Fox transcription factors: from development to disease

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Cell fate control by pioneer transcription factors

(2016) Makiko Iwafuchi-Doi et al.   DEVELOPMENT

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

Forkhead box transcription factors in embryonic heart development and congenital heart disease

(2016) Hong Zhu   LIFE SCIENCES

The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation

(2016) Makiko Iwafuchi-Doi et al.   MOLECULAR CELL

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

FOXA2 attenuates the epithelial to mesenchymal transition by regulating the transcription of E-cadherin and ZEB2 in human breast cancer

(2015) Zhen Zhang et al.   CANCER LETTERS

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

(2015) Maria L. Golson et al.   DIABETES

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice

(2015) Jason M. Spaeth et al.   DIABETOLOGIA

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis

(2015) Carman Man-Chung Li et al.   GENES & DEVELOPMENT

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

(2015) X. Li et al.   Molecular Systems Biology

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

(2015) Rachel Kaletsky et al.   NATURE

Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4

(2015) H.- T. Hsu et al.   SCIENCE

Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer

(2015) Weikang Zhang et al.   OncoTargets and Therapy

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

(2015) Dominic Jones et al.   Oncotarget

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

(2015) Xin Xie et al.   PLoS Genetics

The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA

(2015) Ming Wang et al.   Oncotarget

FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition

(2014) Jian Wang et al.   CARCINOGENESIS

The Transcription Factor FOXA2 Suppresses Gastric Tumorigenesis In Vitro and In Vivo

(2014) Chang-Peng Zhu et al.   DIGESTIVE DISEASES AND SCIENCES

Caloric restriction and the aging process: a critique

(2014) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lifespan Modulation in Mice and the Confounding Effects of Genetic Background

(2014) Lorna Mulvey et al.   Journal of Genetics and Genomics

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

(2014) David J DeGraff et al.   LABORATORY INVESTIGATION

Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour

(2014) C Bacon et al.   MOLECULAR PSYCHIATRY

Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration

(2014) Alexandra B. Byrne et al.   NEURON

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

(2014) Michael V. Gormally et al.   Nature Communications

Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

(2014) Stanislav Nagy et al.   eLife

Combination of Oxidative Stress and FOXM1 Inhibitors Induces Apoptosis in Cancer Cells and Inhibits Xenograft Tumor Growth

(2013) Marianna Halasi et al.   AMERICAN JOURNAL OF PATHOLOGY

The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness

(2013) Diego Sisci et al.   CELL CYCLE

The Role of the FOXP Family of Transcription Factors in ASD

(2013) J. Michael Bowers et al.   DISEASE MARKERS

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes

(2013) J. M. Caravaca et al.   GENES & DEVELOPMENT

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

FOX(M1) News--It Is Cancer

(2013) M. Halasi et al.   MOLECULAR CANCER THERAPEUTICS

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

(2013) Christian G. Riedel et al.   NATURE CELL BIOLOGY

Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D

(2013) I-C Wang et al.   ONCOGENE

Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

(2013) Deborah A Sanders et al.   GENOME BIOLOGY

FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

(2012) Masaki Kobayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Foxa2 and H2A.Z Mediate Nucleosome Depletion during Embryonic Stem Cell Differentiation

(2012) Zhaoyu Li et al.   CELL

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

(2012) S. Li et al.   DEVELOPMENT

The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders

(2012) Claire Bacon et al.   HUMAN GENETICS

Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System

(2012) M. L. Toth et al.   JOURNAL OF NEUROSCIENCE

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

(2012) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage

(2012) Marianna Halasi et al.   PLoS One

FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway

(2012) Yusuke Imamura et al.   PLoS One

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

(2011) William R. Swindell   AGEING RESEARCH REVIEWS

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A complex regulatory network of transcription factors critical for ocular development and disease

(2011) Moulinath Acharya et al.   HUMAN MOLECULAR GENETICS

Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans

(2011) E. M. H. Tank et al.   JOURNAL OF NEUROSCIENCE

The nucleosome map of the mammalian liver

(2011) Zhaoyu Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of Foxm1 Transcription Factor in Cardiomyocytes Is Required for Myocardial Development

(2011) Craig Bolte et al.   PLoS One

Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro

(2010) Qi-fei Wu et al.   ACTA PHARMACOLOGICA SINICA

De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment

(2010) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

(2010) Yunneng Tang et al.   CELL RESEARCH

Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia

(2010) I-Ching Wang et al.   DEVELOPMENTAL BIOLOGY

A new target for proteasome inhibitors: FoxM1

(2010) Andrei L Gartel   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits

(2010) Denise Horn et al.   HUMAN MUTATION

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXA1 is a key determinant of estrogen receptor function and endocrine response

(2010) Antoni Hurtado et al.   NATURE GENETICS

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

(2010) D. R. Littler et al.   NUCLEIC ACIDS RESEARCH

Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age

(2010) Amanda L. Kauffman et al.   PLOS BIOLOGY

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Epigenetic mechanisms of regulation of Foxp3 expression

(2009) G. Lal et al.   BLOOD

Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus

(2009) Vladimir Ustiyan et al.   DEVELOPMENTAL BIOLOGY

Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and D-Cells in Mice

(2009) Diana Z. Ye et al.   GASTROENTEROLOGY

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

(2009) Yang Li et al.   HUMAN MOLECULAR GENETICS

Regulation of adaptive behaviour during fasting by hypothalamic Foxa2

(2009) Jose P. Silva et al.   NATURE

The evolution of Fox genes and their role in development and disease

(2009) Sridhar Hannenhalli et al.   NATURE REVIEWS GENETICS

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells

(2008) Maria van der Sluis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance

(2008) Hany Onsy Habashy et al.   EUROPEAN JOURNAL OF CANCER

Cooperative regulation in development by SMRT and FOXP1

(2008) K. Jepsen et al.   GENES & DEVELOPMENT

C. elegans dauer formation and the molecular basis of plasticity

(2008) N. Fielenbach et al.   GENES & DEVELOPMENT

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development

(2008) N. Gao et al.   GENES & DEVELOPMENT

Foxl1 is a marker of bipotential hepatic progenitor cells in mice

(2008) Sara D. Sackett et al.   HEPATOLOGY

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

Forkhead Box m1 transcription factor is required for perinatal lung function

(2008) T. V. Kalin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

(2007) Noritaka Yamaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS