Caloric Restriction Mimetic 2-Deoxyglucose Reduces Inflammatory Signaling in Human Astrocytes: Implications for Therapeutic Strategies Targeting Neurodegenerative Diseases

Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases

(2021) Zsolt Kovács et al.   Nutrients

Metabolism‐based therapies for epilepsy: new directions for future cures

(2021) Mackenzie Cervenka et al.   Annals of Clinical and Translational Neurology

A ketogenic diet affects brain volume and metabolome in juvenile mice

(2021) Shyamchand Mayengbam et al.   NEUROIMAGE

Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders

(2021) Jessica Proulx et al.   Frontiers in Neuroscience

The Role of Neuroinflammation in Cellular Damage in Neurodegenerative Diseases

(2020) Sangu Muthuraju et al.   Biomed Research International

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

(2020) Dae-Sung Hwangbo et al.   Nutrients

Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma

(2020) Nicholas A. Devanney et al.   EXPERIMENTAL NEUROLOGY

Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine Neurons

(2020) Partha Dabke et al.   Nutrients

HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration

(2020) Kalaiselvi Sivalingam et al.   MOLECULAR NEUROBIOLOGY

AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

(2020) Ranjithmenon Muraleedharan et al.   Cell Reports

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms

(2020) Clotilde Laussel et al.   BIOCHEMICAL PHARMACOLOGY

Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND

(2019) Bianca Cotto et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders

(2019) Bianca Cotto et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia

(2019) Mary K. Swinton et al.   NEUROBIOLOGY OF DISEASE

Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice

(2019) Jerel Adam Fields et al.   Scientific Reports

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

(2019) B. Pajak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

(2019) Joachim W. Deitmer et al.   Frontiers in Neuroscience

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

(2018) Ruby Macdonald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology

(2018) Joyshree Biswas et al.   CELLULAR SIGNALLING

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

(2018) Inhae Kang et al.   FEBS LETTERS

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

(2018) IsaacG Onyango   Neural Regeneration Research

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Control in Neurons by the Ketogenic Diet

(2018) Nagisa Sada et al.   Frontiers in Cellular Neuroscience

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

(2018) Kalimuthusamy Natarajaseenivasan et al.   Cell Death & Disease

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The metabolic trinity, glucose–glycogen–lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression

(2017) Gerald A. Dienel   NEUROSCIENCE LETTERS

Complement Component 3 Is Associated with Metabolic Comorbidities in Older HIV-Positive Adults

(2016) Alex K. Bryant et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Effects of Comorbid Depression and Diabetes Mellitus on Cognitive Decline in Older Mexican Americans

(2016) Brian Downer et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

(2015) A Sami Saribas et al.   CELL CYCLE

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy

(2015) Jui Pandhare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Hypoglycemia-Induced Neuronal Death by β-Hydroxybutyrate Involves the Preservation of Energy Levels and Decreased Production of Reactive Oxygen Species

(2015) Alberto Julio-Amilpas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1

(2015) Mark F. McCarty et al.   MEDICAL HYPOTHESES

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes

(2012) Jerel Fields et al.   Journal of Neuroinflammation

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1

(2011) Jerel Fields et al.   JOURNAL OF NEUROCHEMISTRY

Reactive astrocytes as therapeutic targets for CNS disorders

(2010) Mary E. Hamby et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study

(2007) Leo T.M. Van der Ven et al.   TOXICOLOGY