Nuclear migration events throughout development

Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators

(2016) Si Nie et al.   STRUCTURE

Matefin/SUN-1 Phosphorylation on Serine 43 Is Mediated by CDK-1 and Required for Its Localization to Centrosomes and Normal Mitosis in C. elegans Embryos

(2016) Noam Zuela et al.   Cells

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells

(2015) Alexandre D. Baffet et al.   DEVELOPMENTAL CELL

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

(2015) Inmaculada Navarro-Lérida et al.   DEVELOPMENTAL CELL

Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity

(2015) Paulina J. Strzyz et al.   DEVELOPMENTAL CELL

Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton

(2015) Manuela D’Alessandro et al.   DEVELOPMENTAL CELL

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion

(2015) Dustin G. Thomas et al.   JOURNAL OF CELL BIOLOGY

Accessorizing and anchoring the LINC complex for multifunctionality

(2015) Wakam Chang et al.   JOURNAL OF CELL BIOLOGY

Active diffusion positions the nucleus in mouse oocytes

(2015) Maria Almonacid et al.   NATURE CELL BIOLOGY

A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I

(2015) David Razafsky et al.   NEUROBIOLOGY OF DISEASE

RNAi Screening Identifies the Armadillo Repeat-Containing Kinesins Responsible for Microtubule-Dependent Nuclear Positioning in Physcomitrella patens

(2015) Tomohiro Miki et al.   PLANT AND CELL PHYSIOLOGY

CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells

(2015) Mika Toya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblasts Lead the Way: A Unified View of 3D Cell Motility

(2015) Ryan J. Petrie et al.   TRENDS IN CELL BIOLOGY

SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer

(2015) Xiao-bin Lv et al.   Scientific Reports

Moving and positioning the nucleus in skeletal muscle – one step at a time

(2015) Bruno Cadot et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1

(2015) Xiao Zhou et al.   Nucleus

Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer

(2015) Ayaka Matsumoto et al.   Cancer Medicine

Moving and positioning the nucleus in skeletal muscle – one step at a time

(2015) Bruno Cadot et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1

(2015) Xiao Zhou et al.   Nucleus

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

KASHing up with the nucleus: novel functional roles of KASH proteins at the cytoplasmic surface of the nucleus

(2014) GW Gant Luxton et al.   CURRENT OPINION IN CELL BIOLOGY

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells

(2014) M. H. Wilson et al.   DEVELOPMENT

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

(2014) S. Falcone et al.   EMBO Molecular Medicine

Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle

(2014) Mark A. Chapman et al.   HUMAN MOLECULAR GENETICS

The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture

(2014) Natalie E. Cain et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

A role for nuclear envelope–bridging complexes in homology-directed repair

(2014) Rebecca K. Swartz et al.   MOLECULAR BIOLOGY OF THE CELL

The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration

(2014) Courtney R. Bone et al.   MOLECULAR BIOLOGY OF THE CELL

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement

(2014) Stefan Kutscheidt et al.   NATURE CELL BIOLOGY

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nesprins: Tissue-Specific Expression of Epsilon and Other Short Isoforms

(2014) Nguyen Thuy Duong et al.   PLoS One

Efficient plant male fertility depends on vegetative nuclear movement mediated by two families of plant outer nuclear membrane proteins

(2014) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many modes of motility

(2014) D. W. DeSimone et al.   SCIENCE

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

(2014) Indroneal Banerjee et al.   PLoS Genetics

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

(2014) Peter Meinke et al.   PLoS Genetics

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

Dynein Recruitment to Nuclear Pores Activates Apical Nuclear Migration and Mitotic Entry in Brain Progenitor Cells

(2013) Daniel Jun-Kit Hu et al.   CELL

Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing

(2013) S. F. Schoppmann et al.   CLINICAL CANCER RESEARCH

Myosin XI-i Links the Nuclear Membrane to the Cytoskeleton to Control Nuclear Movement and Shape in Arabidopsis

(2013) Kentaro Tamura et al.   CURRENT BIOLOGY

Translocating myonuclei have distinct leading and lagging edges that require Kinesin and Dynein

(2013) E. S. Folker et al.   DEVELOPMENT

The Par3/Par6/aPKC complex and epithelial cell polarity

(2013) Jia Chen et al.   EXPERIMENTAL CELL RESEARCH

Contribution of SUN1 Mutations to the Pathomechanism in Muscular Dystrophies

(2013) Ping Li et al.   HUMAN MUTATION

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton

(2013) Henning F. Horn et al.   JOURNAL OF CELL BIOLOGY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

The LINC complex is essential for hearing

(2013) Henning F. Horn et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts

(2013) Wakam Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Using Whole-Exome Sequencing to Identify Inherited Causes of Autism

(2013) Timothy W. Yu et al.   NEURON

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nesprins in health and disease

(2013) Sarah Cartwright et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

(2013) Allison B. Chambliss et al.   Scientific Reports

Nuclear positioning in muscle development and disease

(2013) Eric S. Folker et al.   Frontiers in Physiology

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

(2012) Brian A. Sosa et al.   CELL

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

(2012) Chia-Yen Chen et al.   CELL

Structural insights into SUN-KASH complexes across the nuclear envelope

(2012) Wenjia Wang et al.   CELL RESEARCH

Localized Products of futile cycle/ lrmp Promote Centrosome-Nucleus Attachment in the Zebrafish Zygote

(2012) Robin E. Lindeman et al.   CURRENT BIOLOGY

Inner Nuclear Envelope Proteins SUN1 and SUN2 Play a Prominent Role in the DNA Damage Response

(2012) Kai Lei et al.   CURRENT BIOLOGY

Laminopathies: Too Much SUN Is a Bad Thing

(2012) Daniel A. Starr   CURRENT BIOLOGY

Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

(2012) Erin C Tapley et al.   CURRENT OPINION IN CELL BIOLOGY

Muscle length and myonuclear position are independently regulated by distinct Dynein pathways

(2012) E. S. Folker et al.   DEVELOPMENT

Interkinetic nuclear migration: A mysterious process in search of a function

(2012) Philip C. Spear et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Apical movement during interkinetic nuclear migration is a two-step process

(2012) Philip C. Spear et al.   DEVELOPMENTAL BIOLOGY

Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

(2012) Bruno Cadot et al.   EMBO REPORTS

toca-1 Is in a Novel Pathway That Functions in Parallel with a SUN-KASH Nuclear Envelope Bridge to Move Nuclei in Caenorhabditis elegans

(2012) Y.-T. Chang et al.   GENETICS

Novel plant SUN–KASH bridges are involved in RanGAP anchoring and nuclear shape determination

(2012) Xiao Zhou et al.   JOURNAL OF CELL BIOLOGY

A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis

(2012) Akihiro Morimoto et al.   JOURNAL OF CELL BIOLOGY

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Samp1 is a component of TAN lines and is required for nuclear movement

(2012) J. Borrego-Pinto et al.   JOURNAL OF CELL SCIENCE

Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells

(2012) Meredith H. Wilson et al.   JOURNAL OF CELL SCIENCE

Nuclear deformation during breast cancer cell transmigration

(2012) Yi Fu et al.   LAB ON A CHIP

Association at SYNE1 in both bipolar disorder and recurrent major depression

(2012) E K Green et al.   MOLECULAR PSYCHIATRY

MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function

(2012) Thomas Metzger et al.   NATURE

LINC Complexes Mediate the Positioning of Cone Photoreceptor Nuclei in Mouse Retina

(2012) David Razafsky et al.   PLoS One

Growing Microtubules Push the Oocyte Nucleus to Polarize the Drosophila Dorsal-Ventral Axis

(2012) T. Zhao et al.   SCIENCE

Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia

(2011) Emily J. Meyer et al.   CURRENT BIOLOGY

Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

(2011) Yoichi Kosodo et al.   EMBO JOURNAL

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

Centronuclear Myopathies

(2011) Norma B. Romero et al.   Seminars in Pediatric Neurology

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

ESR1/SYNE1 Polymorphism and Invasive Epithelial Ovarian Cancer Risk: An Ovarian Cancer Association Consortium Study

(2010) J. A. Doherty et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development

(2010) Juehua Yu et al.   HUMAN MOLECULAR GENETICS

Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei

(2010) Heidi N. Fridolfsson et al.   JOURNAL OF CELL BIOLOGY

Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

(2010) Jin-Wu Tsai et al.   NATURE NEUROSCIENCE

Centronuclear myopathies: A widening concept

(2010) Norma Beatriz Romero   NEUROMUSCULAR DISORDERS

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

(2010) E. S. Folker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Bicaudal D2, Dynein, and Kinesin-1 Associate with Nuclear Pore Complexes and Regulate Centrosome and Nuclear Positioning during Mitotic Entry

(2010) Daniël Splinter et al.   PLOS BIOLOGY

Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina

(2009) Caren Norden et al.   CELL

Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis

(2009) Aya Sato et al.   CELL

UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration

(2009) M. Meyerzon et al.   DEVELOPMENT

Centrosome attachment to the C. elegans male pronucleus is dependent on the surface area of the nuclear envelope

(2009) Marina Meyerzon et al.   DEVELOPMENTAL BIOLOGY

UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration

(2009) Heidi N. Fridolfsson et al.   DEVELOPMENTAL BIOLOGY

Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis

(2009) R. Attali et al.   HUMAN MOLECULAR GENETICS

Lamin A/C–mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy

(2009) Alexandre Méjat et al.   JOURNAL OF CELL BIOLOGY

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton

(2009) H. R. Dawe et al.   JOURNAL OF CELL SCIENCE

SUN-1 and ZYG-12, Mediators of Centrosome–Nucleus Attachment, Are a Functional SUN/KASH Pair in Caenorhabditis elegans

(2009) IL Minn et al.   MOLECULAR BIOLOGY OF THE CELL

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice

(2009) Xiaochang Zhang et al.   NEURON

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice

(2009) K. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of dynein in budding yeast: Mitotic spindle positioning in a polarized cell

(2009) Jeffrey K. Moore et al.   CELL MOTILITY AND THE CYTOSKELETON

Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice

(2008) M. J. Puckelwartz et al.   HUMAN MOLECULAR GENETICS

Nuclear migration during retinal development

(2007) Lisa M. Baye et al.   BRAIN RESEARCH