plasmacytoid dendritic cell function and development
- (2012) I. Sasaki et al. BLOOD
- The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells
- (2012) Takashi Kanaya et al. NATURE IMMUNOLOGY
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population
- (2011) Chikashi Terao et al. HUMAN MOLECULAR GENETICS
- Integrative genomics viewer
- (2011) James T Robinson et al. NATURE BIOTECHNOLOGY
- Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
- (2011) M. Giraud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Aire's Partners in the Molecular Control of Immunological Tolerance
- (2010) Jakub Abramson et al. CELL
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
- (2010) Xiangdong Liu et al. NATURE GENETICS
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
- (2009) Mireia Guerau-de-Arellano et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- Tracking epitope-specific T cells
- (2009) James J Moon et al. Nature Protocols
- Sox8 is a critical regulator of adult Sertoli cell function and male fertility
- (2008) Moira K. O'Bryan et al. DEVELOPMENTAL BIOLOGY
- Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
- (2008) J. Villasenor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity
- (2008) A. S. Koh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
- (2008) J. Derbinski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
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