High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways

Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue

(2022) Teia Noel et al.   Frontiers in Physiology

The study of single cells in diabetic kidney disease

(2021) Harmandeep Kaur et al.   JOURNAL OF NEPHROLOGY

Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease

(2021) Eriene-Heidi Sidhom et al.   JOURNAL OF CLINICAL INVESTIGATION

Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems

(2021) Shahar Alon et al.   SCIENCE

MUC1 Mitigates Renal Injury and Inflammation in Endotoxin Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-Inflammatory Macrophages Infiltration

(2021) Jean-Baptiste Gibier et al.   SHOCK

Modelling distal convoluted tubule (patho)physiology

(2021) Charlotte J.A. Olde Hanhof et al.   TISSUE ENGINEERING PART C-METHODS

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

(2021) Bing He et al.   Nature Communications

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

(2021) Yoshiharu Muto et al.   Nature Communications

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

(2021) Zhen Miao et al.   Nature Communications

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

(2021) Abbe R. Clark et al.   AMERICAN JOURNAL OF PATHOLOGY

Dissecting mammalian spermatogenesis using spatial transcriptomics

(2021) Haiqi Chen et al.   Cell Reports

Clinical and Genetic Spectra of Autosomal Dominant Tubulointerstitial Kidney Disease due to Mutations in UMOD and MUC1

(2020) E. Olinger et al.   KIDNEY INTERNATIONAL

TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling

(2020) Zhenbang Zhu et al.   PLoS Pathogens

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front

(2020) Christian M. Schürch et al.   CELL

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology

(2020) Antonio Saviano et al.   JOURNAL OF HEPATOLOGY

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

(2020) Lars Muhl et al.   Nature Communications

Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

(2020) José Fernández Navarro et al.   iScience

Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2

(2020) Robert R. Stickels et al.   NATURE BIOTECHNOLOGY

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies

(2020) Moran Dvela-Levitt et al.   TRENDS IN MOLECULAR MEDICINE

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway

(2019) Wenqing Tang et al.   Oncogenesis

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

(2019) Samuel G. Rodriques et al.   SCIENCE

Urinary Renin in Patients and Mice With Diabetic Kidney Disease

(2019) Jeannette Tang et al.   HYPERTENSION

Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species

(2019) Kurt A. Zimmerman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues

(2019) Jocelyn Y. Kishi et al.   NATURE METHODS

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

(2019) Moran Dvela-Levitt et al.   CELL

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

(2019) Blue B. Lake et al.   Nature Communications

Multiplexed detection of RNA using MERFISH and branched DNA amplification

(2019) Chenglong Xia et al.   Scientific Reports

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression

(2019) Chenglong Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal immune zonation of the human kidney

(2019) Benjamin J. Stewart et al.   SCIENCE

Autosomal dominant tubulointerstitial kidney disease

(2019) Olivier Devuyst et al.   Nature Reviews Disease Primers

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

(2019) Andrew Ransick et al.   DEVELOPMENTAL CELL

Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics

(2019) Konstantin Carlberg et al.   Scientific Reports

Acute Kidney Injury and Progression of Diabetic Kidney Disease

(2018) Samuel Mon-Wei Yu et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

A Review of Podocyte Biology

(2018) Puneet Garg   AMERICAN JOURNAL OF NEPHROLOGY

Third-generationin situhybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust

(2018) Harry M. T. Choi et al.   DEVELOPMENT

Update of pathophysiology and management of diabetic kidney disease

(2018) Yi-Chih Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

(2018) Matthew D. Young et al.   SCIENCE

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing

(2017) Ed Lein et al.   SCIENCE

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

Gender-specific differences in diabetic neuropathy in BTBR ob/ob mice

(2016) Phillipe D. O’Brien et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

ISCHEMIA in chronic kidney disease: improving the representation of patients with chronic kidney disease in cardiovascular trials

(2016) Christina M. Wyatt et al.   KIDNEY INTERNATIONAL

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses

(2015) Phillipe D. O'Brien et al.   NEUROBIOLOGY OF DISEASE

NK Cells Induce Apoptosis in Tubular Epithelial Cells and Contribute to Renal Ischemia-Reperfusion Injury

(2014) Z.-X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Podocyte Dedifferentiation: A Specialized Process for a Specialized Cell

(2014) Carl James May et al.   Frontiers in Endocrinology

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Pathophysiology of ischemic acute kidney injury

(2011) Asif A. Sharfuddin et al.   Nature Reviews Nephrology

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

(2010) K. L. Hudkins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Signaling in Regulation of Podocyte Phenotypes

(2009) Peter Y. Chuang et al.   NEPHRON PHYSIOLOGY

Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice

(2007) H. Yokoi et al.   KIDNEY INTERNATIONAL