Roles of Selenoproteins in Brain Function and the Potential Mechanism of Selenium in Alzheimer’s Disease

Selenium restores synaptic deficits by modulating NMDA receptors and selenoprotein K in an Alzheimer’s disease model

(2020) Zhonghao Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase-1 Knockout Facilitates Memory Impairment Induced by β-Amyloid (1–42) in Mice via Inhibition of PKC βII-Mediated ERK Signaling; Application with Glutathione Peroxidase-1 Gene-Encoded Adenovirus Vector

(2020) Eun-Joo Shin et al.   NEUROCHEMICAL RESEARCH

His-Rich Domain of Selenoprotein P Ameliorates Neuropathology and Cognitive Deficits by Regulating TrkB Pathway and Zinc Homeostasis in an Alzheimer Model of Mice

(2020) Caiping Yue et al.   ACS Chemical Neuroscience

Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R

(2019) Xue-Lian Meng et al.   NEUROSCIENCE

Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer

(2019) Michael P. Marciel et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selenoprotein P and its potential role in Alzheimer’s disease

(2019) Nikolay Solovyev   Hormones-International Journal of Endocrinology and Metabolism

Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson’s disease

(2019) Xiong Zhang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Selenoprotein T Promotes Proliferation and G1-to-S Transition in SK-N-SH Cells: Implications in Parkinson's Disease

(2019) Zi-Qiang Shao et al.   JOURNAL OF NUTRITION

Loss of MsrB1 perturbs spatial learning and long-term potentiation/long-term depression in mice

(2019) Tengrui Shi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Blocking the Thiol at Cysteine-322 Destabilizes Tau Protein and Prevents Its Oligomer Formation

(2018) Hui Chen et al.   ACS Chemical Neuroscience

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis

(2018) Matthew W. Pitts et al.   CELL CALCIUM

Catechol-O-methyltransferase, Cognition and Alzheimer's Disease

(2018) Matea Nikolac Perkovic et al.   Current Alzheimer Research

Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

(2018) Nikolay Solovyev et al.   FREE RADICAL BIOLOGY AND MEDICINE

EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans

(2018) Yasuhiro Horibata et al.   JOURNAL OF LIPID RESEARCH

Selenium-enriched yeast inhibited β-amyloid production and modulated autophagy in a triple transgenic mouse model of Alzheimer’s Disease

(2018) Guoli Song et al.   Metallomics

Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice

(2018) Yongli Xie et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Association of GPX1 and GPX4 polymorphisms with episodic memory and Alzheimer’s disease

(2018) Tatiane Jacobsen da Rocha et al.   NEUROSCIENCE LETTERS

Comparison of the effects of selenomethionine and selenium-enriched yeast in the triple-transgenic mouse model of Alzheimer's disease

(2018) Zhong-Hao Zhang et al.   Food & Function

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Glutathione peroxidase-1 overexpressing transgenic mice are protected from neurotoxicity induced by microcystin-leucine-arginine

(2018) Eun-Joo Shin et al.   ENVIRONMENTAL TOXICOLOGY

Selenomethionine Ameliorates Cognitive Decline, Reduces Tau Hyperphosphorylation, and Reverses Synaptic Deficit in the Triple Transgenic Mouse Model of Alzheimer's Disease

(2018) Guoli Song et al.   JOURNAL OF ALZHEIMERS DISEASE

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

(2018) Jia-rui Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain

(2018) Sungro Jo et al.   JOURNAL OF CLINICAL INVESTIGATION

Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease

(2017) Na Jin et al.   EXPERIMENTAL NEUROLOGY

Long-Term Dietary Supplementation with Selenium-Enriched Yeast Improves Cognitive Impairment, Reverses Synaptic Deficits, and Mitigates Tau Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease

(2017) Zhong-Hao Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

(2017) Yan Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenomethionine Attenuates the Amyloid-β Level by Both Inhibiting Amyloid-β Production and Modulating Autophagy in Neuron-2a/AβPPswe Cells

(2017) Zhong-Hao Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer’s disease mice

(2017) Yongli Xie et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

(2017) Zhong-Hao Zhang et al.   JOURNAL OF NEUROSCIENCE

Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

(2017) Annalisa Nobili et al.   Nature Communications

Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE)

(2017) Richard J. Kryscio et al.   JAMA Neurology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Association of Selenoprotein P with Alzheimer's Pathology in Human Cortex

(2017) Frederick P. Bellinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease

(2016) Loubna Boukhzar et al.   ANTIOXIDANTS & REDOX SIGNALING

Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly

(2016) Dario Tejera et al.   Current Alzheimer Research

Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response

(2016) Yongzhong Zhao et al.   FEBS LETTERS

Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology

(2016) Rachel H.L.H. Rueli et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenomethionine reduces the deposition of beta-amyloid plaques by modulating β-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease

(2016) Zhong-Hao Zhang et al.   Metallomics

The Protective Role of Selenium on Scopolamine-Induced Memory Impairment, Oxidative Stress, and Apoptosis in Aged Rats: The Involvement of TRPM2 and TRPV1 Channels

(2016) Hasan Balaban et al.   MOLECULAR NEUROBIOLOGY

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Dietary Selenium and Human Health

(2016) Lutz Schomburg   Nutrients

Selenoprotein W redox-regulated Ca2+ channels correlate with selenium deficiency-induced muscles Ca2+ leak

(2016) Haidong Yao et al.   Oncotarget

Selenoprotein K and Protein Palmitoylation

(2015) Gregory J. Fredericks et al.   ANTIOXIDANTS & REDOX SIGNALING

Update on Selenoprotein Biosynthesis

(2015) Anne-Laure Bulteau et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation

(2015) Jea Hwang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling

(2015) Nikolay D. Solovyev   JOURNAL OF INORGANIC BIOCHEMISTRY

Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease

(2015) M. W. Pitts et al.   JOURNAL OF NEUROSCIENCE

Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice

(2015) Matthieu T. Castex et al.   MOLECULAR NEUROBIOLOGY

Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine

(2015) Anton A. Turanov et al.   PLoS One

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein

(2014) Yeong Ha Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibitory Act of Selenoprotein P on Cu+/Cu2+-Induced Tau Aggregation and Neurotoxicity

(2014) Xiubo Du et al.   INORGANIC CHEMISTRY

Direct Interaction between Selenoprotein P and Tubulin

(2014) Xiubo Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

(2014) Gregory J. Fredericks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intersection of selenoproteins and kinase signalling

(2013) Anna Lenart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Different Forms of Selenoprotein M Differentially Affect Aβ Aggregation and ROS Generation

(2013) Ping Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity

(2013) Xiubo Du et al.   Metallomics

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Turnover of C99 is Controlled by a Crosstalk between ERAD and Ubiquitin-Independent Lysosomal Degradation in Human Neuroglioma Cells

(2013) Hianara A. Bustamante et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenoprotein W expression and regulation in mouse brain and neurons

(2013) Arjun V. Raman et al.   Brain and Behavior

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Glutathione Peroxidase 1 Pro198Leu Polymorphism in Brazilian Alzheimer’s Disease Patients: Relations to the Enzyme Activity and to Selenium Status

(2012) Bárbara Rita Cardoso et al.   Journal of Nutrigenetics and Nutrigenomics

The synergistic effect of beta-boswellic acid and Nurr1 overexpression on dopaminergic programming of antioxidant glutathione peroxidase-1-expressing murine embryonic stem cells

(2012) M. Abasi et al.   NEUROSCIENCE

Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating

(2012) M.W. Pitts et al.   NEUROSCIENCE

Selenoprotein S expression in reactive astrocytes following brain injury

(2011) Noelia Fradejas et al.   GLIA

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

(2011) S. Verma et al.   JOURNAL OF IMMUNOLOGY

Synergy Between Glutathione Peroxidase-1 and Astrocytic Growth Factors Suppresses Free Radical Generation and Protects Dopaminergic Neurons against 6-Hydroxydopamine

(2011) Mossa Gardaneh et al.   REJUVENATION RESEARCH

Genetic Polymorphisms in Apolipoprotein E and Glutathione Peroxidase 1 Genes in the Ecuadorian Population Affected With Alzheimer’s Disease

(2010) César Paz-y-Miño et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Type 3 Deiodinase, a Thyroid-Hormone-Inactivating Enzyme, Controls Survival and Maturation of Cone Photoreceptors

(2010) L. Ng et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Neuroprotective Functions of Selenoprotein M and its Role in Cytosolic Calcium Regulation

(2009) Mariclair A. Reeves et al.   ANTIOXIDANTS & REDOX SIGNALING

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

(2009) Tauheed Ishrat et al.   BRAIN RESEARCH

Nutritional status of selenium in Alzheimer's disease patients

(2009) Bárbara Rita Cardoso et al.   BRITISH JOURNAL OF NUTRITION

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M

(2009) Hwang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death

(2009) Youn Wook Chung et al.   MOLECULES AND CELLS

Selenium attenuates Aβ production and Aβ-induced neuronal death

(2009) A-Ryeong Gwon et al.   NEUROSCIENCE LETTERS

Dopamine Controls Persistence of Long-Term Memory Storage

(2009) J. I. Rossato et al.   SCIENCE

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination inSepp-knockout mice

(2008) Kostja Renko et al.   BIOCHEMICAL JOURNAL

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function

(2008) Lily Ng et al.   ENDOCRINOLOGY

Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion

(2008) Luca Grumolato et al.   FASEB JOURNAL

Lipid peroxidation up-regulates BACE1 expressionin vivo: a possible early event of amyloidogenesis in Alzheimer’s disease

(2008) Liuji Chen et al.   JOURNAL OF NEUROCHEMISTRY

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

The Role of Thioredoxin Reductases in Brain Development

(2008) Jonna Soerensen et al.   PLoS One