Phospho-Form Specific Substrates of Protein Kinase B (AKT1)

Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)

(2020) Nileeka Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

(2019) Jianping Guo et al.   NATURE CELL BIOLOGY

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

(2019) Guihua Wang et al.   NATURE CELL BIOLOGY

Gld2 activity is regulated by phosphorylation in the N-terminal domain

(2019) Christina Z. Chung et al.   RNA Biology

TRAF6 interacts with and ubiquitinates PIK3CA to enhance PI3K activation

(2018) Zixi Wang et al.   FEBS LETTERS

Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity

(2018) Nileeka Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions

(2018) Ihsan Chrifi et al.   ANGIOGENESIS

Phosphorylation-Dependent Inhibition of Akt1

(2018) Nileeka Balasuriya et al.   Genes

Interactome mapping uncovers a general role for Numb in protein kinase regulation

(2017) Ran Wei et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

Clinical significance of CMTM4 expression in hepatocellular carcinoma

(2017) Chunhua Bei et al.   OncoTargets and Therapy

Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue

(2017) Carly T. Cederquist et al.   Molecular Metabolism

Rab11-FIP2 promotes colorectal cancer migration and invasion by regulating PI3K/AKT/MMP7 signaling pathway

(2016) Chang-long Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of phospho-ubiquitin variants by orthogonal translation reveals codon skipping

(2016) Susanna George et al.   FEBS LETTERS

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

(2016) J. Guo et al.   SCIENCE

Cysteinyl Leukotriene Receptor Antagonists Decrease Cancer Risk in Asthma Patients

(2016) Ming-Ju Tsai et al.   Scientific Reports

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma

(2015) Ting Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Characterization of the dehydration products due to thermal decomposition of peptides by liquid chromatography-tandem mass spectrometry

(2015) Chenglin Liu et al.   JOURNAL OF MASS SPECTROMETRY

Phosphorylation of AKT: a Mutational Analysis.

(2015) Jonathan R. Hart et al.   Oncotarget

The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma

(2014) A. Spencer et al.   BLOOD

Revealing the amino acid composition of proteins within an expanded genetic code

(2014) Hans R. Aerni et al.   NUCLEIC ACIDS RESEARCH

A Facile Strategy for Selective Incorporation of Phosphoserine into Histones

(2013) Sangsik Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

(2013) Ekta Agarwal et al.   CELLULAR SIGNALLING

Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-κB-dependent pathways

(2012) Ahmed Z El-Hashim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

(2012) C. Parikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape

(2011) Margrith E Mattmann et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Expression of pERK and pAKT in pediatric high grade astrocytomas: Correlation with YKL40 and prognostic significance

(2011) Manila Antonelli et al.   NEUROPATHOLOGY

Expanding the Genetic Code of Escherichia coli with Phosphoserine

(2011) H.-S. Park et al.   SCIENCE

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

The Extending Network of FOXO Transcriptional Target Genes

(2010) Kristan E. van der Vos et al.   ANTIOXIDANTS & REDOX SIGNALING

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas

(2010) Yoshiyuki SUZUKI et al.   JOURNAL OF RADIATION RESEARCH

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Synthesis and structure based optimization of novel Akt inhibitors

(2008) Blaise Lippa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE