Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

(2020) Allison Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Global Map of G Protein Signaling Regulation by RGS Proteins

(2020) Ikuo Masuho et al.   CELL

Live cell optical assay for precise characterization of receptors coupling to Gα12

(2019) Ikuo Masuho et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

(2019) Alan V. Smrcka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Emerging Role of Gβ Subunits in Human Genetic Diseases

(2019) Natascia Malerba et al.   Cells

Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

Gγ identity dictates efficacy of Gβγ signaling and macrophage migration

(2018) Kanishka Senarath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

(2018) Sahil Gulati et al.   Nature Communications

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits

(2018) Brian S. Muntean et al.   Cell Reports

Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila

(2017) Sophie Himmelreich et al.   Cell Reports

Mechanistic insights into GPCR–G protein interactions

(2016) Jacob P Mahoney et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Gβγ subunits—Different spaces, different faces

(2016) Shahriar M. Khan et al.   PHARMACOLOGICAL RESEARCH

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

(2015) S. Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution

(2015) Matthias Hillenbrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia

(2014) Yuanchao Ye et al.   CELLULAR SIGNALLING

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Macromolecular Composition Dictates Receptor and G Protein Selectivity of Regulator of G Protein Signaling (RGS) 7 and 9-2 Protein Complexes in Living Cells

(2013) Ikuo Masuho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterotrimeric G Protein Subunit G 13 Is Critical to Olfaction

(2013) F. Li et al.   JOURNAL OF NEUROSCIENCE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells

(2013) A. Majumder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

All G protein βγ complexes are capable of translocation on receptor activation

(2012) W.K. Ajith Karunarathne et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G-protein signaling leverages subunit-dependent membrane affinity to differentially control    translocation to intracellular membranes

(2012) P. R. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitive and High Resolution Localization and Tracking of Membrane Proteins in Live Cells with BRET

(2012) Tien-Hung Lan et al.   TRAFFIC

Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

(2010) Adi Raveh et al.   CELL

Adenosine A2AReceptor Signaling and GolfAssembly Show a Specific Requirement for the γ7Subtype in the Striatum

(2010) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Golgi structure and secretion by receptor-induced G protein    complex translocation

(2010) D. K. Saini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion

(2010) Juan Zhang et al.   Nature Communications

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING

Regulation of G-Protein Signaling by RKTG via Sequestration of the G   Subunit to the Golgi Apparatus

(2009) Y. Jiang et al.   MOLECULAR AND CELLULAR BIOLOGY

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Shuttling and translocation of heterotrimeric G proteins and Ras

(2009) Deepak K. Saini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

(2009) Claire Fenech   Frontiers in Cellular Neuroscience

The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

(2008) Denis J. Dupré et al.   Annual Review of Pharmacology and Toxicology

G Protein-coupled Receptor-promoted Trafficking of Gβ1γ2 Leads to AKT Activation at Endosomes via a Mechanism Mediated by Gβ1γ2-Rab11a Interaction

(2008) Alejandro García-Regalado et al.   MOLECULAR BIOLOGY OF THE CELL