New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies

Published 2020 View Full Article

Title

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies

Authors

Keywords

Anti-inflammatory, Pyrazole, 1,2,4-Triazole, Nitric oxide donor, Cyclooxygenase-2 inhibitors, Anti-cancer, Gene expression, Molecular docking, Ulcerogenicity, Apoptosis

Journal

BIOORGANIC CHEMISTRY

Volume 98, Issue -, Pages 103752

Publisher

Elsevier BV

Online

2020-03-13

DOI

10.1016/j.bioorg.2020.103752

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