Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants

Protective Effects of GYY4137 on Renal Ischaemia/Reperfusion Injury through Nrf2-Mediated Antioxidant Defence

(2021) Hongmei Zhao et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Targeting oxidative stress, a crucial challenge in renal transplantation outcome

(2021) Romain Carcy et al.   FREE RADICAL BIOLOGY AND MEDICINE

A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy

(2020) Amel Karaa et al.   Journal of Cachexia Sarcopenia and Muscle

Kidney allograft fibrosis: what we learned from latest translational research studies

(2020) Simona Granata et al.   JOURNAL OF NEPHROLOGY

Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats

(2020) Naren Bao et al.   MEDIATORS OF INFLAMMATION

Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1/Parkin-Mediated Mitophagy

(2020) Dong-Ju Zhu et al.   Frontiers in Physiology

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism

(2020) W. Reid Thompson et al.   GENETICS IN MEDICINE

XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

(2020) Zhi Zhao et al.   Cell Death & Disease

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury

(2020) Gui-Ping Jiang et al.   Molecular Medicine Reports

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

(2019) Valentina Masola et al.   Journal of Translational Medicine

Purine Release, Metabolism, and Signaling in the Inflammatory Response

(2019) Joel Linden et al.   Annual Review of Immunology

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

Augmenter of liver regeneration protects the kidney from ischaemia‐reperfusion injury in ferroptosis

(2019) Li‐li Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

(2019) Chengyuan Tang et al.   Cell Death & Disease

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

(2019) Lianjiu Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury

(2019) Jean-Christophe Wyss et al.   Frontiers in Pharmacology

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

(2018) Lorena Esteban-Martínez et al.   Autophagy

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway

(2018) Nan Li et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

(2018) Anja Jelinek et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

The Relationships Between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-Related Costs

(2018) Oscar K. Serrano et al.   TRANSPLANTATION

Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling

(2018) Giuseppe Castellano et al.   Frontiers in Immunology

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Direct observation of selective autophagy induction in cells and tissues by self-assembled chiral nanodevice

(2018) Maozhong Sun et al.   Nature Communications

Augmenter of liver regeneration: A fundamental life protein

(2017) Michael A. Nalesnik et al.   HEPATOLOGY

The Nrf2/HO-1 Pathway Mediates the Antagonist Effect of L-Arginine On Renal Ischemia/Reperfusion Injury in Rats

(2017) Fei Tong et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression

(2017) Masahiro Nezu et al.   KIDNEY INTERNATIONAL

Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI

(2017) Xiaoge Liu et al.   MAGNETIC RESONANCE IN MEDICINE

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury

(2016) Aleksandra Kezic et al.   Oxidative Medicine and Cellular Longevity

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

(2015) Nadezda Apostolova et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury

(2015) Sang Jun Han et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mitochondria: a new therapeutic target in chronic kidney disease

(2015) Simona Granata et al.   Nutrition & Metabolism

The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats

(2015) Murat Cakir et al.   RENAL FAILURE

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury

(2014) S. Simone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Predictive model for delayed graft function based on easily available pre-renal transplant variables

(2014) Gianluigi Zaza et al.   Internal and Emergency Medicine

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationale and design of the EMBRACE STEMI Study: A phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction

(2013) Anjan K. Chakrabarti et al.   AMERICAN HEART JOURNAL

Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice

(2013) Gil-Tae Gang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Augmenter of Liver Regeneration Attenuates Tubular Cell Apoptosis in Acute Kidney Injury in Rats: The Possible Mechanisms

(2012) Xiao-hui Liao et al.   RENAL FAILURE

Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes

(2011) M. Tonelli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

(2011) Nobuhiko Harada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Animal and human studies with the mitochondria-targeted antioxidant MitoQ

(2010) Robin A.J. Smith et al.   Annals of the New York Academy of Sciences

Mitochondrial fission and fusion

(2010) Iain Scott et al.   Essays in Biochemistry

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats

(2010) X.-h. Liao et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study

(2009) Pinpat Tripatara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury

(2009) E. M. Bos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

(2009) Manchang Liu et al.   KIDNEY INTERNATIONAL

Translation of remote ischaemic preconditioning into clinical practice

(2009) Rajesh K Kharbanda et al.   LANCET

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Rat Kidney: A Histopathologic Study

(2009) Hasan Kocoglu et al.   RENAL FAILURE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction

(2008) Pinpat Tripatara et al.   LABORATORY INVESTIGATION

Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis

(2008) S. G. Yarlagadda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION