Emerging central and peripheral actions of spexin in feeding behavior, leptin resistance and obesity

Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

(2022) Bora Jeong et al.   Biomolecules

Effects of intracerebroventricular injection of spexin and its interaction with NPY, GalR2 and GalR3 receptors on the central food intake regulation and nutritional behavior in broiler chickens

(2022) Mohaya Farzin et al.   NEUROSCIENCE LETTERS

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

(2022) Jia Duan et al.   Nature Communications

Serum spexin concentration, body condition score and markers of obesity in dogs

(2021) Pawel Antoni Kolodziejski et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2

(2021) Mervat H. El-Saka et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Effect of Fasting on the Spexin System in Broiler Chickens

(2021) Paweł A. Kołodziejski et al.   Animals

Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ and AMPK and inhibiting IL-6 and TNF-α

(2021) Mona A. Said et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Central and peripheral leptin resistance in obesity and improvements of exercise

(2021) Jin Peng et al.   HORMONES AND BEHAVIOR

Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease

(2021) Seema Kumar et al.   INTERNATIONAL JOURNAL OF OBESITY

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

Adipose tissue spexin in physical exercise and age-associated diseases

(2021) Penghua Fang et al.   AGEING RESEARCH REVIEWS

Effect of Exercise Training on Spexin Level, Appetite, Lipid Accumulation Product, Visceral Adiposity Index, and Body Composition in Adults With Type 2 Diabetes

(2021) Arash Mohammadi et al.   Biological Research for Nursing

Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor

(2021) Mei Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

(2021) Muhammad Sufyan Vohra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

(2021) Pawel A. Kolodziejski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo

(2021) Natalia Leciejewska et al.   Genes

Decreased levels of spexin are associated with hormonal and metabolic disturbance in subjects with polycystic ovary syndrome

(2020) Aslı Guler et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus

(2020) Seyda Yavuzkir et al.   PEPTIDES

Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors

(2020) Yoo-Na Lee et al.   PLoS One

“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”

(2020) Sabrina Eliana Gambaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Peripheral Spexin Inhibited Food Intake in Mice

(2020) Shuangyu Lv et al.   International Journal of Endocrinology

Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes

(2020) Abdelkrim Khadir et al.   Scientific Reports

Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats

(2020) L. Guo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men

(2020) Halil İbrahim Ceylan et al.   CHRONOBIOLOGY INTERNATIONAL

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4

(2020) Lu Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Are spexin levels associated with metabolic syndrome, dietary intakes and body composition in children?

(2020) Maryam Behrooz et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

Serum levels of spexin are increased in the third trimester pregnancy with gestational diabetes mellitus

(2019) Murat Akbas et al.   GYNECOLOGICAL ENDOCRINOLOGY

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

(2019) Seongsik Yun et al.   Frontiers in Neuroscience

Emerging Roles of NPQ/Spexin in Physiology and Pathology

(2019) Shuang-Yu Lv et al.   Frontiers in Pharmacology

Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus

(2019) Este Leidmaa et al.   Acta Physiologica

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes

(2019) Nasser M. Al-Daghri et al.   Scientific Reports

Evolution of Structural and Functional Diversity of Spexin in Mammalian and Non-mammalian Vertebrate Species

(2019) Chor Hong Lim et al.   Frontiers in Endocrinology

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

(2019) Yang Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Galanin peptide family regulation of glucose metabolism

(2019) Penghua Fang et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons

(2019) Andy Tran et al.   NEUROSCIENCE

Different Spexin level in Obese vs Normal Weight Children and Its Relationship with Obesity Related Risk Factors

(2019) Maryam Behrooz et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents

(2019) Flora Bacopoulou et al.   Journal of Clinical Medicine

Circulating spexin levels are influenced by the presence or absence of gestational diabetes

(2018) Nasser M. Al-Daghri et al.   CYTOKINE

Activiated galanin receptor 2 attenuates insulin resistance in skeletal muscle of obese mice

(2018) Penghua Fang et al.   PEPTIDES

Roux en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin

(2018) Seema Kumar et al.   Surgery for Obesity and Related Diseases

Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus

(2018) Nasser M. Al-Daghri et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats

(2018) Penghua Fang et al.   BIOCHEMICAL PHARMACOLOGY

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

(2018) Pawel A. Kolodziejski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spexin Levels Are Associated with Metabolic Syndrome Components

(2018) Nasser M. Al-Daghri et al.   DISEASE MARKERS

Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes

(2018) Anara Karaca et al.   MEDICAL PRINCIPLES AND PRACTICE

Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents

(2017) S Konnar Hodges et al.   PEDIATRIC DIABETES

Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study

(2017) Binbin Zheng et al.   Scientific Reports

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice

(2016) Arfaxad Reyes-Alcaraz et al.   Scientific Reports

Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fasting

(2015) Hongwei Wu et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

New insights in leptin resistance mechanisms in mice

(2015) Eglantine Balland et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Drug targeting of leptin resistance

(2015) Anna Santoro et al.   LIFE SCIENCES

Leptin resistance and diet-induced obesity: central and peripheral actions of leptin

(2015) Neira Sáinz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via Galanin Receptor 2 in Mice

(2015) Cheng-yuan Lin et al.   Scientific Reports

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

(2014) Dong-Kyu Kim et al.   ENDOCRINOLOGY

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control

(2013) Matthew K. H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

(2012) Zhenwen Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish

(2012) J.W. Prokop et al.   PEPTIDES

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

C12ORF39, a novel secreted protein with a typical amidation processing signal

(2009) Bingbing Wan et al.   BIOSCIENCE REPORTS

Adipocytokines: A bridge connecting obesity and insulin resistance

(2009) Xiao-Feng Zhuang et al.   MEDICAL HYPOTHESES

Evolutionary Sequence Modeling for Discovery of Peptide Hormones

(2009) Kemal Sonmez et al.   PLoS Computational Biology