Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib

Fluorinated Pyrazoles: From Synthesis to Applications

(2021) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene

(2020) Chuanle Zhu et al.   ORGANIC LETTERS

Access to 2-Alkyl/Aryl-4-(1H)-Quinolones via Orthogonal “NH3” Insertion into o-Haloaryl Ynones: Total Synthesis of Bioactive Pseudanes, Graveoline, Graveolinine, and Waltherione F

(2020) Shweta Singh et al.   ORGANIC LETTERS

Copper-Catalyzed Thiolation of Terminal Alkynes Employing Thiocyanate as the Sulfur Source Leading to Enaminone-Based Alkynyl Sulfides under Ambient Conditions

(2020) Chandran R. et al.   ORGANIC LETTERS

2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943

(2020) Pavel K. Mykhailiuk   CHEMICAL REVIEWS

An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors

(2019) Vinay Kumar Sthalam et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

(2019) Bohdan A. Chalyk et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron-Catalyzed Transfer Hydrogenation in Aged N-Methyl-2-pyrrolidone: Reductive Ring-Opening of 3,5-Disubstituted Isoxazoles and Isoxazolines

(2019) Xiaochen Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper(i)-catalyzed N–H olefination of sulfonamides for N-sulfonyl enaminone synthesis

(2018) Xiao Liang et al.   CHEMICAL COMMUNICATIONS

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

(2018) Alex G. Baldwin et al.   ChemMedChem

Polysubstituted 3-trifluoromethylpyrazoles: regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

(2018) Greta Utecht et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multifunctionalization of Unactivated Cyclic Ketones via Synergistic Catalysis of Copper and Diarylamine: Access to Cyclic α-Enaminone

(2018) Yang Li et al.   ORGANIC LETTERS

Cu-Catalyzed Synthesis of Fluoroalkylated Isoxazoles from Commercially Available Amines and Alkynes

(2018) Xiao-Wei Zhang et al.   ORGANIC LETTERS

Synthesis of Celecoxib, Mavacoxib, SC-560, Fluxapyroxad, and Bixafen Enabled by Continuous Flow Reaction Modules

(2017) Joshua Britton et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Difluoromethyl Nitrile Oxide (CF2 HCNO): A Neglected Chemical Reagent

(2017) Andrii Khutorianskyi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective, Metal-Free Approach to 3- or 5-CF3-Pyrazoles: Solvent Switchable Reaction of CF3-Ynones with Hydrazines

(2017) Vasiliy M. Muzalevskiy et al.   JOURNAL OF ORGANIC CHEMISTRY

Gold(I)/Gold(III)-Catalyzed Selective Synthesis of N-Sulfonyl Enaminone Isomers from Sulfonamides and Ynones via Two Distinct Reaction Pathways

(2017) Dabon Lee et al.   ORGANIC LETTERS

Organocatalytic activation of isocyanides: N-heterocyclic carbene-catalyzed enaminone synthesis from ketones

(2017) Jungwon Kim et al.   Chemical Science

Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2016) Zsófia E. Blastik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

(2016) Lucas Mertens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C–H arylation

(2016) Jian-Siang Poh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solvent- and Transition Metal Catalyst-Dependent Regioselectivity in the [3+2] Cyclocondensation of Trifluoromethyl-α,β-ynones with Hydrazines: Switchable Access to 3- and 5-Trifluoromethylpyrazoles

(2015) Min-Tsang Hsieh et al.   ADVANCED SYNTHESIS & CATALYSIS

In Situ Generation of Difluoromethyl Diazomethane for [3+2] Cycloadditions with Alkynes

(2015) Pavel K. Mykhailiuk   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated isoxazolines and isoxazoles: A synthetic perspective

(2015) Vinod Kumar et al.   JOURNAL OF FLUORINE CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated enol ethers: their synthesis and reactivity

(2015) M. Decostanzi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Acetylide Ion (C22−) as a Synthon To Link Electrophiles and Nucleophiles: A Simple Method for Enaminone Synthesis

(2013) Dingyi Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

(2013) Raoni S B Gonçalves et al.   Beilstein Journal of Organic Chemistry

Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

(2013) Szabolcs Kovács et al.   TETRAHEDRON

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

(2011) Steven M. Gaulier et al.   TETRAHEDRON LETTERS

Diamine ligands in copper-catalyzed reactions

(2010) David S. Surry et al.   Chemical Science

Synthesis and Antifungal Activity of β-Trifluoroalkyl Aminovinyl Ketone Derivatives

(2009) Gary Gellerman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

2-(N-Alkylamino)-1-(trifluoroacetimidoyl)vinyl ketone derivatives as potential reagents in heterocyclic synthesis

(2009) L. S. Vasil’ev et al.   RUSSIAN CHEMICAL BULLETIN

Solid-State Synthesis of β-Enamino Ketones from Solid 1,3-Dicarbonyl Compounds and Ammonium Salts or Amines

(2009) Jing-Hua Li et al.   SYNLETT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS