HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration

HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders

(2019) Bianca Cotto et al.   PROGRESS IN NEUROBIOLOGY

Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia

(2019) Mary K. Swinton et al.   NEUROBIOLOGY OF DISEASE

Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters

(2018) Samikkannu Thangavel et al.   ANTIOXIDANTS & REDOX SIGNALING

Synapse Pruning: Mitochondrial ROS with Their Hands on the Shears

(2018) James N. Cobley   BIOESSAYS

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

(2018) Kalimuthusamy Natarajaseenivasan et al.   Cell Death & Disease

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

Undercover: gene control by metabolites and metabolic enzymes

(2016) Jan A. van der Knaap et al.   GENES & DEVELOPMENT

HIV-1 Tat and Cocaine Impair Survival of Cultured Primary Neuronal Cells via a Mitochondrial Pathway

(2016) Francesca Isabella De Simone et al.   Journal of Neuroimmune Pharmacology

HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway

(2016) Y. Fan et al.   JOURNAL OF NEUROSCIENCE

HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling

(2016) Thangavel Samikkannu et al.   Scientific Reports

Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients

(2015) Alex M. Dickens et al.   AIDS

HIV-1 Subtypes B and C Tat Differentially Impact Synaptic Plasticity Expression and Implicates HIV-Associated Neurocognitive Disorders§

(2015) Thangavel Samikkannu et al.   CURRENT HIV RESEARCH

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

(2015) Divya Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Acetyl Cysteine Mitigates the Acute Effects of Cocaine-Induced Toxicity in Astroglia-Like Cells

(2015) Ramesh B. Badisa et al.   PLoS One

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Immunoneuropathogenesis of HIV-1 clades B and C: Role of redox expression and thiol modification

(2014) Thangavel Samikkannu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Total antioxidant capacity is significantly lower in cocaine-dependent and methamphetamine-dependent patients relative to normal controls: results from a preliminary study

(2014) Jessica Walker et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

(2013) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

(2013) Rianne Nederlof et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

(2013) Rita Perfeito et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIV infection and drugs of abuse: role of acute phase proteins

(2013) Thangavel Samikkannu et al.   Journal of Neuroinflammation

Target analysis by integration of transcriptome and ChIP-seq data with BETA

(2013) Su Wang et al.   Nature Protocols

Effects of Conditional Central Expression of HIV-1 Tat Protein to Potentiate Cocaine-Mediated Psychostimulation and Reward Among Male Mice

(2013) Jason J Paris et al.   NEUROPSYCHOPHARMACOLOGY

Peripheral toxicity in crack cocaine use disorders

(2013) Joana C.M. Narvaez et al.   NEUROSCIENCE LETTERS

Human Synaptic Plasticity Gene Expression Profile and Dendritic Spine Density Changes in HIV-Infected Human CNS Cells: Role in HIV-Associated Neurocognitive Disorders (HAND)

(2013) Venkata Subba Rao Atluri et al.   PLoS One

Mechanism(s) Involved in Opioid Drug Abuse Modulation of HAND

(2012) Raini Dutta et al.   CURRENT HIV RESEARCH

Cocaine and HIV-1 Interplay in CNS: Cellular and Molecular Mechanisms

(2012) Shilpa Buch et al.   CURRENT HIV RESEARCH

Contribution of Oxidative Metabolism to Cocaine-Induced Liver and Kidney Damage

(2012) M.J. Valente et al.   CURRENT MEDICINAL CHEMISTRY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

(2012) Ivana Cacciatore et al.   Oxidative Medicine and Cellular Longevity

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS

(2011) Thangavel Samikkannu et al.   JOURNAL OF NEUROVIROLOGY

Brain creatine elevation and N-acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of NeuroAIDS

(2011) Eva-Maria Ratai et al.   MAGNETIC RESONANCE IN MEDICINE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Role of Astrocytes in Brain Function and Disease

(2010) Marta Sidoryk-Wegrzynowicz et al.   TOXICOLOGIC PATHOLOGY

Illicit drug use and HIV treatment outcomes in a US cohort

(2009) Joseph Cofrancesco et al.   AIDS

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crack-Cocaine Use Accelerates HIV Disease Progression in a Cohort of HIV-Positive Drug Users

(2008) Marianna K Baum et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death

(2008) H. J. Kim et al.   JOURNAL OF NEUROSCIENCE