Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?
Authors
Keywords
-
Journal
Journal of Personalized Medicine
Volume 12, Issue 4, Pages 542
Publisher
MDPI AG
Online
2022-03-30
DOI
10.3390/jpm12040542
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice
- (2022) Sarah K. Popp et al. JCI Insight
- Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial
- (2021) Robin Assfalg et al. DIABETOLOGIA
- Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals
- (2021) Emily K. Sims et al. Science Translational Medicine
- Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2021) Matthias von Herrath et al. Lancet Diabetes & Endocrinology
- Parallel Multi-Omics in High-Risk Subjects for the Identification of Integrated Biomarker Signatures of Type 1 Diabetes
- (2021) Oscar Alcazar et al. Biomolecules
- Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
- (2021) Teresa Rodriguez-Calvo et al. DIABETES
- Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum
- (2021) Alexia Carré et al. Frontiers in Immunology
- Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy
- (2021) Pauline Faucher et al. DIABETOLOGIA
- Novel neutrophil phenotypic signature in pediatric patients with type 1 diabetes and diabetic ketoacidosis
- (2021) Blake E Nichols et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes
- (2021) Noémie Corcos et al. Frontiers in Immunology
- The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes
- (2021) Shen Dong et al. JCI Insight
- CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes
- (2021) Marie Eliane Azoury et al. DIABETES
- Expression of CD47 in the pancreatic β‐cells of people with recent‐onset type 1 diabetes varies according to disease endotype
- (2021) Kaiyven Afi Leslie et al. DIABETIC MEDICINE
- An autoimmune stem-like CD8 T cell population drives type 1 diabetes
- (2021) Sofia V. Gearty et al. NATURE
- Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial
- (2020) Pieter F. de Groot et al. DIABETOLOGIA
- Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany
- (2020) Anette-Gabriele Ziegler et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison
- (2020) Cate Speake et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Type 1 diabetes—early life origins and changing epidemiology
- (2020) Jill M Norris et al. Lancet Diabetes & Endocrinology
- Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis
- (2020) Pia Leete et al. DIABETOLOGIA
- Immunotherapy Strategies for the Prevention and Treatment of Distinct Stages of Type 1 Diabetes: An Overview
- (2020) Novella Rapini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
- (2020) Hossam A. Abdelsamed et al. NATURE IMMUNOLOGY
- T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
- (2020) Eddie A. James et al. DIABETES
- Low-dose IL-2 in children with recently diagnosed type 1 diabetes: a Phase I/II randomised, double-blind, placebo-controlled, dose-finding study
- (2020) Michelle Rosenzwajg et al. DIABETOLOGIA
- Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes
- (2020) Ulf Hannelius et al. DIABETOLOGIA
- Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
- (2020) Natalie M. Edner et al. NATURE IMMUNOLOGY
- A combined risk score enhances prediction of type 1 diabetes among susceptible children
- (2020) Lauric A. Ferrat et al. NATURE MEDICINE
- Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.
- (2020) Marie Eliane Azoury et al. DIABETES
- Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
- (2020) Roberto Mallone et al. DIABETOLOGIA
- Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
- (2020) Alexia Carré et al. DIABETOLOGIA
- Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes
- (2020) Marika Falcone et al. Frontiers in Endocrinology
- Identifying the ‘Achilles Heel’ of type 1 diabetes
- (2020) Manuela Battaglia et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes
- (2020) Teresa Quattrin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
- (2020) Kirsten E. Diggins et al. JCI Insight
- Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
- (2019) Seth A. Sharp et al. DIABETES CARE
- Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression
- (2019) Tania Habib et al. DIABETES
- Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data
- (2019) Michael J. Haller et al. DIABETES
- Effect of prebiotic on microbiota, intestinal permeability and glycemic control in children with type 1 diabetes
- (2019) Josephine Ho et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes
- (2019) Kevan C. Herold et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells
- (2019) Jamie R.J. Inshaw et al. DIABETES CARE
- Immunomodulation Followed By Antigen-Specific Treg Infusion Controls Islet Autoimmunity
- (2019) Cecilia Cabello-Kindelan et al. DIABETES
- Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
- (2019) Manuela Battaglia et al. DIABETES CARE
- Advances in β-cell replacement therapy for the treatment of type 1 diabetes
- (2019) Marie-Christine Vantyghem et al. LANCET
- What the HLA-I!—Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes
- (2019) Rebecca C. Wyatt et al. Current Diabetes Reports
- Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian
- (2018) Yong Gu et al. ACTA DIABETOLOGICA
- Detection and Characterization of CD8+Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes
- (2018) Debora Vignali et al. DIABETES
- A selective CD28 antagonist and rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice
- (2018) Alix Besançon et al. DIABETOLOGIA
- Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
- (2018) Peter S. Linsley et al. GENES AND IMMUNITY
- Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
- (2018) Ezio Bonifacio et al. PLOS MEDICINE
- Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
- (2018) Sergio Gonzalez-Duque et al. Cell Metabolism
- The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
- (2018) Pia Leete et al. Current Diabetes Reports
- Pluripotent stem cell replacement approaches to treat type 1 diabetes
- (2018) Silvia Pellegrini et al. CURRENT OPINION IN PHARMACOLOGY
- Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes
- (2018) Susanne M. Cabrera et al. DIABETOLOGIA
- Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study
- (2018) Araz Rawshani et al. LANCET
- Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes
- (2018) Ciriana Orabona et al. TRENDS IN MOLECULAR MEDICINE
- Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
- (2018) Emily K. Sims et al. DIABETES CARE
- Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis
- (2018) Ana Luisa Perdigoto et al. DIABETOLOGIA
- Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine
- (2018) Bart O Roep et al. Lancet Diabetes & Endocrinology
- Understanding type 1 diabetes through proteomics
- (2017) Inne Crèvecoeur et al. Expert Review of Proteomics
- Adult-onset autoimmune diabetes: current knowledge and implications for management
- (2017) Raffaella Buzzetti et al. Nature Reviews Endocrinology
- Intralymphatic Injection of Autoantigen in Type 1 Diabetes
- (2017) Johnny Ludvigsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment
- (2017) Brittney N. Newby et al. Frontiers in Endocrinology
- Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes
- (2016) Pia Leete et al. DIABETES
- Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes
- (2016) Emily K. Sims et al. DIABETES CARE
- Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA 1c , and Insulin Dose
- (2016) Wei Hao et al. DIABETES CARE
- Life expectancy of type 1 diabetic patients during 1997–2010: a national Australian registry-based cohort study
- (2016) Lili Huo et al. DIABETOLOGIA
- Neutrophils in type 1 diabetes
- (2016) Juan Huang et al. Journal of Diabetes Investigation
- Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
- (2015) Slobodan Culina et al. DIABETES
- Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association
- (2015) Richard A. Insel et al. DIABETES CARE
- Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes
- (2015) Ezio Bonifacio et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
- (2015) Michelle Rosenzwajg et al. JOURNAL OF AUTOIMMUNITY
- Large-Scale Discovery and Validation Studies Demonstrate Significant Reductions in Circulating Levels of IL8, IL-1Ra, MCP-1, and MIP-1β in Patients With Type 1 Diabetes
- (2015) Sharad Purohit et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice
- (2015) J. N. Manirarora et al. JOURNAL OF IMMUNOLOGY
- The beta-cell in type 1 diabetes: What have we learned from proteomic studies?
- (2015) Inne Crèvecoeur et al. Proteomics Clinical Applications
- Type 1 diabetes immunotherapy using polyclonal regulatory T cells
- (2015) Jeffrey A. Bluestone et al. Science Translational Medicine
- A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
- (2014) R. C. Ferreira et al. DIABETES
- Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility
- (2014) H. Kallionpaa et al. DIABETES
- Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
- (2014) Sefina Arif et al. DIABETES
- Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes
- (2014) Michael J. Haller et al. JOURNAL OF CLINICAL INVESTIGATION
- Glycemic Control and Excess Mortality in Type 1 Diabetes
- (2014) Marcus Lind et al. NEW ENGLAND JOURNAL OF MEDICINE
- Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes
- (2013) A. Valle et al. DIABETES
- Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
- (2013) Mark R Rigby et al. Lancet Diabetes & Endocrinology
- Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
- (2013) Agnès Hartemann et al. Lancet Diabetes & Endocrinology
- Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
- (2013) Stephen E Gitelman et al. Lancet Diabetes & Endocrinology
- Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile
- (2012) W.-C. G. Yeung et al. DIABETES
- Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs -Cell Function
- (2012) S. A. Long et al. DIABETES
- Immune biomarkers in immunotherapeutic trials for type 1 diabetes: Cui prodest?
- (2012) S. Culina et al. DIABETES & METABOLISM
- Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
- (2012) V. Parikka et al. DIABETOLOGIA
- Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
- (2012) A.-G. Ziegler et al. DIABETOLOGIA
- Genetics of the HLA Region in the Prediction of Type 1 Diabetes
- (2011) Janelle A. Noble et al. Current Diabetes Reports
- Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
- (2011) Nicole Sherry et al. LANCET
- Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
- (2011) Tihamer Orban et al. LANCET
- Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
- (2010) J. B. Matthews et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function
- (2009) Mark D. Pescovitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interferon- initiates type 1 diabetes in nonobese diabetic mice
- (2008) Q. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation