A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complete functional characterization of disease-associated genetic variants in the complement factor H gene

(2018) Héctor Martín Merinero et al.   KIDNEY INTERNATIONAL

Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

(2018) Alexander B. Rosenberg et al.   SCIENCE

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

(2018) Chengxiang Qiu et al.   NATURE MEDICINE

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

(2018) Matthew D. Young et al.   SCIENCE

Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria

(2018) Erika B. Rangel et al.   Scientific Reports

Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in Chronic Kidney Disease

(2018) Arjun D. Sinha et al.   Clinical Journal of the American Society of Nephrology

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

(2018) Trygve E. Bakken et al.   PLoS One

Visualizing and Interpreting Single-Cell Gene Expression Datasets with Similarity Weighted Nonnegative Embedding

(2018) Yan Wu et al.   Cell Systems

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

(2017) Blue B Lake et al.   NATURE BIOTECHNOLOGY

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq

(2017) Lihe Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A haplotype in CFH family genes confers high risk of rare glomerular nephropathies

(2017) Yin Ding et al.   Scientific Reports

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA

(2017) Blue B. Lake et al.   Scientific Reports

US Renal Data System 2015 Annual Data Report: Epidemiology of Kidney Disease in the United States

(2016) Rajiv Saran et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

(2016) Biola M. Javierre et al.   CELL

Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis

(2016) Jean Fan et al.   NATURE METHODS

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Nuclear RNA-seq of single neurons reveals molecular signatures of activation

(2016) Benjamin Lacar et al.   Nature Communications

The Role of Pendrin in Renal Physiology

(2015) Susan M. Wall et al.   Annual Review of Physiology

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes

(2015) J. W. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Distal Convoluted Tubule

(2014) A. R. Subramanya et al.   Clinical Journal of the American Society of Nephrology

Complement factor H gene associations with end-stage kidney disease in African Americans

(2014) Jason A. Bonomo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Calcitonin Gene-Related Peptide: Physiology and Pathophysiology

(2014) F. A. Russell et al.   PHYSIOLOGICAL REVIEWS

Integrins in Kidney Disease

(2013) A. Pozzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Medical Costs of CKD in the Medicare Population

(2013) A. A. Honeycutt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RNA-sequencing from single nuclei

(2013) R. V. Grindberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice

(2012) M. Hoshi et al.   DEVELOPMENT

Heterozygosity for Fibrinogen Results in Efficient Resolution of Kidney Ischemia Reperfusion Injury

(2012) Amrendra Kumar Ajay et al.   PLoS One

Human nephron number: implications for health and disease

(2011) John F. Bertram et al.   PEDIATRIC NEPHROLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Experimental ischemia–reperfusion: biases and myths—the proximal vs. distal hypoxic tubular injury debate revisited

(2009) Samuel N. Heyman et al.   KIDNEY INTERNATIONAL

What do we know about chronic renal failure in young adults? II. Adult outcome of pediatric renal disease

(2009) Guy H. Neild   PEDIATRIC NEPHROLOGY