Review
Biochemistry & Molecular Biology
Eun Jin Sun, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane, Lionel Hebbard
Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.
Article
Biochemistry & Molecular Biology
Yanwei Lu, Xudong Li, Hongli Liu, Jun Xue, Zhen Zeng, Xiaorong Dong, Tao Zhang, Gang Wu, Kunyu Yang, Shuangbing Xu
Summary: LZTS2 is downregulated in HCC and associated with poor prognosis. It inhibits HCC tumorigenesis and metastasis by suppressing PI3K/AKT signaling. Furthermore, LZTS2 is targeted for degradation by E3 ligase and protein kinase, promoting HCC progression and metastasis.
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockiam
Summary: Hepatocellular carcinoma (HCC) is the third leading malignancy worldwide, causing high mortality in adults and children. This study explored the expression and function of the miR-221/AEG-1 axis in HCC. The silencing of the miR-221/AEG-1 axis induced apoptosis and G2/M phase arrest, inhibited cellular proliferation and angiogenesis in HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Article
Medicine, Research & Experimental
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang
Summary: CD58 is upregulated in HCC tissues and its overexpression is associated with poor prognosis in HCC patients. CD58 promotes proliferation and metastasis in HCC cells by activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 may serve as a prognostic biomarker and therapeutic target for HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Matteo Brindisi, Luca Frattaruolo, Raffaella Mancuso, Antonio Palumbo Piccionello, Ida Ziccarelli, Marco Catto, Orazio Nicolotti, Cosimo D. Altomare, Bartolo Gabriele, Anna Rita Cappello
Summary: Six newly synthesized alkyl (Z)-2-(2-oxopyrrolidin-3-ylidene)acetates were evaluated for their potential cytotoxic and anticancer effects, with the most lipophilic derivatives showing cytotoxicity against various breast cancer cell lines. In-depth mechanistic studies suggested that these derivatives may interfere with key enzymes in the PI3K/AKT signaling pathway, which could be a potential target for cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuan Wu, Yuhong Luo, Shan Wang, Yueying Li, Meiyu Bao, Yuanjiang Shang, Lei Chen, Weiwei Liu
Summary: This study demonstrates the protective role of AKAP12 in acute liver injury and chronic liver fibrosis, at least partially through inhibition of the PI3K/AKT/PCSK6 pathway. These findings provide a new potential treatment for liver injury and have important clinical implications.
Article
Biochemistry & Molecular Biology
Minjuan Wang, Chengliang Li, Wei Shi
Summary: FAM84B has been identified as an oncoprotein in various cancers, and its overexpression in glioma is associated with low patient survival rates. Silencing FAM84B inhibits proliferation and invasion, induces apoptosis in glioma cells, and reduces phosphorylated Akt, GSK-3 beta, and active beta-catenin levels. Inhibition of Akt blocks the promotion effects of FAM84B on the Wnt/beta-catenin pathway. Additionally, in vivo experiments show that silencing FAM84B significantly suppresses the tumorigenicity of glioma cells.
Article
Medicine, Research & Experimental
Yifu Hou, Kai Chen, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: In this study, the authors demonstrate that the long noncoding RNA LINC01419 enhances the methylation of the ZIC1 promoter, suppresses ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby promoting the malignant characteristics of hepatocellular carcinoma cells in vitro and facilitating tumor formation and metastasis.
LABORATORY INVESTIGATION
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Biochemistry & Molecular Biology
Wen-Ting Yang, Mei Chen, Rui Xu, Peng-Sheng Zheng
Summary: PRDM4 inhibits cell proliferation and tumorigenesis in cervical cancer by regulating cell cycle progression and the activity of the PI3K/AKT signaling pathway.
Article
Pharmacology & Pharmacy
Xingxing Hu, Menglin Zou, Lan Ni, Mingyang Zhang, Weishuai Zheng, Bing Liu, Zhenshun Cheng
Summary: DEC1 plays a significant role in pulmonary fibrosis by promoting epithelial-mesenchymal transition (EMT) through the PI3K/AKT/GSK-3 beta/beta-catenin integrated signaling pathway, leading to the accumulation of fibroblasts and myofibroblasts and excessive collagen deposition. Targeting DEC1 may be a potential novel therapeutic approach for idiopathic pulmonary fibrosis (IPF).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yijiao Ning, Chaoqun Deng, Chunhong Li, Weiyan Peng, Chun Yan, Jing Ran, Weihong Chen, Yujia Liu, Jiuyi Xia, Lin Ye, Zhengqiang Wei, Tingxiu Xiang
Summary: PCDH20 expression is attenuated in esophageal cancer, possibly due to promoter methylation. PCDH20 exerts anti-tumor effects through MAP3K9 downregulation and inhibition of AKT/β-catenin signaling in ESCC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Anatomy & Morphology
Li Zhang, Shuai Chang, Yao Zhao, Gang Cao, Di Zhang
Summary: Hepatocellular carcinoma (HCC) is a prevalent liver cancer type with high mortality. The decreased expression of miR-4317 in HCC inhibits cancer progression by targeting ZNF436, suggesting miR-4317 as a potential prognostic biomarker and therapeutic target for HCC.
Article
Biochemistry & Molecular Biology
Yu Cai, Guanqun Huang, Lijie Ma, Ling Dong, She Chen, Xizhong Shen, Shuncai Zhang, Ruyi Xue, Deqiang Sun, Si Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Cell Biology
Shanhu Qian, Yixiang Han, Yifen Shi, Wanling Xu, Yiyi Zhu, Songfu Jiang, Yi Chen, Zhijie Yu, Si Zhang, Yiping Yang, Kang Yu, Shenghui Zhang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Immunology
Rongyi Chen, Ying Sun, Xiaomeng Cui, Zongfei Ji, Xiufang Kong, Sifan Wu, Qingrong Huang, Xiaoming Dai, Si Zhang, Lili Ma, Lindi Jiang
JOURNAL OF AUTOIMMUNITY
(2019)
Article
Biochemistry & Molecular Biology
Guang-Xi Zhao, Ying-Ying Xu, Shu-Qiang Weng, Si Zhang, Ying Chen, Xi-Zhong Shen, Ling Dong, She Chen
Article
Biochemistry & Molecular Biology
Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Ling Dong, Harry L. A. Janssen, Si Zhang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Oncology
Bingrui Wu, Dalong Sun, Lijie Ma, Yiran Deng, Si Zhang, Ling Dong, She Chen
Article
Multidisciplinary Sciences
Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Longzi Liu, Ling Dong, Si Zhang
Article
Gastroenterology & Hepatology
Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L. A. Janssen, Ling Dong, Si Zhang, She Chen
JOURNAL OF HEPATOLOGY
(2020)
Article
Oncology
Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xiao-Xiao Wang, Si Zhang, Ping-Ping Dong, Yao-Hua Li, Li Zhang, Song-Hai Shi, Zhi-Qiang Yu, She Chen
Summary: Dasm1 regulates dendrite arborization and spine formation by activating MRCK beta, leading to intracellular signaling communication and actin rearrangement, to control neuronal development in the mammalian brain.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jinglei Li, Hanxing Tong, Dongping Li, Qiuyu Jiang, Yong Zhang, Wenqing Tang, Dayong Jin, She Chen, Xinyu Qin, Si Zhang, Ruyi Xue
Summary: This study demonstrates that DKFZp434J0226 regulates alternative splicing through phosphorylation of SF3B6 in PDAC, leading to an oncogenic phenotype in PDAC.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yaohua Li, Yiran Deng, Yannan Zhao, Wei Zhang, Si Zhang, Li Zhang, Biyun Wang, Yingying Xu, She Chen
Summary: This study identified a novel p53 target gene, IGSF9, which is down-regulated in breast cancer tissues. Loss of IGSF9 is associated with frequent metastasis and poor prognosis. Wild-type p53 activates IGSF9 to inhibit breast cancer cell migration and invasion.
Article
Cardiac & Cardiovascular Systems
Huajie Xu, Jiaojiao Zheng, Xin Zhao, Qi Zhou, Bing Fan, Hongyi Wu, Si Zhang, Junbo Ge
Summary: This study found no evidence of an increased risk of ischemic or bleeding events after vaccination with inactivated SARS-CoV-2 vaccine among Chinese patients with CAD, although the statistical power was limited.
CARDIOVASCULAR RESEARCH
(2023)
Article
Rheumatology
X. Kong, L. Ma, Z. Ji, Z. Dong, Z. Zhang, J. Hou, S. Zhang, L. Ma, L. Jiang
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2018)