Neuronal G protein-gated K+ channels

A novel small molecule selective activator of homomeric GIRK4 channels

(2022) Meng Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of acute and persistent excitation of prelimbic pyramidal neurons on motor activity and trace fear learning

(2021) Timothy R. Rose et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system

(2021) Danko Jeremic et al.   PHARMACOLOGY & THERAPEUTICS

Advances in Targeting GIRK Channels in Disease

(2021) Yulin Zhao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

(2021) Ikuo Masuho et al.   Cell Systems

Next-generation inward rectifier potassium channel modulators: Discovery and molecular pharmacology

(2021) C. David Weaver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Remifentanil self-administration in mice promotes sex-specific prefrontal cortex dysfunction underlying deficits in cognitive flexibility

(2021) Eden M. Anderson et al.   NEUROPSYCHOPHARMACOLOGY

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

(2021) Takuya Hikima et al.   Cell Reports

The Role of Parvalbumin Interneuron GIRK Signaling in the Regulation of Affect and Cognition in Male and Female Mice

(2021) Eden M. Anderson et al.   Frontiers in Behavioral Neuroscience

Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior

(2021) Baovi N. Vo et al.   JOURNAL OF NEUROSCIENCE

G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice

(2021) Souhail Djebari et al.   JOURNAL OF NEUROSCIENCE

Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice

(2021) Eden M. Anderson et al.   NEUROPSYCHOPHARMACOLOGY

Infralimbic cortex pyramidal neuron GIRK signaling contributes to regulation of cognitive flexibility but not affect-related behavior in male mice.

(2021) Eden M Anderson et al.   PHYSIOLOGY & BEHAVIOR

Structural insights into GIRK2 channel modulation by cholesterol and PIP2

(2021) Yamuna Kalyani Mathiharan et al.   Cell Reports

The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease

(2021) Rocío Alfaro-Ruiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Innovations and advances in modelling and measuring pain in animals

(2021) Katelyn E. Sadler et al.   NATURE REVIEWS NEUROSCIENCE

Structural Characterization of the Highly Restricted Down Syndrome Critical Region on 21q22.13: New KCNJ6 and DSCR4 Transcript Isoforms

(2021) Francesca Antonaros et al.   Frontiers in Genetics

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents

(2020) Yu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling

(2020) Xiaofan Li et al.   JOURNAL OF NEUROSCIENCE

Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators

(2020) Kenneth B. Walsh   SLAS Discovery

Identification of a G-Protein-Independent Activator of GIRK Channels

(2020) Yulin Zhao et al.   Cell Reports

A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

(2020) Shai Berlin et al.   Frontiers in Pharmacology

Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

(2020) Jennifer Mayordomo-Cava et al.   Biology-Basel

An etiological Foxp2 mutation impairs neuronal gain in layer VI cortico-thalamic cells through increased GABAB/GIRK signaling

(2020) Mélanie Druart et al.   JOURNAL OF NEUROSCIENCE

Antinociceptive effect of selective G protein-gated inwardly rectifying K+ channel agonist ML297 in the rat spinal cord

(2020) Masami Kimura et al.   PLoS One

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

(2020) Yiming Niu et al.   eLife

Reduced activity of GIRK1‐containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory

(2020) Alice Mett et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner

(2019) Galit Tabak et al.   Scientific Reports

Structural basis for KCTD-mediated rapid desensitization of GABAB signalling

(2019) Sanduo Zheng et al.   NATURE

GIRK channel activity in dopamine neurons of the ventral tegmental area bi-directionally regulates behavioral sensitivity to cocaine

(2019) Nora M. McCall et al.   JOURNAL OF NEUROSCIENCE

Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid-β Pathology

(2019) Irene Sánchez-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KCNJ6 variants modulate reward‐related brain processes and impact executive functions in attention‐deficit/hyperactivity disorder

(2019) Georg C. Ziegler et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The organizing principle of GABA B receptor complexes: Physiological and pharmacological implications

(2019) Thorsten Fritzius et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

VU0810464, a non‐urea GIRK channel activator, exhibits enhanced selectivity for neuronal GIRK channels and reduces stress‐induced hyperthermia in mice

(2019) Baovi N. Vo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

(2019) Hanaho Kano et al.   Nature Communications

Receptor-specific regulation of atrial GIRK channel activity by different Ca2+-dependent PKC isoforms

(2019) Anne Niemeyer et al.   CELLULAR SIGNALLING

The Neuroscience of Drug Reward and Addiction

(2019) Nora D. Volkow et al.   PHYSIOLOGICAL REVIEWS

On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer

(2019) Dailin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive

(2019) Aguan D. Wei et al.   Frontiers in Physiology

Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying potassium channel activity

(2019) Irene Sánchez‐Rodríguez et al.   JOURNAL OF NEUROCHEMISTRY

Role of A1 receptor-activated GIRK channels in the suppression of hippocampal seizure activity

(2019) Emily Hill et al.   NEUROPHARMACOLOGY

GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297

(2018) Yian Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Kcnj6 (GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome

(2018) Krutika Joshi et al.   EPILEPSY RESEARCH

Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice

(2018) Ikutaro Honda et al.   NEUROSCIENCE LETTERS

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

(2018) Krystian A. Kozek et al.   ACS Chemical Neuroscience

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization

(2018) Robert A. Rifkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

(2018) Kristopher K. Abney et al.   ACS Chemical Neuroscience

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels

(2018) Anna N. Bukiya et al.   JOURNAL OF LIPID RESEARCH

Diterpenoids from Euphorbia dulcis with Potassium Ion Channel Inhibitory Activity with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effect

(2018) Norbert Kúsz et al.   JOURNAL OF NATURAL PRODUCTS

Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7

(2018) Olga I. Ostrovskaya et al.   JOURNAL OF NEUROSCIENCE

Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleep

(2018) Bende Zou et al.   SLEEP

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

(2018) Dipak N Patil et al.   eLife

Collision coupling in the GABAB receptor-G protein-GIRK signaling cascade

(2017) Uri Kahanovitch et al.   FEBS LETTERS

Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus

(2017) Anna N. Bukiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic role of the tether helix in PIP 2 -dependent gating of a G protein–gated potassium channel

(2017) Emre Lacin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dendritic GIRK Channels Gate the Integration Window, Plateau Potentials, and Induction of Synaptic Plasticity in Dorsal But Not Ventral CA1 Neurons

(2017) Ruchi Malik et al.   JOURNAL OF NEUROSCIENCE

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

(2017) Alexander M. Kleschevnikov et al.   NEUROBIOLOGY OF DISEASE

Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core

(2017) Ezequiel Marron Fernandez de Velasco et al.   NEUROPHARMACOLOGY

Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability

(2017) Sudarat Nimitvilai et al.   NEUROPSYCHOPHARMACOLOGY

G Protein-Gated Potassium Channels: A Link to Drug Addiction

(2017) Robert A. Rifkin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior

(2017) Ezequiel Marron Fernandez de Velasco et al.   Scientific Reports

G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

(2017) Linda M. May et al.   Frontiers in Neuroscience

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

(2017) Ian W. Glaaser et al.   Scientific Reports

Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology

(2017) Irene Sánchez-Rodríguez et al.   Scientific Reports

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward

(2016) Megan E. Tipps et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

(2016) Gaspard Montandon et al.   ANESTHESIOLOGY

Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel

(2016) Krutika Joshi et al.   ANNALS OF NEUROLOGY

G Protein-Gated K + Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning

(2016) Nicole C. Victoria et al.   BIOLOGICAL PSYCHIATRY

Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner

(2016) S. Rezania et al.   BMC CANCER

Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

(2016) Andrea Vasas et al.   JOURNAL OF NATURAL PRODUCTS

A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons

(2016) M. B. Munoz et al.   JOURNAL OF NEUROSCIENCE

KCTD Hetero-oligomers Confer Unique Kinetic Properties on Hippocampal GABA B Receptor-Induced K + Currents

(2016) Thorsten Fritzius et al.   JOURNAL OF NEUROSCIENCE

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

(2016) Salvatore Lecca et al.   NATURE MEDICINE

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

(2016) Nora M McCall et al.   NEUROPSYCHOPHARMACOLOGY

Calcium Release from Stores Inhibits GIRK

(2016) Paul F. Kramer et al.   Cell Reports

Keppen-Lubinsky Syndrome Is Caused by Mutations in the Inwardly Rectifying K+ Channel Encoded by KCNJ6

(2015) Andrea Masotti et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Networks of protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse

(2015) Goran Mucic et al.   BEHAVIOURAL BRAIN RESEARCH

Cholesterol increases the open probability of cardiac KACh currents

(2015) Anna N. Bukiya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pyramidal Cell Selective Ablation of N-Methyl-D-Aspartate Receptor 1 Causes Increase in Cellular and Network Excitability

(2015) Valerie M. Tatard-Leitman et al.   BIOLOGICAL PSYCHIATRY

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain

(2015) Cesare Orlandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus

(2015) Chung Sub Kim et al.   JOURNAL OF NEUROPHYSIOLOGY

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

(2015) S. K. Adney et al.   JOURNAL OF NEUROSCIENCE

GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner

(2015) L. Kotecki et al.   JOURNAL OF NEUROSCIENCE

Rapid antidepressants stimulate the decoupling of GABAB receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η

(2015) E R Workman et al.   MOLECULAR PSYCHIATRY

Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus

(2015) Jennifer Mayordomo-Cava et al.   PLoS One

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol

(2015) Melissa A. Herman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methamphetamine Self-Administration in Mice Decreases GIRK Channel-Mediated Currents in Midbrain Dopamine Neurons

(2015) A. L. Sharpe et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The GABABreceptor associates with regulators of G-protein signaling 4 protein in the mouse prefrontal cortex and hypothalamus

(2014) Gyeongwha Kim et al.   BMB Reports

Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT1A receptor-adenylyl cyclase axis

(2014) Adele Stewart et al.   FASEB JOURNAL

Postsynaptic GABA B Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory

(2014) Miho Terunuma et al.   JOURNAL OF NEUROSCIENCE

Firing Modes of Dopamine Neurons Drive Bidirectional GIRK Channel Plasticity

(2014) A. L. Lalive et al.   JOURNAL OF NEUROSCIENCE

Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

(2014) Daisuke Nishizawa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1

(2014) Uri Kahanovitch et al.   JOURNAL OF PHYSIOLOGY-LONDON

5-Hydroxytryptamine1Areceptor-activation hyperpolarizes pyramidal cells and suppresses hippocampal gamma oscillations via Kir3 channel activation

(2014) April Johnston et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297

(2014) N. Wydeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kir3 channel signaling complexes: focus on opioid receptor signaling

(2014) Karim Nagi et al.   Frontiers in Cellular Neuroscience

Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study

(2014) Tsuyoshi Sasaki et al.   Neuropsychiatric Disease and Treatment

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

(2014) Olga Ostrovskaya et al.   eLife

ML297 (VU0456810), the First Potent and Selective Activator of the GIRK Potassium Channel, Displays Antiepileptic Properties in Mice

(2013) Kristian Kaufmann et al.   ACS Chemical Neuroscience

Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase

(2013) Fritz Treiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Association of Rgs7/Gβ5 complexes with girk channels and GABABreceptors in hippocampal CA1 pyramidal neurons

