Alternative NF-κB signaling regulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullary junction

Adult Thymus Contains FoxN1− Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages

(2014) Ahmet Ucar et al.   IMMUNITY

Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance

(2014) Miho Sekai et al.   IMMUNITY

The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells

(2014) N. Seach et al.   JOURNAL OF IMMUNOLOGY

Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion

(2014) F. Frommer et al.   JOURNAL OF IMMUNOLOGY

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus

(2014) Kahlia Wong et al.   Cell Reports

Generation of both cortical and Aire+medullary thymic epithelial compartments from CD205+progenitors

(2013) Song Baik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Serial progression of cortical and medullary thymic epithelial microenvironments

(2013) Nuno L. Alves et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

(2013) Qian Chai et al.   IMMUNITY

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymocyte Selection Regulates the Homeostasis of IL-7-Expressing Thymic Cortical Epithelial Cells In Vivo

(2013) A. R. Ribeiro et al.   JOURNAL OF IMMUNOLOGY

Aire-expressing thymic medullary epithelial cells originate from  5t-expressing progenitor cells

(2013) I. Ohigashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy

(2012) Veronika Nindl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

Lymphotoxin   Receptor Activation on Macrophages Induces Cross-Tolerance to TLR4 and TLR9 Ligands

(2012) N. Wimmer et al.   JOURNAL OF IMMUNOLOGY

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

(2012) Deepali Malhotra et al.   NATURE IMMUNOLOGY

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans

(2011) HuiJuan Lv et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel bacterial artificial chromosome-transgenic Podoplanin–Cre mouse targets lymphoid organ stromal cells in vivo

(2011) Lucas Onder   Frontiers in Immunology

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

Role of thymic cortex-specific self-peptides in positive selection of T cells

(2010) Yousuke Takahama et al.   SEMINARS IN IMMUNOLOGY

Spatial Mapping of Thymic Stromal Microenvironments Reveals Unique Features Influencing T Lymphoid Differentiation

(2009) Ann V. Griffith et al.   IMMUNITY

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Original Intrathymic Progenitor from Which T Cells Originate

(2009) J. C. Zuniga-Pflucker   JOURNAL OF IMMUNOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

(2008) Magali Irla et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY