Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice

Modulation of Leukocytes of the Innate Arm of the Immune System as a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes

(2021) Alessandra Petrelli et al.   DIABETES

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

(2021) Yesica Garciafigueroa et al.   Frontiers in Endocrinology

Type 1 diabetes mellitus: much progress, many opportunities

(2021) Alvin C. Powers   JOURNAL OF CLINICAL INVESTIGATION

A long-half-life, high-affinity P-selectin inhibitor

(2021) Peter L. Gross   BLOOD

Fibrin exposure triggers αIIbβ3‐independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge‐dependent manner

(2020) Samantha J. Montague et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

(2020) Theodora-Dorita Tsourouktsoglou et al.   Cell Reports

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

(2020) Lingling Shu et al.   CLINICAL SCIENCE

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice

(2020) Fernanda M.C. Sodré et al.   DIABETES

Neutralizing the pathological effects of extracellular histones with small polyanions

(2020) Connor H. O’ Meara et al.   Nature Communications

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet’s Pathway to Prevention

(2019) Emily K. Sims et al.   DIABETES CARE

Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis

(2019) Franziska Herster et al.   Frontiers in Immunology

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes

(2019) Laura A. Claessens et al.   DIABETOLOGIA

Misunderstandings Between Platelets and Neutrophils Build in Chronic Inflammation

(2019) Giuseppe A. Ramirez et al.   Frontiers in Immunology

From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders

(2018) Zuzanna Małgorzata Łukasik et al.   RHEUMATOLOGY INTERNATIONAL

Reduction in White Blood Cell, Neutrophil and Red Blood Cell counts Related to Gender, HLA and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

(2018) Falastin Salami et al.   DIABETES

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

(2018) Norma Maugeri et al.   Science Translational Medicine

Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia

(2018) Thomas A. Blair et al.   Scientific Reports

Platelet Activation and Platelet–Leukocyte Aggregates in Type I Diabetes Mellitus

(2018) Asmaa M. Zahran et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells

(2016) H. A. Mena et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of platelets in neutrophil extracellular trap (NET) production and tissue injury

(2016) Seok-Joo Kim et al.   SEMINARS IN IMMUNOLOGY

Neutrophils in type 1 diabetes

(2016) Juan Huang et al.   Journal of Diabetes Investigation

Platelets Guide Leukocytes to Their Sites of Extravasation

(2016) Gabriele Zuchtriegel et al.   PLOS BIOLOGY

Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice

(2016) Dina Silke Malling Damlund et al.   Journal of Diabetes Research

Immunodetection of NETs in Paraffin-Embedded Tissue

(2016) Volker Brinkmann et al.   Frontiers in Immunology

Islet Heparan Sulfate but Not Heparan Sulfate Proteoglycan Core Protein Is Lost During Islet Isolation and Undergoes Recovery Post-Islet Transplantation

(2015) F. J. Choong et al.   AMERICAN JOURNAL OF TRANSPLANTATION

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

Platelets in leucocyte recruitment and function

(2015) Jan Rossaint et al.   CARDIOVASCULAR RESEARCH

Chromatin

(2015) David S. Gross et al.   CURRENT BIOLOGY

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes

(2015) Clayton E. Mathews et al.   DIABETES

The Streetlight Effect in Type 1 Diabetes

(2015) Manuela Battaglia et al.   DIABETES

Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease

(2015) Mark A. Atkinson et al.   DIABETES CARE

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes

(2015) Waltraud Schrottmaier et al.   THROMBOSIS AND HAEMOSTASIS

Altered Platelets’ morphological parameters in children with type 1 diabetes – a case-control study

(2015) Beata Malachowska et al.   BMC Endocrine Disorders

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes

(2014) Y. Wang et al.   DIABETES

Islet inflammation in human type 1 diabetes mellitus

(2014) Noel G. Morgan et al.   IUBMB LIFE

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Neutrophil extracellular traps (NETs) and the role of platelets in infection

(2014) Robert Andrews et al.   THROMBOSIS AND HAEMOSTASIS

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

The diagnosis of insulitis in human type 1 diabetes

(2013) M. L. Campbell-Thompson et al.   DIABETOLOGIA

Reduced Blood Leukocyte and Neutrophil Numbers in the Pathogenesis of Type 1 Diabetes

(2013) M. Harsunen et al.   HORMONE AND METABOLIC RESEARCH

Serum proteomics reveals systemic dysregulation of innate immunity in type 1 diabetes

(2013) Qibin Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction

(2012) Elizabeth E. Gardiner et al.   BLOOD REVIEWS

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulitis in human type 1 diabetes

(2011) Peter In't Veld   Islets

Quantification and Three-Dimensional Imaging of the Insulitis-Induced Destruction of  -Cells in Murine Type 1 Diabetes

(2010) T. Alanentalo et al.   DIABETES

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concentrations of circulating P-Selectin are increased in patients with newly diagnosed insulin-dependent diabetes mellitus

(2009) H.-P. Kopp et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Nephropathy in Type 1 diabetes is associated with increased circulating activated platelets and platelet hyperreactivity

(2009) Inge Tarnow et al.   PLATELETS

Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity

(2009) Jérémie Sellam et al.   ARTHRITIS RESEARCH & THERAPY

Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation

(2008) Kevin J. Woollard et al.   CIRCULATION RESEARCH