Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
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Title
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
Authors
Keywords
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Journal
Scientific Reports
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-03-02
DOI
10.1038/srep22540
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Note: Only part of the references are listed.- A first-in-human, phase I study of an oral hedgehog (HH) pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors.
- (2017) L. L. Siu et al. JOURNAL OF CLINICAL ONCOLOGY
- Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
- (2015) Scott X. Atwood et al. CANCER CELL
- A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors
- (2014) J. Rodon et al. CLINICAL CANCER RESEARCH
- Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus inDrosophila
- (2014) Kai Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
- (2014) Uwe Weierstall et al. Nature Communications
- Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
- (2013) A. Jimeno et al. CLINICAL CANCER RESEARCH
- Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma
- (2013) Katsura Emoto et al. HUMAN PATHOLOGY
- GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
- (2013) Scott X. Atwood et al. NATURE
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of a Novel Protein-Protein Interaction Motif Mediating Interaction of GPCR-Associated Sorting Proteins with G Protein-Coupled Receptors
- (2013) Olivier Bornert et al. PLoS One
- Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma
- (2012) Thomas Asklund et al. ACTA ONCOLOGICA
- Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube
- (2012) Nikolaos Balaskas et al. CELL
- Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
- (2012) Yu Wang et al. CHEMISTRY & BIOLOGY
- Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
- (2012) V. M. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Mechanisms and functions of Hedgehog signalling across the metazoa
- (2011) Philip W. Ingham et al. NATURE REVIEWS GENETICS
- A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model
- (2011) Martin F. Strand et al. PLoS One
- Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms
- (2011) Brahma N. Singh et al. PLoS One
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
- (2010) James Kim et al. CANCER CELL
- Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
- (2010) Stefan Peukert et al. ChemMedChem
- A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
- (2010) Hanna Tukachinsky et al. JOURNAL OF CELL BIOLOGY
- Molecular mechanisms of protein and lipid targeting to ciliary membranes
- (2010) B. T. Emmer et al. JOURNAL OF CELL SCIENCE
- The primary cilium: a signalling centre during vertebrate development
- (2010) Sarah C. Goetz et al. NATURE REVIEWS GENETICS
- The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling
- (2009) Tommaso Cupido et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
- (2009) Anita Büttner et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia
- (2009) E. S. Seeley et al. CANCER RESEARCH
- E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex
- (2009) Johannes von Burstin et al. GASTROENTEROLOGY
- Dual and opposing roles of primary cilia in medulloblastoma development
- (2009) Young-Goo Han et al. NATURE MEDICINE
- Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis
- (2009) Sunny Y Wong et al. NATURE MEDICINE
- The Hedgehog Pathway and Pancreatic Cancer
- (2009) Manuel Hidalgo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
- (2009) Charles M. Rudin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma
- (2008) Ulrich Schüller et al. CANCER CELL
- Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells
- (2008) Zeng-Jie Yang et al. CANCER CELL
- Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer
- (2008) J. M. Bailey et al. CLINICAL CANCER RESEARCH
- Hedgehog: functions and mechanisms
- (2008) M. Varjosalo et al. GENES & DEVELOPMENT
- Protein kinase C in the pancreatic acinar cell
- (2008) Fred Gorelick et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
- (2008) G. Feldmann et al. MOLECULAR CANCER THERAPEUTICS
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