Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A

Histone demethylase JMJD1A in cancer progression and therapeutic resistance

(2022) Hee‐Young Jeon et al.   MOLECULAR CARCINOGENESIS

Phospho-Form Specific Substrates of Protein Kinase B (AKT1)

(2021) McShane McKenna et al.   Frontiers in Bioengineering and Biotechnology

Deconvoluting complex protein interaction networks through reductionist strategies in peptide biochemistry: Modern approaches and research questions

(2021) Valentina Lukinović et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

(2021) Xin Li et al.   Journal of Hematology & Oncology

Lysine Demethylases: Promising Drug Targets in Melanoma and Other Cancers

(2021) Gaya Punnia-Moorthy et al.   Frontiers in Genetics

Identification of in vitro JMJD lysine demethylase candidate substrates via systematic determination of substrate preference

(2021) Matthew Hoekstra et al.   ANALYTICAL BIOCHEMISTRY

KDM6 Demethylases and Their Roles in Human Cancers

(2021) Chunyan Hua et al.   Frontiers in Oncology

Epigenetic Therapy for Epithelioid Sarcoma

(2020) Scott B. Rothbart et al.   CELL

Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome

(2020) Kyle K. Biggar et al.   Cell Reports

Histone methyltransferase and drug resistance in cancers

(2020) Cheng Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions

(2020) Rose Oughtred et al.   PROTEIN SCIENCE

LSD1: more than demethylation of histone lysine residues

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma

(2020) Catarina Macedo-Silva et al.   Cell Death & Disease

Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer

(2019) Hui-Yi Wang et al.   NUCLEIC ACIDS RESEARCH

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer

(2019) Barbara Majello et al.   Cancers

Lysine methylation of transcription factors in cancer

(2019) Dong Han et al.   Cell Death & Disease

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions

(2019) Anthony K. N. Chan et al.   Frontiers in Cell and Developmental Biology

Protein quantification and visualization via ultraviolet-dependent labeling with 2,2,2-trichloroethanol

(2019) Anand Chopra et al.   Scientific Reports

PeSA: A software tool for peptide specificity analysis

(2019) Emine Topcu et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis

(2019) Xu Qian et al.   MOLECULAR CELL

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

(2018) Evan M. Cornett et al.   Science Advances

Interactome mapping uncovers a general role for Numb in protein kinase regulation

(2017) Ran Wei et al.   MOLECULAR & CELLULAR PROTEOMICS

Bioluminescent High-Throughput Succinate Detection Method for Monitoring the Activity of JMJC Histone Demethylases and Fe(II)/2-Oxoglutarate-Dependent Dioxygenases

(2017) Juliano Alves et al.   SLAS Discovery

Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53

(2016) S Ramadoss et al.   ONCOGENE

Nonhistone Lysine Methylation in the Regulation of Cancer Pathways

(2016) Scott M. Carlson et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin

(2015) Lei Lu et al.   DEVELOPMENTAL CELL

Discovery of Substrates for a SET Domain Lysine Methyltransferase Predicted by Multistate Computational Protein Design

(2015) Sylvain Lanouette et al.   STRUCTURE

A scintillation proximity assay for histone demethylases

(2014) Wenyu Yu et al.   ANALYTICAL BIOCHEMISTRY

Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1

(2014) Srikanth Kudithipudi et al.   CHEMISTRY & BIOLOGY

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Diverse functions of PHD fingers of the MLL/KMT2 subfamily

(2013) Muzaffar Ali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Method for Systematic Mapping of Protein Lysine Methylation Identifies Functions for HP1β in DNA Damage Response

(2013) Huadong Liu et al.   MOLECULAR CELL

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1–mediated chromatin response to DNA breaks

(2013) Sugiko Watanabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of the Transactivation Domain of B-Myb with the TAZ2 Domain of the Coactivator p300: Molecular Features and Properties of the Complex

(2013) Ojore Oka et al.   PLoS One

Histone lysine demethylases in breast cancer

(2012) Elisa Paolicchi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity

(2012) Jingya Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

(2012) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs

(2011) Liuqing Yang et al.   CELL

Specificity Analysis-Based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase

(2011) Arunkumar Dhayalan et al.   CHEMISTRY & BIOLOGY

Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly

(2011) Ju He et al.   NUCLEIC ACIDS RESEARCH

Identification of non-histone substrates for JMJD2A–C histone demethylases

(2009) V.K. Chaithanya Ponnaluri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

(2009) Hanqiao Feng et al.   STRUCTURE

Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays

(2008) Philipp Rathert et al.   CHEMISTRY & BIOLOGY

The SIRT2 Deacetylase Regulates Autoacetylation of p300

(2008) Joshua C. Black et al.   MOLECULAR CELL

Protein lysine methyltransferase G9a acts on non-histone targets

(2008) Philipp Rathert et al.   Nature Chemical Biology