(2013) Ana Fajardo-Serrano et al.   HIPPOCAMPUS

Macromolecular Composition Dictates Receptor and G Protein Selectivity of Regulator of G Protein Signaling (RGS) 7 and 9-2 Protein Complexes in Living Cells

(2013) Ikuo Masuho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

(2013) Nicole Wydeven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex

(2013) Matthew Hearing et al.   NEURON

Tipepidine activates VTA dopamine neuron via inhibiting dopamine D2 receptor-mediated inward rectifying K+ current

(2013) R. Hamasaki et al.   NEUROSCIENCE

Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes

(2013) Stephen Bruehl et al.   PAIN

Ras-Association Domain of Sorting Nexin 27 Is Critical for Regulating Expression of GIRK Potassium Channels

(2013) Bartosz Balana et al.   PLoS One

Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels

(2013) K. Bodhinathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the therapeutic potential of Girk channels

(2013) Rafael Luján et al.   TRENDS IN NEUROSCIENCES

Amyloid-β induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse

(2013) Mauricio O. Nava-Mesa et al.   Frontiers in Cellular Neuroscience

Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions

(2012) Sophie Laffray et al.   EMBO JOURNAL

Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ6

(2012) S. J. Kang et al.   GENES BRAIN AND BEHAVIOR

Structural Basis for Modulation of Gating Property of G Protein-gated Inwardly Rectifying Potassium Ion Channel (GIRK) by i/o-family G Protein α Subunit (Gαi/o)

(2012) Yoko Mase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes

(2012) Cesare Orlandi et al.   JOURNAL OF CELL BIOLOGY

Repeated Stress Dysregulates  -Opioid Receptor Signaling in the Dorsal Raphe through a p38  MAPK-Dependent Mechanism

(2012) J. C. Lemos et al.   JOURNAL OF NEUROSCIENCE

Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA

(2012) Claire L. Padgett et al.   NEURON

Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity

(2012) N. Wydeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

(2012) A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system

(2012) Matthew C. Hearing et al.   REVIEWS IN THE NEUROSCIENCES

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by Phencyclidine

(2011) Toru Kobayashi et al.   Current Neuropharmacology

Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population

(2011) Kazuo Yamada et al.   HUMAN GENETICS

Regulator of G Protein Signaling 6 (RGS6) Protein Ensures Coordination of Motor Movement by Modulating GABABReceptor Signaling

(2011) Biswanath Maity et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Roles for G-protein γ3and γ7Subtypes in Seizure Susceptibility as Revealed in Double Knock-out Mice

(2011) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalization of the GABAB Receptor Signaling Complex Is Required for Presynaptic Inhibition at Hippocampal Synapses

(2011) T. Laviv et al.   JOURNAL OF NEUROSCIENCE

Acute Cocaine Exposure Weakens GABAB Receptor-Dependent G-Protein-Gated Inwardly Rectifying K+ Signaling in Dopamine Neurons of the Ventral Tegmental Area

(2011) D. Arora et al.   JOURNAL OF NEUROSCIENCE

In Vivo Ethanol Experience Increases D2 Autoinhibition in the Ventral Tegmental Area

(2011) Simona Perra et al.   NEUROPSYCHOPHARMACOLOGY

KCNJ6 is Associated with Adult Alcohol Dependence and Involved in Gene × Early Life Stress Interactions in Adolescent Alcohol Drinking

(2011) Toni-Kim Clarke et al.   NEUROPSYCHOPHARMACOLOGY

Regulators of G-Protein Signaling and Their G  Substrates: Promises and Challenges in Their Use as Drug Discovery Targets

(2011) A. J. Kimple et al.   PHARMACOLOGICAL REVIEWS

Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents

(2011) Leonardo M. Loscalzo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Genome-Wide Association Study of Schizophrenia in Japanese Population

(2011) Kazuo Yamada et al.   PLoS One

Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by Different Classes of Antidepressants

(2011) Toru Kobayashi et al.   PLoS One

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate

(2010) Ekaterina Posokhova et al.   CIRCULATION RESEARCH

RGS6, a Modulator of Parasympathetic Activation in Heart

(2010) Jianqi Yang et al.   CIRCULATION RESEARCH

Ginsenosides and Their CNS Targets

(2010) Khaled Radad et al.   CNS Neuroscience & Therapeutics

Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits

(2010) Francisco Ciruela et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Epistatic interaction of CREB1 and KCNJ6 on rumination and negative emotionality

(2010) Judit Lazary et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cloning and characterisation of GIRK1 variants resulting from alternative RNA editing of the KCNJ3 gene transcript in a human breast cancer cell line

(2010) Valerie Wagner et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Altered neurotransmission in the mesolimbic reward system of Girk−/− mice

(2010) Devinder Arora et al.   JOURNAL OF NEUROCHEMISTRY

Morphine- and CaMKII-Dependent Enhancement of GIRK Channel Signaling in Hippocampal Neurons

(2010) R. Nassirpour et al.   JOURNAL OF NEUROSCIENCE

Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

(2010) Keqiang Xie et al.   NATURE NEUROSCIENCE

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size

(2010) Jörn Lötsch et al.   Pharmacogenetics and Genomics

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

A Novel Antidepressant-like Action of Drugs Possessing GIRK Channel Blocking Action in Rats

(2010) Kazuaki KAWAURA et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Keppen-Lubinsky syndrome: Expanding the phenotype

(2009) Lina Basel-Vanagaite et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling

(2009) Garret R. Anderson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase

(2009) Carmen Müllner et al.   FEBS Journal

Gαiand Gβγ Jointly Regulate the Conformations of a Gβγ Effector, the Neuronal G Protein-activated K+Channel (GIRK)

(2009) Shai Berlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Phosphorylation of Kir3 following κ-Opioid Receptor Activation of p38 MAPK Causes Heterologous Desensitization

(2009) Cecilea C. Clayton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping a Barbiturate Withdrawal Locus to a 0.44 Mb Interval and Analysis of a Novel Null Mutant Identify a Role for Kcnj9 (GIRK3) in Withdrawal from Pentobarbital, Zolpidem, and Ethanol

(2009) L. B. Kozell et al.   JOURNAL OF NEUROSCIENCE

Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+channel by GαiGDPand Gβγ

(2009) Moran Rubinstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

A discrete alcohol pocket involved in GIRK channel activation

(2009) Prafulla Aryal et al.   NATURE NEUROSCIENCE

Molecular Mechanisms of Go Signaling

(2009) Meisheng Jiang et al.   NEUROSIGNALS

Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit

(2009) Radda Rusinova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Association between KCNJ6 (GIRK2) Gene Polymorphisms and Postoperative Analgesic Requirements after Major Abdominal Surgery

(2009) Daisuke Nishizawa et al.   PLoS One

Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels

(2009) H. J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation

(2009) H. J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioral characterization of mice lacking GIRK/Kir3 channel subunits

(2008) M. Pravetoni et al.   GENES BRAIN AND BEHAVIOR

Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum

(2008) Carolina Aguado et al.   JOURNAL OF NEUROCHEMISTRY

Absence and Rescue of Morphine Withdrawal in GIRK/Kir3 Knock-out Mice

(2008) H. G. Cruz et al.   JOURNAL OF NEUROSCIENCE

GPCR-Kir Channel Signaling Complexes: Defining Rules of Engagement

(2008) CRAIG A. DOUPNIK   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Crystal structure of the multifunctional Gβ5–RGS9 complex

(2008) Matthew L Cheever et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus

(2008) A.N. Pietersen et al.   NEUROPHARMACOLOGY

Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels

(2008) Shachar Iwanir et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes

(2008) Shad B. Smith et al.   Pharmacogenetics and Genomics

Predisposition to late-onset obesity in GIRK4 knockout mice

(2008) C. A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA