期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.865250
关键词
hydrogel; osteomyelitis; infection; drug-loaded materials; in vivo
资金
- National Natural Science Foundation of China [81972086, 81672196]
- Shanghai Rising Stars of Medical Talent Youth Development Program (Youth Medical Talents-Specialist Program) [2019-72]
- National Key Research and Development Project of China [2020YFC1107500, 2020YFC1107503]
- Technology Innovation Action Plan Key Project of Shanghai Science and Technology Commission [19411962800]
- Clinical Scientific innovation and Cultivation Fund of Renji Hospital Affiliated School of Medicine, Shanghai Jiaotong University [PY2018-I-02]
- RENJI-NSFC Advancing Targeted Projects [RJTJ-JX-005]
This review article discusses the use of hydrogel-based strategies for the treatment of osteomyelitis. These strategies possess unique properties such as loadable, implantable, injectable, printable, degradable, and responsive to stimuli, which have the potential to improve biological properties including antimicrobial effects, osteo-induction, and controlled drug delivery.
Osteomyelitis (OM), a devastating disease caused by microbial infection of bones, remains a major challenge for orthopedic surgeons. Conventional approaches for prevention and treatment of OM are unsatisfactory. Various alternative strategies have been proposed, among which, hydrogel-based strategies have demonstrated potential due to their unique properties, including loadable, implantable, injectable, printable, degradable, and responsive to stimuli. Several protocols, including different hydrogel designs, selection of antimicrobial agent, co-administration of bone morphogenetic protein 2 (BMP 2), and nanoparticles, have been shown to improve the biological properties, including antimicrobial effects, osteo-induction, and controlled drug delivery. In this review, we describe the current and future directions for designing hydrogels and their applications to improve the biological response to OM in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据