A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors

(2021) Zhibing Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

(2021) Peter C. Ray et al.   ACS Omega

The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition

(2021) Hui Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake

(2021) Jeyun Jo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib

(2021) Chao Wan et al.   JOURNAL OF ORGANIC CHEMISTRY

DMAP Catalyzed Domino Rauhut–Currier Cyclization Reaction between Alkylidene Pyrazolones and Nitro-olefins: Access to Tetrahydropyrano[2,3-c]pyrazoles

(2021) Nimisha Bania et al.   JOURNAL OF ORGANIC CHEMISTRY

Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as antioxidant agents

(2021) Azza A. El-Badawy et al.   Journal of Sulfur Chemistry

New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study

(2021) Islam H. El Azab et al.   MOLECULES

A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles

(2021) Huahong Chen et al.   TETRAHEDRON

Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

(2021) Curt A. Dvorak et al.   TETRAHEDRON LETTERS

A cascade reaction of cinnamyl azides with vinyl sulfones directly generates dihydro-pyrrolo-pyrazole heterocycles

(2021) Angela S. Carlson et al.   TETRAHEDRON LETTERS

A New Approach for the Synthesis and Biological Activities of Novel Thiazolyl‐Pyrazole Derivatives

(2021) Ghada S. Masaret   ChemistrySelect

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

(2021) Bhautikkumar Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization, reaction mechanism prediction and biological study of mono, bis and tetrakis pyrazole derivatives against Fusarium oxysporum f. sp. Albedinis with conceptual DFT and ligand-protein docking studies

(2021) Yassine Kaddouri et al.   BIOORGANIC CHEMISTRY

Antiproliferative Properties and Structural Analysis of Newly Synthesized Schiff Bases Bearing Pyrazole Derivatives and Molecular Docking Studies

(2021) Nesrin Şener et al.   JOURNAL OF MOLECULAR STRUCTURE

Reactivity of Cross-Conjugated Enynones in Cyclocondensations with Hydrazines: Synthesis of Pyrazoles and Pyrazolines

(2021) Alexander A. Golovanov et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti-Mycobacterium tuberculosis H37Ra Compounds

(2021) Kok Tong Wong et al.   MOLECULES

Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism

(2021) Yunyun Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors

(2021) Haiyan Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-α inhibitory activity

(2021) Somaia S. Abd El-Karim et al.   BIOORGANIC CHEMISTRY

Synthesis, DFT calculation, pharmacological evaluation, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives

(2021) Mostafa M.K. Amer et al.   BIOORGANIC CHEMISTRY

Discovery of 1,3,4,5-tetrasubstituted pyrazoles as anti-trypanosomatid agents: Identification of alterations in flagellar structure of L. amazonensis

(2021) Michael J.V. da Silva et al.   BIOORGANIC CHEMISTRY

4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents

(2021) Raj KC. Hansa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Flexible Synthesis and Herbicidal Activity of Fully Substituted 3‐Hydroxypyrazoles

(2021) Neil R. Judge et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery of Novel Pyrazole Carboxylate Derivatives Containing Thiazole as Potential Fungicides

(2021) Dongguo Xia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure–Activity Relationship, and Molecular Docking

(2021) Xiaobin Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis, insecticidal activities, and structure–activity relationships of 1,3,4‐oxadiazole‐ring‐containing pyridylpyrazole‐4‐carboxamides as novel insecticides of the anthranilic diamide family

(2021) Abdalla Khallaf et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Urea derivatives of piperazine doped with pyrazole‐4‐carboxylic acids: Synthesis and antimicrobial evaluation

(2021) Harshita Phougat et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

A facile one-pot, three-component synthesis of a new series of thiazolyl pyrazole carbaldehydes: In vitro anticancer evaluation, in silico ADME/T, and molecular docking studies

(2021) Srikanth Mamidala et al.   JOURNAL OF MOLECULAR STRUCTURE

Assessment of anti-hemolytic, cytotoxicity, antioxidant activities and molecular docking study based on thienopyrazole scaffold as pharmacophore

(2021) Mohamed A. El-Borai et al.   JOURNAL OF MOLECULAR STRUCTURE

Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity

(2021) Svetlana A. Popova et al.   MOLECULES

Phosphine-Catalyzed Cascade Annulation of MBH Carbonates and Diazenes: Synthesis of Hexahydrocyclopenta[c]pyrazole Derivatives

(2021) Hongxiang Li et al.   ORGANIC LETTERS

Copper(II) Anchored on Amine-Functionalized MMT: A Highly Efficient Catalytic System for the One-Pot Synthesis of Bispyrano[2,3-c]pyrazole Derivatives

(2021) Majid Ahmadzadeh et al.   Journal of Chemistry

Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles

(2021) Karthik Kumara et al.   Heliyon

CuO-NPs/TFA: a New Catalytic System to Synthesize a Novel Series of Pyrazole Imines with High Antioxidant Properties

(2021) Hanan Mohamed Fathy Elnagdy et al.   BioNanoScience

Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects

(2021) O.M. Hendawy et al.   BIOORGANIC CHEMISTRY

Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)

(2021) Esraa Z. Mohammed et al.   BIOORGANIC CHEMISTRY

Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA

(2021) Seham A. Ibrahim et al.   BIOORGANIC CHEMISTRY

Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds

(2021) Elva Morretta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, anticancer activity and molecular docking analysis of novel dinitrophenylpyrazole bearing 1,2,3-triazoles

(2021) Kotyada Suryanarayana et al.   JOURNAL OF MOLECULAR STRUCTURE

[MerDABCO-SO3H]Cl catalyzed synthesis, antimicrobial and antioxidant evaluation and molecular docking study of pyrazolopyranopyrimidines

(2021) Pradeep Patil et al.   JOURNAL OF MOLECULAR STRUCTURE

Microwave-assisted synthesis of pyrano[2,3-c]-pyrazole derivatives and their anti-microbial, anti-malarial, anti-tubercular, and anti-cancer activities

(2021) Paranjay H. Parikh et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, crystal structure, DFT, α-glucosidase and α-amylase inhibition and molecular docking studies of (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide

(2021) Khalid Karrouchi et al.   JOURNAL OF MOLECULAR STRUCTURE

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways

(2021) Maria Grazia Signorello et al.   MOLECULES

Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based approach

(2021) Saman Taj et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Conventional and Microwave-Assisted Synthesis, Antitubercular Activity, and Molecular Docking Studies of Pyrazole and Oxadiazole Hybrids

(2021) Nisheeth C. Desai et al.   ACS Omega

Pyrazole-Based Water-Soluble Dendrimer Nanoparticles as a Potential New Agent against Staphylococci

(2021) Silvana Alfei et al.   Biomedicines

Synthesis, anti-tubercular evaluation and molecular docking studies of Nitrogen-rich piperazine-pyrimidine-pyrazole Hybrid Motifs

(2021) Bhavinkumar Vavaiya et al.   Current Chemistry Letters

Synthesis and in vitro investigation of novel cytotoxic pyrimidine and pyrazolopyrimidne derivatives showing apoptotic effect

(2020) Fatma A. Ragab et al.   BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors

(2020) Ehab M. Gedawy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial evaluation and molecular docking studies of pyrazole–thiosemicarbazones and their pyrazole–thiazolidinone conjugates

(2020) Oluwakemi Ebenezer et al.   MOLECULAR DIVERSITY

Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene

(2020) Chuanle Zhu et al.   ORGANIC LETTERS

Synthesis of a structure containing three N-fused heterocycles with very high bond-forming through a one-pot reaction

(2020) Meysam Alizadeh-Kouzehrash et al.   TETRAHEDRON

Synthesis of Fused Indolo‐Pyrazoles and Their Antimicrobial and Insecticidal Activities against Anopheles arabiensis Mosquito

(2020) Talent R. Makhanya et al.   ChemistrySelect

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies

(2020) Wael A.A. Fadaly et al.   BIOORGANIC CHEMISTRY

Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase

(2020) Dina H. Dawood et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II

(2020) Yali Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, evaluation, molecular dynamics simulation and targets identification of novel pyrazole-containing imide derivatives

(2020) Wenxi Cai et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

New fused pyrazolopyrimidine derivatives; heterocyclic styling, synthesis, molecular docking and anticancer evaluation

(2020) A.Y. Hassan et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Conventional and microwave reactions of 1,3‐diaryl‐5,4‐enaminonitrile‐pyrazole derivative with expected antimicrobial and anticancer activities

(2020) Kurls E. Anwer et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Catalyst‐free green synthesis and study of antioxidant activity of new pyrazole derivatives

(2020) Navisa Tabarsaei et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Green synthesis and antifungal activities of novel 3‐(trifluoromethyl)‐4, 5‐dihydro‐1 H ‐furo[2,3‐ c ]pyrazole derivatives

(2020) Fangshun Tan et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, X-ray structure, vibrational spectroscopy, DFT, biological evaluation and molecular docking studies of (E)-N'-(4-(dimethylamino)benzylidene)-5-methyl-1H-pyrazole-3-carbohydrazide

(2020) Khalid Karrouchi et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis of Coumarin‐Analogues: Analytical, Spectral, Conformational, MOE‐Docking and Antimicrobial Studies

(2020) Abrar Bayazeed et al.   ChemistrySelect

Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies

(2020) Ramar Sivaramakarthikeyan et al.   ACS Omega

New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics

(2020) John N. Philoppes et al.   BIOORGANIC CHEMISTRY

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase

(2020) Hao Liu et al.   BIOORGANIC CHEMISTRY

Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles

(2020) Daniela Hartwig de Oliveira et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Design, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole–Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors

(2020) Bin Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Collaborative Activation of Trifluoroacetyl Diazoester by a Lewis Acid and Base for the Synthesis of Polysubstituted 4-Trifluoromethylpyrazoles

(2020) Zheng Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis, in silico studies, and evaluation of novel chalcones and their pyrazoline derivatives for antibacterial and antitubercular activities

(2020) Shivani Pola et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of pyrazole-4-carboxamides as potential fungicide candidates

(2020) Cuntao Dong et al.   MOLECULAR DIVERSITY

Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities

(2020) Afzal B. Shaik et al.   MOLECULES

Synthesis of some new functionalized pyrano[2,3-c]pyrazoles and pyrazolo[4′,3′:5,6] pyrano[2,3-d]pyrimidines bearing a chromone ring as antioxidant agents

(2020) Tarik E. Ali et al.   SYNTHETIC COMMUNICATIONS

Novel pyrazole‐clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti‐inflammatory agents

(2020) Soukhyarani G. Nayak et al.   ARCHIV DER PHARMAZIE

Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors

(2020) Wasim Akhtar et al.   ARCHIV DER PHARMAZIE

Attacking the mitochondria of colorectal carcinoma by novel 2-cyanoacrylamides linked to ethyl 1,3-diphenylpyrazole-4-carboxylates moiety as a new trend for chemotherapy

(2020) Magda F. Mohamed et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Mechanism of Action of Novel Pyrazole Carboxamide Containing a Diarylamine Scaffold against Rhizoctonia solani

(2020) Yongtian Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gold(I)-Catalyzed Reactions between 2-(1-Alkynyl)-2-alken-1-ones and Vinyldiazo Ketones for Divergent Synthesis of Nonsymmetric Heteroaryl-Substituted Triarylmethanes: N- versus C-Attack Paths

(2020) Rahul Dadabhau Kardile et al.   ORGANIC LETTERS

Copper-Catalyzed Aerobic Cyclization of β,γ-Unsaturated Hydrazones with Concomitant C═C Bond Cleavage

(2020) Zhenwei Fan et al.   ORGANIC LETTERS

Design, Synthesis and Biological Evaluation of Novel Furan & Thiophene Containing Pyrazolyl Pyrazolines as Antimalarial Agents

(2020) Hemantkumar N. Akolkar et al.   POLYCYCLIC AROMATIC COMPOUNDS

Synthesis and biological evaluation of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidines as potent antidiabetic, anticancer and antioxidant agents

(2020) Vinay Pogaku et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

(2020) Jeniffer do Nascimento Ascencio Camargo et al.   Frontiers in Pharmacology

New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies

(2020) Khaled R. A. Abdellatif et al.   ARCHIV DER PHARMAZIE

Sulfamic acid catalyzed synthesis of new 3,5-[(sub)phenyl]-1H-pyrazole bearing N1-isonicotinoyl: And their pharmacological activity evaluation

(2020) Jayashri D. Bhirud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Celebrex derivatives: Synthesis, α-glucosidase inhibition, crystal structures and molecular docking studies

(2020) Nabeela Kausar et al.   BIOORGANIC CHEMISTRY

Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors

(2020) Jian Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation

(2020) Yanina V. Burgart et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expedient Discovery for Novel Antifungal Leads Targeting Succinate Dehydrogenase: Pyrazole-4-formylhydrazide Derivatives Bearing a Diphenyl Ether Fragment

(2020) Xiaobin Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In silico study, synthesis, and evaluation of the antimalarial activity of hybrid dimethoxy pyrazole 1,3,5‐triazine derivatives

(2020) Pinku Gogoi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Synthesis, biological evaluation, and molecular docking studies of novel pyrazole, pyrazoline‐clubbed pyridine as potential antimicrobial agents

(2020) Nisheeth C. Desai et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of New Thiazole and Pyrazole Clubbed 1,2,3-Triazol Derivatives as Potential Antimycobacterial and Antibacterial Agents

(2020) Shivaji M. Jagadale et al.   POLYCYCLIC AROMATIC COMPOUNDS

Synthesis, characterization, crystal structure, Hirshfeld surface analysis, antioxidant properties and DFT calculations of a novel pyrazole derivative: Ethyl 1-(2,4-dimethylphenyl)-3-methyl-5-phenyl-1H-pyrazole-4-carboxylate

(2020) S. Naveen et al.   JOURNAL OF MOLECULAR STRUCTURE

Hydroxyl Alkyl Ammonium Ionic liquid assisted Green and One-pot regioselective access to Functionalized Pyrazolodihydropyridine core and their pharmacological evaluation

(2019) Divyang M. Patel et al.   BIOORGANIC CHEMISTRY

COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core

(2019) Eman K.A. Abdelall et al.   BIOORGANIC CHEMISTRY

Identification of Pyrazolo[1,5-a]pyridine-3-carboxamide Diaryl Derivatives as Drug Resistant Antituberculosis Agents

(2019) Xianglong Hu et al.   ACS Medicinal Chemistry Letters

Ketene dithioacetal mediated synthesis of 1,3,4,5-tetrasubstituted pyrazole derivatives and their biological evaluation

(2019) Pravin S. Bhale et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Domino C-H Sulfonylation and Pyrazole Annulation for Fully Substituted Pyrazole Synthesis in Water Using Hydrophilic Enaminones

(2019) Yanhui Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model

(2019) Jing Bo Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based design, synthesis and biological evaluation of a newer series of pyrazolo[1,5-a]pyrimidine analogues as potential anti-tubercular agents

(2019) Palmi Modi et al.   BIOORGANIC CHEMISTRY

Thiazolyl-pyrazole derivatives as potential antimycobacterial agents

(2019) Sushma J. Takate et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ligand based design and synthesis of pyrazole based derivatives as selective COX-2 inhibitors

(2019) Manikanta Murahari et al.   BIOORGANIC CHEMISTRY

Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations

(2019) P. Thangarasu et al.   BIOORGANIC CHEMISTRY

Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies

(2019) Mai S. El-Shoukrofy et al.   BIOORGANIC CHEMISTRY

New pyrazolyl-dibenzo[b,e][1,4]diazepinones: room temperature one-pot synthesis and biological evaluation

(2019) Gaurangkumar C. Brahmbhatt et al.   MOLECULAR DIVERSITY

Ultrasonication-ionic liquid synergy for the synthesis of new potent anti-tuberculosis 1,2,4-triazol-1-yl-pyrazole based spirooxindolopyrrolizidines

(2019) Vinay Pogaku et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents

(2019) Mohemmed Faraz Khan et al.   BIOORGANIC CHEMISTRY

Synthesis of 3-indolylmethyl substituted (pyrazolo / benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM)

(2019) Gangireddy Sujeevan Reddy et al.   BIOORGANIC CHEMISTRY

Pyrrolo[3,4-c]pyrazole Synthesis via Copper(Ι) Chloride-Catalyzed Oxidative Coupling of Hydrazones to Maleimides

(2019) Jia-Nan Zhu et al.   ORGANIC LETTERS

One-Pot Highly Regioselective Synthesis of α-Ketoamide N-Arylpyrazoles from Secondary β-Enamino Diketones

(2019) Julia Poletto et al.   ORGANIC LETTERS

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

(2019) Safaa M. Kishk et al.   ChemistryOpen

Targeting malaria and leishmaniasis: Synthesis and pharmacological evaluation of novel pyrazole-1,3,4-oxadiazole hybrids. Part II

(2019) Garima Verma et al.   BIOORGANIC CHEMISTRY

Design, synthesis, modeling studies and biological screening of novel pyrazole derivatives as potential analgesic and anti-inflammatory agents

(2019) Azza T. Taher et al.   BIOORGANIC CHEMISTRY

Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

(2019) Nika Strašek et al.   BIOORGANIC CHEMISTRY

New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents

(2019) Khaled RA Abdellatif et al.   Future Medicinal Chemistry

Pyrazole–Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

(2019) Bo He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Iodine-Catalyzed Regioselective Oxidative Cyclization of Aldehyde Hydrazones with Electron-Deficient Olefins for the Synthesis of Mefenpyr-Diethyl

(2019) Jia-Nan Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements

(2019) Christine A. Dimirjian et al.   ORGANIC LETTERS

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

(2019) Dimmito et al.   Biomolecules

An efficient method for the synthesis of novel derivatives 4-{5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide and their anti-inflammatory potential

(2019) Ghulam Mustafa et al.   BIOORGANIC CHEMISTRY

Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities

(2019) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents

(2019) Zabiulla et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agents

(2019) Garima Bansal et al.   BIOORGANIC CHEMISTRY

Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma

(2019) Samy Mohamady et al.   BIOORGANIC CHEMISTRY

New library of pyrazole–imidazo[1,2‐α]pyridine molecular conjugates: Synthesis, antibacterial activity and molecular docking studies

(2019) Oluwakemi Ebenezer et al.   Chemical Biology & Drug Design

Novel 5‐(1‐aryl‐1 H ‐pyrazol‐3‐yl)‐1 H ‐tetrazoles as glycogen phosphorylase inhibitors: An in vivo antihyperglycemic activity study

(2019) Pramod P. Kattimani et al.   DRUG DEVELOPMENT RESEARCH

Synthesis of 1H-Pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl Soft-Lewis Basic Complexants via Metal and Oxidant Free [3 + 2] Dipolar Cycloaddition of Terminal Ethynyl Pyridines with Tosylhydrazides

(2019) Giri Babu Veerakanellore et al.   JOURNAL OF ORGANIC CHEMISTRY

New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies

(2019) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors

(2019) Vinay Pogaku et al.   BIOORGANIC CHEMISTRY

Synthesis, reactions, and spectral characterization of some new biologically active compounds derived from thieno[2,3‐ c ]pyrazole‐5‐carboxamide

(2019) Ahmed F. Saber et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, synthesis of novel (Z)-2-(3-(4-((3-benzyl-2,4-dioxothiazolidin-5-ylidene)methyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide derivatives: Evaluation of cytotoxic activity and molecular docking studies

(2019) Prashanth Kumar Kolluri et al.   JOURNAL OF MOLECULAR STRUCTURE

(3 + 1) Annulation/Rearrangement Cascade of C,N-Cyclic Azomethine Imines and 3-Chlorooxindoles: Construction of Hexahydroindeno[2,1-c]pyrazole Spirooxindole Frameworks

(2019) Peng-Fei Zheng et al.   ORGANIC LETTERS

Silver-catalyzed synthesis of 5-aryl-3-trifluoromethyl pyrazoles

(2019) Yihui Xu et al.   TETRAHEDRON LETTERS

Hybrids of Isatin‐Pyrazole as Potential α‐Glucosidase Inhibitors: Synthesis, Biological Evaluations and Molecular Docking Studies

(2019) Ramandeep Kaur et al.   ChemistrySelect

Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues

(2018) Parvesh Singh et al.   MEDICINAL CHEMISTRY RESEARCH

Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

(2018) Nikalet Everson et al.   TETRAHEDRON LETTERS

Visible-light promoted one-pot synthesis of pyrazoles from alkynes and hydrazines

(2018) Yunge Meng et al.   TETRAHEDRON LETTERS

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors

(2018) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

Selective, Metal-Free Approach to 3- or 5-CF3-Pyrazoles: Solvent Switchable Reaction of CF3-Ynones with Hydrazines

(2017) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Review: biologically active pyrazole derivatives

(2017) Anam Ansari et al.   NEW JOURNAL OF CHEMISTRY

Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents

(2016) Raquib Alam et al.   BIOORGANIC CHEMISTRY

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

(2010) Yeeman K. Ramtohul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Biological Activity, and Molecular Modeling Studies of 1H-1,2,3-Triazole Derivatives of Carbohydrates as α-Glucosidases Inhibitors

(2010) Sabrina B. Ferreira et al.   JOURNAL OF MEDICINAL CHEMISTRY