Dynamic role of the tether helix in PIP 2 -dependent gating of a G protein–gated potassium channel

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

(2017) Ian W. Glaaser et al.   Scientific Reports

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP 2 regulated pH i -gating

(2016) Chien-Hsing Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2levels

(2016) Gucan Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel

(2016) Xuan-Yu Meng et al.   Scientific Reports

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

(2015) S. K. Adney et al.   JOURNAL OF NEUROSCIENCE

Ion channel regulation by phosphoinositides analyzed with VSPs—PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility

(2015) Alexandra Rjasanow et al.   Frontiers in Pharmacology

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

(2014) Prafulla Aryal et al.   Nature Communications

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels

(2013) K. Bodhinathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels

(2013) Sun-Joo Lee et al.   Nature Communications

The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel

(2012) Xuan-Yu Meng et al.   BIOPHYSICAL JOURNAL

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Direct and Specific Activation of Human Inward Rectifier K+Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A discrete alcohol pocket involved in GIRK channel activation

(2009) Prafulla Aryal et al.   NATURE NEUROSCIENCE

New sites of action for GIRK and SK channels

(2009) Rafael Luján et al.   NATURE REVIEWS NEUROSCIENCE

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

(2009) X. Tao et al.   SCIENCE

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation