Hydrogel delivery of lysostaphin eliminates orthopedic implant infection byStaphylococcus aureusand supports fracture healing

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

(2017) Hollie Hathaway et al.   JOURNAL OF CONTROLLED RELEASE

Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm-related infections

(2017) S. Hogan et al.   JOURNAL OF HOSPITAL INFECTION

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017

(2017) Sandra I. Berríos-Torres et al.   JAMA Surgery

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

(2017) Jessica D. Weaver et al.   Science Advances

Activity of Tedizolid in Methicillin-Resistant Staphylococcus epidermidis Experimental Foreign Body-Associated Osteomyelitis

(2016) Kyung-Hwa Park et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

(2016) Jordan Raphel et al.   BIOMATERIALS

Biomaterials approaches to treating implant-associated osteomyelitis

(2016) Jason A. Inzana et al.   BIOMATERIALS

Integrin-specific hydrogels functionalized with VEGF for vascularization and bone regeneration of critical-size bone defects

(2016) José R. García et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Antimicrobial delivery systems for local infection prophylaxis in orthopedic- and trauma surgery

(2015) Gert-Jan A. ter Boo et al.   BIOMATERIALS

A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery

(2015) Jason A. Inzana et al.   BONE

Depletion of T Cell Epitopes in Lysostaphin Mitigates Anti-Drug Antibody Response and Enhances Antibacterial Efficacy In Vivo

(2015) Hongliang Zhao et al.   CHEMISTRY & BIOLOGY

Prevalence of Total Hip and Knee Replacement in the United States

(2015) Hilal Maradit Kremers et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Antibacterial and Antibiofilm Surfaces through Polydopamine-Assisted Immobilization of Lysostaphin as an Antibacterial Enzyme

(2015) Gil Yeroslavsky et al.   LANGMUIR

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance

(2015) Kristina Blazanovic et al.   Molecular Therapy-Methods & Clinical Development

Scaffold-based Anti-infection Strategies in Bone Repair

(2014) Christopher T. Johnson et al.   ANNALS OF BIOMEDICAL ENGINEERING

Targeting Methicillin-Resistant Staphylococcus aureus with Short Salt-Resistant Synthetic Peptides

(2014) Mohamed F. Mohamed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype

(2014) Asha Shekaran et al.   BONE

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Lysostaphin-Coated Titan-Implants Preventing Localized Osteitis by Staphylococcus aureus in a Mouse Model

(2014) Ceylan D. Windolf et al.   PLoS One

Biofilms and chronic wound inflammation

(2014) R.D. Wolcott et al.   Journal of Wound Care

The future of biologic coatings for orthopaedic implants

(2013) Stuart B. Goodman et al.   BIOMATERIALS

Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes

(2013) Edward A. Phelps et al.   BIOMATERIALS

Anti-staphylococcal activities of lysostaphin and LytM catalytic domain

(2012) Izabela Sabala et al.   BMC MICROBIOLOGY

Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery

(2011) Edward A. Phelps et al.   ADVANCED MATERIALS

Lysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications

(2011) Jianjun Miao et al.   BIOMATERIALS

Mouse model of chronic post-arthroplasty infection: Noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study

(2011) Jonathan R. Pribaz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Addition of Lysostaphin Dramatically Improves Survival, Protects Porcine Biomesh from Infection, and Improves Graft Tensile Shear Strength

(2011) Igor Belyansky et al.   JOURNAL OF SURGICAL RESEARCH

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model System

(2009) W. Fu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Analysis of Biofilm Formation by Rapidly and Slowly Growing Nontuberculous Mycobacteria

(2009) M. M. Williams et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice

(2009) John F. Kokai-Kun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lysostaphin: an antistaphylococcal agent

(2008) Jaspal K. Kumar   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Medical biofilms

(2008) James D. Bryers   BIOTECHNOLOGY AND BIOENGINEERING