LSD1: more than demethylation of histone lysine residues

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

(2020) Yun Song et al.   Cell Reports

Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation

(2020) Roberto Ravasio et al.   Science Advances

Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression

(2020) Antonio Pezone et al.   NUCLEIC ACIDS RESEARCH

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

(2019) Michael E. Vinyard et al.   Nature Chemical Biology

Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy

(2019) Antonio Romo-Morales et al.   PEDIATRIC BLOOD & CANCER

LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity

(2019) Huiyin Lan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

(2019) Shaun Egolf et al.   Cell Reports

The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program

(2019) John Verigos et al.   Cancers

LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target

(2019) Panagiotis Karakaidos et al.   Cancers

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

(2019) Yuan Fang et al.   Journal of Hematology & Oncology

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

(2018) Sergio Regufe da Mota et al.   Cancer Cell International

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

TGF-β-mediated LEFTY/Akt/GSK-3β/Snail axis modulates epithelial-mesenchymal transition and cancer stem cell properties in ovarian clear cell carcinomas

(2018) Toshihide Matsumoto et al.   MOLECULAR CARCINOGENESIS

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

(2018) Dongha Kim et al.   MOLECULAR CELL

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation

(2018) Kotaro Anan et al.   NUCLEIC ACIDS RESEARCH

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

(2018) Archana Sehrawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

(2018) Jay H. Kalin et al.   Nature Communications

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

(2018) T. Boulding et al.   Scientific Reports

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

(2018) Alba Maiques-Diaz et al.   Cell Reports

Preclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutations

(2018) Iris F Macheleidt et al.   Molecular Oncology

Protein Language: Post-Translational Modifications Talking to Each Other

(2018) Lam Dai Vu et al.   TRENDS IN PLANT SCIENCE

LSD1-ERRα complex requires NRF1 to positively regulate transcription and cell invasion

(2018) Ling Zhang et al.   Scientific Reports

Phase I study of domatinostat (4SC-202), a class I histone deacetylase inhibitor in patients with advanced hematological malignancies

(2018) Bastian von Tresckow et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Pharmacological Inhibition of LSD1 for Cancer Treatment

(2018) Guan-Jun Yang et al.   MOLECULES

LSD1 sustains estrogen-driven endometrial carcinoma cell proliferation through the PI3K/AKT pathway via di-demethylating H3K9 of cyclin D1

(2017) Chunqin Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nucleosome–Chd1 structure and implications for chromatin remodelling

(2017) Lucas Farnung et al.   NATURE

LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis

(2017) J-Y Lee et al.   ONCOGENE

Lsd1 prevents age-programed loss of beige adipocytes

(2017) Delphine Duteil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock

(2017) Jianxun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies

(2017) Angel Chao et al.   Oncotarget

Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

(2017) Bin Peng et al.   Cell and Bioscience

ERRα protein is stabilized by LSD1 in a demethylation-independent manner

(2017) Julie Carnesecchi et al.   PLoS One

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

(2017) Chae-Seok Lim et al.   Scientific Reports

Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer

(2016) Jingxin Feng et al.   BREAST CANCER RESEARCH AND TREATMENT

Irreversible LSD1 Inhibitors: Application of Tranylcypromine and Its Derivatives in Cancer Treatment

(2016) Yi C. Zheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The mammalian circadian clock and its entrainment by stress and exercise

(2016) Yu Tahara et al.   Journal of Physiological Sciences

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP

(2016) Marcela A. Bennesch et al.   NUCLEIC ACIDS RESEARCH

LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior

(2016) Francesco Rusconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy

(2016) Yi-Chao Zheng et al.   Epigenomics

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition

(2016) Huacheng Luo et al.   Cell Reports

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

(2015) Benoit Laurent et al.   MOLECULAR CELL

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

(2015) Roshana Thambyrajah et al.   NATURE CELL BIOLOGY

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

(2015) Jianxun Wang et al.   NATURE NEUROSCIENCE

Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

(2015) Bin Peng et al.   NUCLEIC ACIDS RESEARCH

Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling

(2015) Z-J Lei et al.   ONCOGENE

LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2

(2015) Miki Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

(2015) Simona Pilotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

(2015) Rosemary C. Bagot et al.   Nature Communications

SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells

(2015) Lianhua Piao et al.   Oncotarget

Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells

(2015) Genbao Shao et al.   Scientific Reports

De novoANKRD11andKDM1Agene mutations in a male with features of KBG syndrome and Kabuki syndrome

(2014) Sanjin Tunovic et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Microexons Go Big

(2014) Li Yang et al.   CELL

Phosphorylation of H3 serine 10 by IKKα governs cyclical production of ROS in estrogen-induced transcription and ensures DNA wholeness

(2014) B Perillo et al.   CELL DEATH AND DIFFERENTIATION

LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy

(2014) Francesco Rusconi et al.   CEREBRAL CORTEX

RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts

(2014) Yang I. Li et al.   GENOME RESEARCH

Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting

(2014) Hye Jin Nam et al.   MOLECULAR CELL

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of retinoic acid-induced transcription: histone code, DNA oxidation and formation of chromatin loops

(2014) Candida Zuchegna et al.   NUCLEIC ACIDS RESEARCH

Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation

(2014) G. Upadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate

(2014) Zigmund Luka et al.   PROTEIN SCIENCE

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

(2014) Chi Kwan Tsang et al.   Nature Communications

Nuclear receptor-induced transcription is driven by spatially and timely restricted waves of ROS

(2014) Bruno Perillo et al.   Nucleus

LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6

(2014) A Ketscher et al.   Oncogenesis

Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells

(2013) Shauna N. Vasilatos et al.   CARCINOGENESIS

Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes

(2013) G. P. Vicent et al.   GENES & DEVELOPMENT

The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer

(2013) Vasundhra Kashyap et al.   Molecular Oncology

Breaking the LSD1/KDM1A Addiction: Therapeutic Targeting of the Epigenetic Modifier in AML

(2012) Alyson A. Lokken et al.   CANCER CELL

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b

(2012) Qi Zhang et al.   CELL RESEARCH

NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment

(2012) Nicola Reynolds et al.   Cell Stem Cell

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

(2012) A Sprüssel et al.   LEUKEMIA

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

(2012) Warren A. Whyte et al.   NATURE

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

(2012) Tino Schenk et al.   NATURE MEDICINE

Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome

(2012) F. McLeod et al.   NEUROSCIENCE

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

(2012) Shinjiro Hino et al.   Nature Communications

Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1

(2011) Changmeng Cai et al.   CANCER CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging

(2011) Gaston Calfa et al.   JOURNAL OF NEUROPHYSIOLOGY

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells

(2011) Antonio Adamo et al.   NATURE CELL BIOLOGY

Transcription factories in the context of the nuclear and genome organization

(2011) S. V. Razin et al.   NUCLEIC ACIDS RESEARCH

Demethylation of RB Regulator MYPT1 by Histone Demethylase LSD1 Promotes Cell Cycle Progression in Cancer Cells

(2010) H.-S. Cho et al.   CANCER RESEARCH

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function

(2010) Ze Yang et al.   CELL RESEARCH

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Cooperative interaction between retinoic acid receptor-  and estrogen receptor in breast cancer

(2010) C. S. Ross-Innes et al.   GENES & DEVELOPMENT

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System

(2010) C. Zibetti et al.   JOURNAL OF NEUROSCIENCE

Lysine Methylation Regulates E2F1-Induced Cell Death

(2010) Haroula Kontaki et al.   MOLECULAR CELL

Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

(2010) Eric Metzger et al.   NATURE

LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription

(2010) S Amente et al.   ONCOGENE

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer

(2009) Sujun Hua et al.   CELL

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

(2009) David N. Ciccone et al.   NATURE

Mechanisms involved in the regulation of histone lysine demethylases

(2008) Fei Lan et al.   CURRENT OPINION IN CELL BIOLOGY

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

(2008) Jing Wang et al.   NATURE GENETICS

Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules

(2008) Q. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

(2008) B. Perillo et al.   SCIENCE