From Bench to Bed: The Current Genome Editing Therapies for Glaucoma
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
From Bench to Bed: The Current Genome Editing Therapies for Glaucoma
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-05-16
DOI
10.3389/fcell.2022.879957
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities—A review
- (2022) Inas F. Aboobakar et al. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial
- (2022) Christopher Kai Shun Leung et al. Trials
- Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2
- (2022) Lu Yin et al. Bioengineered
- Glaucoma in Adults—Screening, Diagnosis, and Management
- (2021) Joshua D. Stein et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- miRNAs and Müller Glia Reprogramming During Retina Regeneration
- (2021) Gregory J. Konar et al. Frontiers in Cell and Developmental Biology
- Design of synthetic promoters for controlled expression of therapeutic genes in retinal pigment epithelial cells
- (2021) Yusuf B. Johari et al. BIOTECHNOLOGY AND BIOENGINEERING
- Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
- (2021) Puya Gharahkhani et al. Nature Communications
- Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
- (2021) James K. Nuñez et al. CELL
- Apical CLC‐2 in retinal pigment epithelium is crucial for survival of the outer retina
- (2021) Christin Hanke‐Gogokhia et al. FASEB JOURNAL
- Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
- (2021) Benjamin R. Thomson et al. Nature Communications
- Intraocular Pressure–Related Events After Anti–Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion
- (2021) Ahmad A. Aref et al. JAMA Ophthalmology
- Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9
- (2020) Jiahui Wu et al. MOLECULAR THERAPY
- Transplantation of iPSC-TM stimulates division of trabecular meshwork cells in human eyes
- (2020) Wei Zhu et al. Scientific Reports
- Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
- (2020) Haibo Zhou et al. CELL
- Pharmacologic fibroblast reprogramming into photoreceptors restores vision
- (2020) Biraj Mahato et al. NATURE
- Dual Supramolecular Nanoparticle Vectors Enable CRISPR/Cas9‐Mediated Knockin of Retinoschisin 1 Gene—A Potential Nonviral Therapeutic Solution for X‐Linked Juvenile Retinoschisis
- (2020) Shih‐Jie Chou et al. Advanced Science
- Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy
- (2020) Divya Sinha et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial
- (2020) Flora Hui et al. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Effect of connective tissue growth factor gene editing using adeno-associated virus–mediated CRISPR–Cas9 on rabbit glaucoma filtering surgery outcomes
- (2020) Eun Jung Lee et al. GENE THERAPY
- Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy
- (2020) Najiha Rahman et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing
- (2020) C. Moses et al. Scientific Reports
- Antisense oligonucleotide- and CRISPR-Cas9-mediated rescue of mRNA splicing for a deep intronic CLRN1 mutation
- (2020) Anna-Lena Panagiotopoulos et al. Molecular Therapy-Nucleic Acids
- Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids
- (2020) Kirstin B. VanderWall et al. Stem Cell Reports
- Empowering Retinal Gene Therapy with a Specific Promoter for Human Rod and Cone ON-Bipolar Cells
- (2020) Elmar Carlos Hulliger et al. Molecular Therapy-Methods & Clinical Development
- Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia
- (2020) Seyedeh Zeinab Mirjalili Mohanna et al. Molecular Therapy-Methods & Clinical Development
- Liver injury increases incidence of HCC following AAV gene therapy in mice
- (2020) Dhwanil A. Dalwadi et al. MOLECULAR THERAPY
- Gene regulatory networks controlling vertebrate retinal regeneration
- (2020) Thanh Hoang et al. SCIENCE
- Gene Therapy Preserves Retinal Structure and Function in a Mouse Model of NMNAT1-Associated Retinal Degeneration
- (2020) Scott H. Greenwald et al. Molecular Therapy-Methods & Clinical Development
- Trinucleotide Repeat-Targeting dCas9 as a Therapeutic Strategy for Fuchs’ Endothelial Corneal Dystrophy
- (2020) Ziye Rong et al. Translational Vision Science & Technology
- Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
- (2020) Susie Suh et al. Nature Biomedical Engineering
- Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
- (2019) Morgan L. Maeder et al. NATURE MEDICINE
- Adeno-associated virus vector as a platform for gene therapy delivery
- (2019) Dan Wang et al. NATURE REVIEWS DRUG DISCOVERY
- Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9
- (2019) Laura Bohrer et al. Genes
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis
- (2019) Kang-Chieh Huang et al. Stem Cell Reports
- CRISPR-Cas9–mediated therapeutic editing of Rpe65 ameliorates the disease phenotypes in a mouse model of Leber congenital amaurosis
- (2019) Dong Hyun Jo et al. Science Advances
- Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina
- (2019) Tien-Chun Yang et al. Acta Biomaterialia
- The approved gene therapy drugs worldwide: from 1998 to 2019
- (2019) Cui-Cui Ma et al. BIOTECHNOLOGY ADVANCES
- Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation
- (2019) Hyun-Kyung Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of miR-21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush
- (2018) Hong-Jiang Li et al. NEUROPHARMACOLOGY
- Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization
- (2018) Manas R. Biswal et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor/tropomyosin-related kinase receptor-B signaling
- (2018) Andrew Osborne et al. Cell Death & Disease
- Somatic Gene Editing of GUCY2D by AAV-CRISPR/Cas9 Alters Retinal Structure and Function in Mouse and Macaque
- (2018) K. Tyler McCullough et al. HUMAN GENE THERAPY
- Non-Synonymous variants in Premelanosome Protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma
- (2018) Adrian A Lahola-Chomiak et al. HUMAN MOLECULAR GENETICS
- Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina
- (2017) Pavitra S. Ramachandran et al. HUMAN GENE THERAPY
- Glaucoma as a Metabolic Optic Neuropathy
- (2017) Pete A. Williams et al. JOURNAL OF GLAUCOMA
- Glaucoma
- (2017) Jost B Jonas et al. LANCET
- RNA targeting with CRISPR–Cas13
- (2017) Omar O. Abudayyeh et al. NATURE
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Identification of liver-specific enhancer–promoter activity in the 3′ untranslated region of the wild-type AAV2 genome
- (2017) Grant J Logan et al. NATURE GENETICS
- CRISPR-Cas9–based treatment of myocilin-associated glaucoma
- (2017) Ankur Jain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications
- (2017) Hongli Yang et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
- (2017) Pete A. Williams et al. SCIENCE
- In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
- (2017) Eunji Kim et al. Nature Communications
- Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells
- (2016) Joshua B. Black et al. Cell Stem Cell
- Defects in autophagy caused by glaucoma-associated mutations in optineurin
- (2016) Kapil Sirohi et al. EXPERIMENTAL EYE RESEARCH
- Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs
- (2016) R F Boyd et al. GENE THERAPY
- Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
- (2016) Tomokazu Souma et al. JOURNAL OF CLINICAL INVESTIGATION
- Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
- (2016) Carolin Anders et al. MOLECULAR CELL
- Genome Engineering Using Adeno-associated Virus: Basic and Clinical Research Applications
- (2016) Thomas Gaj et al. MOLECULAR THERAPY
- CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa
- (2016) Wen-Hsuan Wu et al. MOLECULAR THERAPY
- In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa
- (2016) Benjamin Bakondi et al. MOLECULAR THERAPY
- In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
- (2016) Keiichiro Suzuki et al. NATURE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
- (2016) Chiea Chuen Khor et al. NATURE GENETICS
- Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
- (2015) Jesse G. Zalatan et al. CELL
- Atoh7 promotes the differentiation of Müller cells-derived retinal stem cells into retinal ganglion cells in a rat model of glaucoma
- (2015) Wei-tao Song et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting
- (2015) D G Courtney et al. GENE THERAPY
- Functional analysis of optineurin and some of its disease-associated mutants
- (2015) Megha Bansal et al. IUBMB LIFE
- Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
- (2015) Antonia A. Dominguez et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics
- (2015) Stephane Belin et al. NEURON
- Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
- (2015) James W.B. Bainbridge et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neuroprotective therapies in glaucoma: II. Genetic nanotechnology tools
- (2015) Nafiseh Nafissi et al. Frontiers in Neuroscience
- Experimental scleral cross-linking increases glaucoma damage in a mouse model
- (2014) Elizabeth C. Kimball et al. EXPERIMENTAL EYE RESEARCH
- Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers
- (2014) Blanca Rojas et al. Journal of Neuroinflammation
- Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells
- (2014) Ignazio Maggio et al. Scientific Reports
- Epidemiology of glaucoma: what's new?
- (2013) Colin Cook et al. CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
- Regulation of Plasticity and Fibrogenic Activity of Trabecular Meshwork Cells by Rho GTPase Signaling
- (2013) Padmanabhan P. Pattabiraman et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Induction of retinal ganglion-like cells from fibroblasts by adenoviral gene delivery
- (2013) F. Meng et al. NEUROSCIENCE
- Association of CAV1/CAV2 Genomic Variants with Primary Open-Angle Glaucoma Overall and by Gender and Pattern of Visual Field Loss
- (2013) Stephanie J. Loomis et al. OPHTHALMOLOGY
- Conserved microRNA pathway regulates developmental timing of retinal neurogenesis
- (2013) A. La Torre et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atoh7 promotes the differentiation of retinal stem cells derived from Müller cells into retinal ganglion cells by inhibiting Notch signaling
- (2013) Wei-tao Song et al. Stem Cell Research & Therapy
- NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
- (2012) Travis L Dickendesher et al. NATURE NEUROSCIENCE
- Ocular gene delivery using lentiviral vectors
- (2011) K S Balaggan et al. GENE THERAPY
- Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
- (2011) Fang Sun et al. NATURE
- Neurog2 controls the leading edge of neurogenesis in the mammalian retina
- (2010) Robert B. Hufnagel et al. DEVELOPMENTAL BIOLOGY
- Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro
- (2008) Osamu Yamanaka et al. JAPANESE JOURNAL OF OPHTHALMOLOGY
- Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
- (2008) K. K. Park et al. SCIENCE
- Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular Meshwork
- (2007) Pranay D Khare et al. MOLECULAR THERAPY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started