Review
Pharmacology & Pharmacy
Palak P. Oza, Khosrow Kash
Summary: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three endogenously produced gases with important functions in the vasculature, immune defense, and inflammation. They modulate each other's activity and have dual effects on different aspects of cancer biology. The roles of NO, CO, and H2S in cancer are complex and can have both tumor-promoting and anti-tumor effects.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Ophthalmology
Selcuk Takir, Ayca Toprak Semiz, B. Sonmez Uydes Dogan
Summary: The study investigated the concentration levels and distribution profiles of H2S synthesizing enzymes in the bovine retina and retinal artery. CBS and CSE were found to have higher concentrations in the retinal artery compared to the retina, with 3-MST at the lowest level. The distribution of these enzymes also varied, with CBS found in endothelial and smooth muscle layers, while CSE was mainly present in the endothelial layer of the retinal artery.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jae-Ho Lee, Seung-Soon Im
Summary: This review discusses the function of hydrogen sulfide (H2S) in liver diseases, and summarizes the recent roles of H2S in several cellular processes of the liver.
Article
Chemistry, Multidisciplinary
Fang-fang Cai, Huang-ru Xu, Shi-hui Yu, Ping Li, Yan-yan Lu, Jia Chen, Zhi-qian Bi, Hui-song Sun, Jian Cheng, Hong-qin Zhuang, Zi-chun Hua
Summary: The study demonstrated that ADT-OH inhibits the EMT process in melanoma cells and their proliferation, exerting anti-metastatic effects.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Plant Sciences
Yu-Ying Sun, Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study found that nitric oxide (NO) can enhance thermotolerance in maize seedlings by triggering the LCD/H2S signaling pathway. Additionally, NO also improves the adaptability of maize seedlings to heat stress by regulating the activity of the ROS scavenging system.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Biomedical
Andre J. van der Vlies, Masoud Ghasemi, Bernadette M. Adair, James H. Adair, Enrique D. Gomez, Urara Hasegawa
Summary: Hydrogen sulfide (H2S) is a gaseous signaling molecule with regulatory roles in cancer cell proliferation and migration, making it of interest in cancer therapy. Controlled delivery of H2S has been a challenge, but polymeric micelles containing H2S donating groups offer a solution. These micelles release H2S upon oxidation by reactive oxygen species (ROS) present inside cancer cells, with the release profiles controlled by changing the polymer design. In vitro and in vivo experiments demonstrate that micelles with moderate H2S release rates have the strongest anti-proliferative effect in human colon cancer cells and the chick chorioallantoic membrane cancer model, while not affecting human umbilical vein endothelial cell proliferation. This study highlights the importance of fine-tuning H2S release profiles using a micelle approach for maximizing the therapeutic potential of H2S in cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Adrian T. Press, Luisa Ungelenk, Anna Medyukhina, Samantha A. Pennington, Sandor Nietzsche, Chunyi Kan, Amelie Lupp, Uta Dahmen, Rui Wang, Utz Settmacher, Reinhard Wetzker, Marc Thilo Figge, Mark G. Clemens, Michael Bauer
Summary: Ischemia-reperfusion injury, characterized by the deprivation of antioxidants and energy, poses a critical threat to the liver during transplantation, trauma, or shock. This study examines the role of hydrogen sulfide as an antioxidant in the liver and the therapeutic potential of sodium sulfide (Na2S) and sodium thiosulfate (STS) as hydrogen sulfide donors. The results demonstrate that STS refuels and protects the liver's antioxidant pool, effectively reducing lipid peroxidation and mitochondrial damage, leading to the preservation of liver tissue architecture.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Plant Sciences
Dandan Huang, Guangqin Jing, Lili Zhang, Changbao Chen, Shuhua Zhu
Summary: NO, H2S, and ROS play essential signaling roles in cells through oxidative post-translational modification within suitable ranges of concentration to maintain redox balance and regulate DNA repair pathways, including mtDNA. The interactions among them are intricate, influencing their generation, elimination, and signaling actions. Additionally, NO and H2S may be involved in epigenetic variations in DNA damage repair of plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Analytical
Ryan E. Johnson, Joshua M. van der Zalm, Aicheng Chen, Ian J. Bell, Terence J. Van Raay, M. Sameer Al-Abdul-Wahid, Richard A. Manderville
Summary: This article describes a hemicyanine hybrid probe containing 7-(diethylamino)coumarin (ACou) donor and cationic indolenium (Ind) acceptor, which is used for detecting nucleophilic analytes such as cyanide and reactive sulfur species (RSS). The study reveals that thiolates react with ACou-Ind through conjugate addition to form C4-SR adducts, and ACou-Ind serves as a turn-off probe by losing red ICT fluorescence upon RSS addition. Moreover, the article discusses that the blue coumarin emission of thiolate adducts does not enhance in the presence of reactive oxygen species (ROS), but undergoes oxidative deconjugation in the presence of ROS H2O2. The relevance of the chemosensing mechanism for ACou-Ind is assessed in live zebrafish, and the implications for the interplay between RSS and ROS are discussed.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Blaze M. Pharoah, Vinayak S. Khodade, Alexander Eremiev, Eric Bao, Ting Liu, Brian O'Rourke, Nazareno Paolocci, John P. Toscano
Summary: Hydrogen sulfide (H2S) has protective effects in cardiovascular disease, but its mechanism of action is still unclear. Recent studies have found that H2S can modulate protein activity through redox-based post-translational modifications. Other reactive sulfur species also exhibit cardioprotective action. Exogenous hydropersulfide donation is a superior approach compared to other reactive sulfur species and mechanical post-conditioning in protecting cardiac function and limiting infarct size.
Review
Biochemistry & Molecular Biology
Quan Gu, Qingqing Xiao, Ziping Chen, Yi Han
Summary: Melatonin acts as a multifunctional molecule in plants, particularly in protecting against abiotic stresses. It interacts with signaling molecules such as reactive oxygen species (ROS), nitric oxide (NO), and hydrogen sulfide (H2S) to modulate plant responses to abiotic stresses and enhance plant tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tajammul Husain, Mohammad Suhel, Sheo Mohan Prasad, Vijay Pratap Singh
Summary: Research has shown that both ethylene and hydrogen sulfide have the potential to alleviate the toxicity of hexavalent chromium in crop plants, with endogenous H2S playing a crucial role in the ET-mediated mitigation of Cr(VI) stress.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Andrea Doman, Eva Doka, Dorottya Garai, Virag Bogdandi, Gyorgy Balla, Jozsef Balla, Peter Nagy
Summary: Reactive sulfur species, including H2S, have emerged as important effector molecules in biological events. They interact with metalloproteins to exert their biological roles, altering fundamental cellular functions and contributing to immune defense, cellular protection against oxidative stress, and redox signaling. Understanding the interactions between RSS and metal centers is crucial for drug development and advancements in redox medicine.
Article
Plant Sciences
Deepti Singh, Nathi Lal Sharma, Dharmendra Singh, Manzer H. Siddiqui, Jyoti Taunk, Susheel Kumar Sarkar, Abhishek Rathore, Chandan Kumar Singh, Abdullah A. Al-amri, Saleh Alansi, Hayssam M. Ali, Md Atikur Rahman
Summary: This study investigated the effects of highly toxic chromium ions on the growth and physio-biochemical performance of mungbeans. It was found that the exogenous application of hydrogen sulfide promoted plant growth, improved antioxidant activities, and reduced cell death by suppressing chromium accumulation and translocation. These findings highlight the importance of hydrogen sulfide application in protecting crops against chromium toxicity.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weirun Li, Peier Chen, Yuxuan Pan, Ling Lu, Xiaodong Ning, Jiamin Liu, Jintao Wei, Minsheng Chen, Peng Zhao, Caiwen Ou
Summary: By using a complex scaffold and nanocomposite scaffold, a band-aid like patch can slowly release H2S and attach to the myocardium, relieving inflammation and promoting angiogenesis after myocardial infarction and recovering heart function.