Recent Advances in Multifunctional Hydrogels for the Treatment of Osteomyelitis

A gentamicin and vancomycin loaded hyaluronic-acid hydrogel successfully eradicates chronic MRSA orthopedic infection in a sheep model

(2021) Willemijn Boot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial hydrogel coating in joint mega-prosthesis: results of a comparative series

(2021) Carmine Zoccali et al.   European Journal of Orthopaedic Surgery and Traumatology

Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections

(2021) Chung-Kai Sun et al.   Polymers

Local treatment of experimental mandibular osteomyelitis with an injectable biomimetic gentamicin hydrogel using a new rabbit model

(2021) Ahmed Maher Eltawila et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

(2021) Deepa Garg et al.   ACS Biomaterials-Science & Engineering

Recent Applications of Dual-Stimuli Responsive Chitosan Hydrogel Nanocomposites as Drug Delivery Tools

(2021) Pumtiwitt C. McCarthy et al.   MOLECULES

In situ-formed adhesive hyaluronic acid hydrogel with prolonged amnion-derived conditioned medium release for diabetic wound repair

(2021) Yiqing Zhang et al.   CARBOHYDRATE POLYMERS

Transglutaminases: part I—origins, sources, and biotechnological characteristics

(2020) Lovaine Duarte et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant

(2020) Yuan Li et al.   ACS Nano

BMP-2 and hMSC dual delivery onto 3D printed PLA-Biogel scaffold for critical-size bone defect regeneration in rabbit tibia

(2020) Shi Huan Han et al.   Biomedical Materials

Injectable Chitosan-Based Thermosensitive Hydrogel/Nanoparticle-Loaded System for Local Delivery of Vancomycin in the Treatment of Osteomyelitis

(2020) Jin Tao et al.   International Journal of Nanomedicine

Injectable BMP ‐2 gene‐activated scaffold for the repair of cranial bone defect in mice

(2020) Kai Sun et al.   Stem Cells Translational Medicine

The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel to Treat Patients With Knee Megaprosthesis Infection Requiring “Debridement Antibiotics and Implant Retention” and Soft Tissue Coverage as Salvage Therapy

(2020) Tristan Ferry et al.   Frontiers in Medicine

4D Printing: A Review on Recent Progresses

(2020) Honghui Chu et al.   Micromachines

Chitosan-based drug delivery systems: From synthesis strategy to osteomyelitis treatment – A review

(2020) Fenghua Tao et al.   CARBOHYDRATE POLYMERS

Recent Progress on the Synthesis and Biomedical Properties of Natural Biopolymer Composites

(2020) Shan Liu et al.   CURRENT MEDICINAL CHEMISTRY

Single‐stage revision of MRSA orthopedic device‐related infection in sheep with an antibiotic‐loaded hydrogel

(2020) Andrew L. Foster et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transglutaminase-mediated crosslinking of a host defence peptide derived from human apolipoprotein B and its effect on the peptide antimicrobial activity

(2020) Eliana Dell'Olmo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Temperature-responsive PNDJ hydrogels provide high and sustained antimicrobial concentrations in surgical sites

(2019) Derek J. Overstreet et al.   Drug Delivery and Translational Research

Advancing Frontiers in Bone Bioprinting

(2019) Nureddin Ashammakhi et al.   Advanced Healthcare Materials

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection

(2019) Johanna M. Sweere et al.   SCIENCE

A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy

(2019) Peng Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection

(2019) Amy Aldrich et al.   ACS Applied Materials & Interfaces

2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions

(2019) Edward M. Schwarz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

(2019) Nicole E. Putnam et al.   PLoS Pathogens

Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects

(2019) Christopher T. Johnson et al.   Science Advances

Mini-review: efficacy of lytic bacteriophages on multispecies biofilms

(2019) Legesse Geredew Kifelew et al.   BIOFOULING

Hydrogel Nanospike Patch as a Flexible Anti-Pathogenic Scaffold for Regulating Stem Cell Behavior

(2019) Sunho Park et al.   ACS Nano

Engineering Biocoatings To Prolong Drug Release from Supraparticles

(2019) Yutian Ma et al.   BIOMACROMOLECULES

Biological Response to Macroporous Chitosan-Agarose Bone Scaffolds Comprising Mg- and Zn-Doped Nano-Hydroxyapatite

(2019) Paulina Kazimierczak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacteriophage delivering hydrogels reduce biofilm formation in vitro and infection in vivo

(2019) James A. Wroe et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

In Situ Gelling Hydrogel with Anti-Bacterial Activity and Bone Healing Property for Treatment of Osteomyelitis

(2019) Sun Woo Jung et al.   Tissue Engineering and Regenerative Medicine

Applications of chitin and chitosan nanofibers in bone regenerative engineering

(2019) Fenghua Tao et al.   CARBOHYDRATE POLYMERS

Chitosan as an environment friendly biomaterial – a review on recent modifications and applications

(2019) Prasanna S. Bakshi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection

(2019) Leah H. Cobb et al.   PLoS One

Local application of a gentamicin-loaded hydrogel early after injury is superior to peri-operative systemic prophylaxis in a rabbit open fracture model

(2019) A Vallejo et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Sustained Release of BMP-2 from Porous Particles with Leaf-Stacked Structure for Bone Regeneration

(2018) Ho Yong Kim et al.   ACS Applied Materials & Interfaces

Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite

(2018) Thai Thanh Hoang Thi et al.   Acta Biomaterialia

Mussel-inspired dual-functional PEG hydrogel inducing mineralization and inhibiting infection in maxillary bone reconstruction

(2018) Huiyong Xu et al.   Materials Science & Engineering C-Materials for Biological Applications

Thermogelling Platform for Baicalin Delivery for Versatile Biomedical Applications

(2018) Mohamed Haider et al.   MOLECULAR PHARMACEUTICS

A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia

(2018) Avanish K. Varshney et al.   PLoS One

Hydrogel delivery of lysostaphin eliminates orthopedic implant infection byStaphylococcus aureusand supports fracture healing

(2018) Christopher T. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress and Promise of Nitric Oxide-Releasing Platforms

(2018) Tao Yang et al.   Advanced Science

Antibacterial and immunogenic behavior of silver coating on additively manufactured porous titanium

(2018) M. Croes et al.   Acta Biomaterialia

Treatment Algorithms for Chronic Osteomyelitis

(2018) Gerhard Walter et al.   Deutsches Arzteblatt International

Antibiotic coated hinged threaded rods in the treatment of infected nonunions and intramedullary long bone infections

(2018) Jae-Woo Cho et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Sustained Release of Antimicrobial Peptide from Self-Assembling Hydrogel Enhanced Osteogenesis

(2018) Guoli Yang et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Coatings as the useful drug delivery system for the prevention of implant-related infections

(2018) Chenhao Pan et al.   Journal of Orthopaedic Surgery and Research

Surface treatment strategies to combat implant-related infection from the beginning

(2018) Minqi Wang et al.   Journal of Orthopaedic Translation

Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection

(2018) Ge Gao et al.   BIOMATERIALS

Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction

(2018) Mahla Poudineh et al.   NANO LETTERS

Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants

(2018) Carlos Mas-Moruno et al.   Advanced Healthcare Materials

A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants

(2018) Ryan P. Trombetta et al.   mSphere

Application of Extrusion-Based Hydrogel Bioprinting for Cartilage Tissue Engineering

(2017) Fu You et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

(2017) Karen L de Mesy Bentley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms

(2017) Parish P. Sedghizadeh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Viable bacteria persist on antibiotic spacers following two-stage revision for periprosthetic joint infection

(2017) Dongzhu Ma et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Liposome-based drug co-delivery systems in cancer cells

(2017) Sepideh Zununi Vahed et al.   Materials Science & Engineering C-Materials for Biological Applications

Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue

(2017) Batzaya Byambaa et al.   Advanced Healthcare Materials

Hyaluronic Acid Promotes the Osteogenesis of BMP-2 in an Absorbable Collagen Sponge

(2017) Hairong Huang et al.   Polymers

The immobilization of antibiotic-loaded polymeric coatings on osteoarticular Ti implants for the prevention of bone infections

(2017) Dan Li et al.   Biomaterials Science

Metal Ion Coordination Polymer-Capped pH-Triggered Drug Release System on Titania Nanotubes for Enhancing Self-antibacterial Capability of Ti Implants

(2017) Tingting Wang et al.   ACS Biomaterials-Science & Engineering

Metal Ion Coordination Polymer-Capped pH-Triggered Drug Release System on Titania Nanotubes for Enhancing Self-antibacterial Capability of Ti Implants

(2017) Tingting Wang et al.   ACS Biomaterials Science & Engineering

Bad to the Bone: On In Vitro and Ex Vivo Microbial Biofilm Ability to Directly Destroy Colonized Bone Surfaces without Participation of Host Immunity or Osteoclastogenesis

(2017) Adam Junka et al.   PLoS One

Injectable gentamicin-loaded thermo-responsive hyaluronic acid derivative prevents infection in a rabbit model

(2016) Gert-Jan A. ter Boo et al.   Acta Biomaterialia

Biomaterials approaches to treating implant-associated osteomyelitis

(2016) Jason A. Inzana et al.   BIOMATERIALS

Systemic and Local Administration of Antimicrobial and Cell Therapies to Prevent Methicillin-ResistantStaphylococcus epidermidis-Induced Femoral Nonunions in a Rat Model

(2016) Arianna B. Lovati et al.   MEDIATORS OF INFLAMMATION

Diamond-coated ‘black silicon’ as a promising material for high-surface-area electrochemical electrodes and antibacterial surfaces

(2016) P. W. May et al.   Journal of Materials Chemistry B

Antimicrobial delivery systems for local infection prophylaxis in orthopedic- and trauma surgery

(2015) Gert-Jan A. ter Boo et al.   BIOMATERIALS

Local antibiotic therapy strategies in orthopaedic trauma: Practical tips and tricks and review of the literature

(2015) Mark E. Hake et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Local Bismuth Thiols Potentiate Antibiotics and Reduce Infection in a Contaminated Open Fracture Model

(2015) Jowan G. Penn-Barwell et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Interfacing Inorganic Nanowire Arrays and Living Cells for Cellular Function Analysis

(2015) Minsuk Kwak et al.   Small

Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus

(2015) Vilasack Thammavongsa et al.   VACCINE

Molecular Characterization ofStaphylococcus aureusfrom Surgical Site Infections in Orthopedic Patients in an Orthopedic Trauma Clinical Medical Center in Shanghai

(2015) Fei-Fei Gu et al.   Surgical Infections

Retrospective evaluation of the incidence of early periprosthetic infection with silver-treated endoprostheses in high-risk patients

(2015) H. Wafa et al.   Bone & Joint Journal

Targeting Methicillin-Resistant Staphylococcus aureus with Short Salt-Resistant Synthetic Peptides

(2014) Mohamed F. Mohamed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

Where does a Staphylococcus aureus vaccine stand?

(2014) V.G. Fowler et al.   CLINICAL MICROBIOLOGY AND INFECTION

Local Gentamicin Delivery From Resorbable Viscous Hydrogels Is Therapeutically Effective

(2014) Derek Overstreet et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Does Implant Coating With Antibacterial-Loaded Hydrogel Reduce Bacterial Colonization and Biofilm Formation in Vitro?

(2014) Lorenzo Drago et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Preparation and characteristics of thermoresponsive gel of minocycline hydrochloride and evaluation of its effect on experimental periodontitis models

(2014) Hong Ruan et al.   DRUG DELIVERY

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

(2014) Katrien Forier et al.   JOURNAL OF CONTROLLED RELEASE

Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins ofStaphylococcus aureuswith a single human monoclonal antibody

(2014) Harald Rouha et al.   mAbs

A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis

(2014) C. L. Romanò et al.   Bone & Joint Journal

The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis

(2014) J. Y. Ferguson et al.   Bone & Joint Journal

The challenge of methicillin resistant staphylococcal infection after total hip replacement

(2014) M. C. Parry et al.   Bone & Joint Journal

Biofilms and chronic wound inflammation

(2014) R.D. Wolcott et al.   Journal of Wound Care

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial

(2014) D.D. Rhoads et al.   Journal of Wound Care

Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model

(2013) Patrick P. Spicer et al.   Acta Biomaterialia

Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance

(2013) Victoria J. Savage et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biophysical Model of Bacterial Cell Interactions with Nanopatterned Cicada Wing Surfaces

(2013) Sergey Pogodin et al.   BIOPHYSICAL JOURNAL

Staphylococcus aureus toxins

(2013) Michael Otto   CURRENT OPINION IN MICROBIOLOGY

Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics

(2013) Honglue Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel bone cement impregnated with silver–tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties

(2013) Polina Prokopovich et al.   International Journal of Nanomedicine

Medicated hydrogels of hyaluronic acid derivatives for use in orthopedic field

(2013) Giovanna Pitarresi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficacy of antibacterial-loaded coating in an in vivo model of acutely highly contaminated implant

(2013) Gianluca Giavaresi et al.   INTERNATIONAL ORTHOPAEDICS

Bacteriophage Therapy in Implant-Related Infections

(2013) Cengiz Yilmaz et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Targeting Macrophage Activation for the Prevention and Treatment of Staphylococcus aureus Biofilm Infections

(2013) M. L. Hanke et al.   JOURNAL OF IMMUNOLOGY

Recent lessons for the management of bone and joint infections

(2013) Sheldon L. Kaplan   JOURNAL OF INFECTION

Controlled release of gentamicin from gelatin/genipin reinforced beta-tricalcium phosphate scaffold for the treatment of osteomyelitis

(2013) Tianyi Wu et al.   Journal of Materials Chemistry B

Polydopamine-Induced Tooth Remineralization

(2012) Yun-Zhi Zhou et al.   ACS Applied Materials & Interfaces

Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics

(2012) Aleksandar F. Radovic-Moreno et al.   ACS Nano

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review

(2012) Sepideh Elyasi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Incidence and predictors of acute kidney injury associated with intravenous polymyxin B therapy

(2012) Christine J. Kubin et al.   JOURNAL OF INFECTION

Microbiological and pharmacological tests on new antibiotic-loaded PMMA-based composites for the treatment of osteomyelitis

(2012) Gianluca Giavaresi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Oral T4-like phage cocktail application to healthy adult volunteers from Bangladesh

(2012) Shafiqul Alam Sarker et al.   VIROLOGY

Antibacterial Performance of Polydopamine-Modified Polymer Surfaces Containing Passive and Active Components

(2011) Tadas S. Sileika et al.   ACS Applied Materials & Interfaces

Differential Effect of Common Ligands and Molecular Oxygen on Antimicrobial Activity of Silver Nanoparticles versus Silver Ions

(2011) Zong-Ming Xiu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

‘To bead or not to bead?’ Treatment of osteomyelitis and prosthetic joint-associated infections with gentamicin bead chains

(2011) Roos E. Barth et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Dual-Purpose Bone Grafts Improve Healing and Reduce Infection

(2011) Scott A Guelcher et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles

(2010) Kuo-Ti Peng et al.   BIOMATERIALS

Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds

(2010) Erin Yiling Teo et al.   BIOMATERIALS

Staphylococcus aureusSmall‐Colony Variants Are Adapted Phenotypes for Intracellular Persistence

(2010) Lorena Tuchscherr et al.   JOURNAL OF INFECTIOUS DISEASES

Antibiotic-Loaded Allograft Decreases the Rate of Acute Deep Wound Infection After Spinal Fusion in Cerebral Palsy

(2010) Battugs Borkhuu et al.   SPINE

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Targeted Immunotherapy for Staphylococcal Infections

(2009) Michael Otto   BIODRUGS

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

(2009) Yogeshkumar Malam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insights into the Mode of Action of Chitosan as an Antibacterial Compound

(2008) D. Raafat et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Lysostaphin: an antistaphylococcal agent

(2008) Jaspal K. Kumar   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Periprosthetic Joint Infection: The Incidence, Timing, and Predisposing Factors

(2008) Luis Pulido et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections

(2008) P. Meers et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY