Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain

Emerging Roles of Extracellular Vesicles in the Central Nervous System: Physiology, Pathology, and Therapeutic Perspectives

(2021) Yadaly Gassama et al.   Frontiers in Cellular Neuroscience

Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome

(2021) Pasquale D’Acunzo et al.   Science Advances

Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

(2021) Kiran Todkar et al.   Nature Communications

Quantification of Circulating Cell Free Mitochondrial DNA in Extracellular Vesicles with PicoGreen™ in Liquid Biopsies: Fast Assessment of Disease/Trauma Severity

(2021) Michela Marcatti et al.   Cells

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study

(2020) Anna Picca et al.   Journal of Clinical Medicine

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

The Messenger Apps of the cell: Extracellular Vesicles as Regulatory Messengers of Microglial Function in the CNS

(2020) Adeyemi A. Olanrewaju et al.   Journal of Neuroimmune Pharmacology

Mechanisms of mitochondrial DNA escape and its relationship with different metabolic diseases

(2020) Perla Pérez-Treviño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

(2020) William A. Banks et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Mitochondrial DNA in extracellular vesicles declines with age

(2020) Stephanie Lazo et al.   AGING CELL

Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles

(2020) Kyoung Mi Kim et al.   Frontiers in Cell and Developmental Biology

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

Mitochondria Are a subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

(2019) Florian Puhm et al.   CIRCULATION RESEARCH

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

(2019) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

(2019) Matteo Bordi et al.   Cell Death & Disease

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Extracellular Vesicles as Therapeutics for Brain Injury and Disease

(2019) Dinesh Upadhya et al.   CURRENT PHARMACEUTICAL DESIGN

Promise of extracellular vesicles for diagnosis and treatment of epilepsy

(2019) Dinesh Upadhya et al.   EPILEPSY & BEHAVIOR

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

(2018) Anna Picca et al.   REJUVENATION RESEARCH

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

(2018) Mea M. Holm et al.   TRENDS IN NEUROSCIENCES

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

(2018) Irene Tsilioni et al.   Journal of Neuroinflammation

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets

(2017) Anna Picca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Classification of advanced stages of Parkinson’s disease: translation into stratified treatments

(2017) Rejko Krüger et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation

(2017) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

(2017) Ilija Melentijevic et al.   NATURE

Extracellular vesicles are independent metabolic units with asparaginase activity

(2017) Nunzio Iraci et al.   Nature Chemical Biology

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

(2017) Anne-lie Ståhl et al.   PEDIATRIC NEPHROLOGY

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Maintenance and Expression of Mammalian Mitochondrial DNA

(2016) Claes M. Gustafsson et al.   Annual Review of Biochemistry

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

(2016) Koji Yamano et al.   EMBO REPORTS

The geriatric management of frailty as paradigm of “The end of the disease era”

(2016) Matteo Cesari et al.   European Journal of Internal Medicine

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes as Novel Regulators of Adult Neurogenic Niches

(2016) Luis Federico Bátiz et al.   Frontiers in Cellular Neuroscience

Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers

(2016) Stephanie N. Hurwitz et al.   Oncotarget

Down syndrome and Alzheimer's disease: Common pathways, common goals

(2015) Dean Hartley et al.   Alzheimers & Dementia

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

(2015) Wenzhang Wang et al.   NATURE MEDICINE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

(2015) Shivakumar Keerthikumar et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens

(2014) Adam Fleming et al.   Pathogens and Disease

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

(2010) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

(2008) Margaret Neuspiel et al.   CURRENT BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY