Article
Pharmacology & Pharmacy
Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li
Summary: Caffeine as a nonspecific antagonist of the adenosine A(2A) receptor enhances learning and memory function while also correlating with feelings of anxiety. The differential effects of inhibiting A(2A)Rs in the dorsal and ventral hippocampus lead to enhanced memory and increased anxiety, respectively. Optogenetic activation of dorsal or ventral hippocampal A(2A)Rs can reverse these behavioral alterations caused by caffeine intake.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Alexandra Hencz, Andor Magony, Chloe Thomas, Krisztina Kovacs, Gabor Szilagyi, Jozsef Pal, Attila Sik
Summary: Hypoxia causes changes in the hippocampus, including injury to inhibitory neurons and alterations in network activity. These changes may affect information processing.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Lindsey M. Crown, Daniel T. Gray, Lesley A. Schimanski, Carol A. Barnes, Stephen L. Cowen
Summary: This study investigates the effects of locomotor activity and age on gamma and theta frequencies in the hippocampus of rats. The results show that age affects the modulation of gamma and theta frequencies, with older rats showing slower increases in gamma frequency and lower theta frequencies. Acceleration is also found to have a lower correlation with gamma frequency in both age groups. Older animals have greater spike phase-locking to gamma and reduced firing rates within place fields, but higher spatial information content per spike. These findings suggest that locomotor behavior and age significantly impact local-field potential activity in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Moderate coffee consumption has beneficial effects on various liver diseases, possibly by inhibiting adenosine binding to its receptors. Caffeine is considered a potential drug for the prevention and treatment of liver diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aisling Leavy, Gary P. Brennan, Eva M. Jimenez-Mateos
Summary: Brain development occurs until adulthood, with time-sensitive processes happening during embryo development, childhood, and puberty. MicroRNAs, small non-coding RNAs that regulate gene expression, play a crucial role in brain maturation. This study analyzed the microRNA profile in the hippocampus of mice during postnatal development and after hypoxia at birth, and found that their expression may be regulated by the transcriptional regulator c-myc.
Article
Neurosciences
Simo Ojanen, Tatiana Kuznetsova, Zoia Kharybina, Vootele Voikar, Sari E. E. Lauri, Tomi Taira
Summary: The absence of GluK1 containing KARs in GABAergic interneurons disrupts GABAergic neurotransmission and spontaneous network activity in the neonatal hippocampus, while leading to stronger hippocampal gamma oscillations and enhanced theta-gamma cross frequency coupling in adult male mice. In females, loss of interneuronal GluK1 results in shorter sharp wave ripple oscillations and slightly impaired abilities in flexible sequencing tasks.
Article
Biochemistry & Molecular Biology
Catia R. Lopes, Andreia Oliveira, Ingride Gaspar, Matilde S. Rodrigues, Joana Santos, Eszter Szabo, Henrique B. Silva, Aangelo R. Tome, Paula M. Canas, Paula Agostinho, Rui A. Carvalho, Rodrigo A. Cunha, Ana Patricia Simoes, Joao Pedro Lopes, Samira G. Ferreira
Summary: Moderate caffeine intake can antagonize adenosine receptors and protect neurons without affecting behavior and synaptic plasticity. It increases the metabolic competence of synapses and enhances their antioxidant capacity.
Article
Medicine, Research & Experimental
Johanna C. Arroyave-Ospina, Manon Buist-Homan, Martina Schmidt, Han Moshage
Summary: This study found that caffeine can protect liver cells from the toxic effects of fatty acids by modulating adenosine receptor signaling. By activating protein kinase A and inhibiting the A1AR receptor, caffeine can reduce lipid accumulation and harmful substances produced by mitochondria, thereby alleviating metabolic dysfunction-associated liver disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Loescher
Summary: The authors proposed a novel approach involving multiple targets and networks, combining drugs to prevent the onset of epilepsy, and provided initial evidence of its effectiveness.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ruth Mae McLeod, Ted S. Rosenkrantz, Roslyn Holly Fitch, Rachel R. Koski
Summary: Preterm infants are often given caffeine as a respiratory stimulant, but it has also been found to have neuroprotective potential. This study investigated the effects of caffeine on microglial activation in rodent brains after hypoxic ischemic injury. The results suggest that caffeine offers protective effects by reducing cell death, but the mechanism may be different between males and females.
Article
Neurosciences
Adam Gorlewicz, Gael Barthet, Stefano Zucca, Peggy Vincent, Marilena Griguoli, Noelle Grosjean, Grzegorz Wilczynski, Christophe Mulle
Summary: Kainate receptors (KARs) play a crucial role in regulating synaptic circuits through ionotropic or metabotropic mechanisms. This study reveals that the acute convulsive effect of kainate is primarily dependent on GluK2/GluK5 containing KARs, while the convulsive activity induced by pilocarpine and pentylenetetrazol is not affected by the absence of KARs. Interestingly, the genetic inactivation of GluK2 increases susceptibility to acute pilocarpine-induced seizures.
Article
Neurosciences
Benton S. Purnell, Sydney Thompson, Tenise Bowman, Jayant Bhasin, Steven George, Brian Rust, Madhuvika Murugan, Denise Fedele, Detlev Boison
Summary: Alcohol-related poisoning is the leading cause of death due to excessive acute alcohol consumption. The pathophysiology of fatal alcohol poisoning involves respiratory failure. Adenosine signaling plays a role in alcohol-induced respiratory suppression. Understanding how alcohol affects breathing can lead to improved treatment strategies and outcomes for patients with severe alcohol poisoning.
Review
Neurosciences
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor
Summary: This article reviews the roles of kainate receptors in synaptic plasticity, focusing on their impact on postsynaptic signaling and presynaptic auto-receptor functions. It also explores the plasticity of kainate receptors themselves and their contribution to synaptic transmission plasticity.
Review
Pharmacology & Pharmacy
Emily Cash, Amanda T. Goodwin, Amanda L. Tatler
Summary: Pulmonary fibrosis is a debilitating lung condition caused by the abnormal activation of fibroblasts, resulting in the deposition of ECM components and impairment of lung function. Adenosine signalling is believed to play a role in tissue fibrosis, including in the lungs, but the exact molecular pathways are still unknown.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Alain Boussuges, Jeremy Bourenne, Farid Eloufir, Julien Fromonot, Giovanna Mottola, Jean Jacques Risso, Nicolas Vallee, Fabienne Bregeon, Regis Guieu
Summary: Exposure to extreme oxygen partial pressures can induce changes in the adenosinergic system, which play important roles in protecting the brain and lungs in high-altitude and deep-sea environments. Increased adenosine concentration helps protect the brain against hypoxia and is involved in the pathogenesis of mountain illness and neurological disorders. It also contributes to the prevention of high-altitude pulmonary edema and lung oxygen toxicity. On the other hand, decreased adenosine concentration during hyperoxic exposure leads to vasoconstriction and decreased cerebral blood flow, serving as a preventive measure against cerebral oxygen toxicity.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.