Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

(2019) Yonatan Ganor et al.   Nature Microbiology

Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia

(2019) Mary K. Swinton et al.   NEUROBIOLOGY OF DISEASE

Association of antiretroviral therapy with brain aging changes among HIV-infected adults

(2018) Virawudh Soontornniyomkij et al.   AIDS

Polymorphisms in P2X4R and CAMKK2 may affect TNFα production: Implications for a role in HIV-associated sensory neuropathy

(2018) Jessica Gaff et al.   HUMAN IMMUNOLOGY

Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies

(2018) Josep M Llibre et al.   LANCET

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

(2018) Kalimuthusamy Natarajaseenivasan et al.   Cell Death & Disease

Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy

(2018) Jerel Adam Fields et al.   JOURNAL OF NEUROCHEMISTRY

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy

(2018) Allen Ko et al.   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus Type-1 gp120 and Tat Induce Mitochondrial Fragmentation and Incomplete Mitophagy in Human Neurons

(2018) Carmen Teodorof-Diedrich et al.   JOURNAL OF VIROLOGY

HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs

(2018) Justin Cohen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro

(2017) Peipei Xu et al.   Journal of Neuroimmune Pharmacology

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs

(2017) Justin Cohen et al.   Frontiers in Aging Neuroscience

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity

(2016) Jerel A. Fields et al.   Journal of Neuroinflammation

Erratum: HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders

(2016) Jerel Adam Fields et al.   NEUROBIOLOGY OF DISEASE

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tenofovir Disoproxil Fumarate

(2015) Hanna H. Ng et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression

(2015) Edana Cassol et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV

(2015) Andrew J. Levine et al.   JOURNAL OF NEUROVIROLOGY

Mechanisms of distal axonal degeneration in peripheral neuropathies

(2015) Christopher R. Cashman et al.   NEUROSCIENCE LETTERS

Antiretroviral Treatment Efficacy and Safety in Older HIV-Infected Adults

(2015) Jacqueline Jourjy et al.   PHARMACOTHERAPY

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

(2015) Benjamin B. Gelman   Current HIV/AIDS Reports

Astrocytic metabolic and inflammatory changes as a function of age

(2014) Tianyi Jiang et al.   AGING CELL

Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment

(2014) Edana Cassol et al.   AIDS

Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study

(2014) R. K. Heaton et al.   CLINICAL INFECTIOUS DISEASES

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

(2014) Martine Uittenbogaard et al.   CURRENT PHARMACEUTICAL DESIGN

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

(2014) Cagla Akay et al.   JOURNAL OF NEUROVIROLOGY

Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

(2014) Vez Repunte-Canonigo et al.   Molecular Neurodegeneration

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Declines in Drp1 and Parkin Expression Underlie DNA Damage-Induced Changes in Mitochondrial Length and Neuronal Death

(2013) D. B. Wang et al.   JOURNAL OF NEUROSCIENCE

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer

(2013) Jerel Fields et al.   JOURNAL OF NEUROVIROLOGY

Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

(2013) Huichao Chen et al.   JOURNAL OF NEUROVIROLOGY

Epigenetic Regulation of HIV-1 Latency in Astrocytes

(2013) S. D. Narasipura et al.   JOURNAL OF VIROLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Antiretroviral neurotoxicity

(2012) Kevin Robertson et al.   JOURNAL OF NEUROVIROLOGY

The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits

(2012) Xuan Ye et al.   NEUROBIOLOGY OF AGING

Tenofovir Selectively Regulates Production of Inflammatory Cytokines and Shifts the IL-12/IL-10 Balance in Human Primary Cells

(2011) Jesper Melchjorsen et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Tenofovir renal proximal tubular toxicity is regulated By OAT1 and MRP4 transporters

(2011) James J Kohler et al.   LABORATORY INVESTIGATION

Activation of p38 MAPK Is Required in Monocytic and Neuronal Cells for HIV Glycoprotein 120-Induced Neurotoxicity

(2010) K. E. Medders et al.   JOURNAL OF IMMUNOLOGY

A rotarod test for evaluation of motor skill learning

(2010) Hiromi Shiotsuki et al.   JOURNAL OF NEUROSCIENCE METHODS

Tenofovir renal toxicity targets mitochondria of renal proximal tubules

(2009) James J Kohler et al.   LABORATORY INVESTIGATION

Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy

(2009) L. A. Cysique et al.   NEUROLOGY

Neuropsychological Functioning and Antiretroviral Treatment in HIV/AIDS: A Review

(2009) Lucette A. Cysique et al.   NEUROPSYCHOLOGY REVIEW

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy

(2008) Ronald J. Ellis et al.   ANNALS OF NEUROLOGY

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

HIV-1-Infected Astrocytes and the Microglial Proteome

(2008) Tong Wang et al.   Journal of Neuroimmune Pharmacology