A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera

(2021) Daming Zhou et al.   CELL

Baricitinib and dexamethasone for hospitalized patients with COVID-19

(2021) Leonard H. Calabrese et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity

(2021) Daisy A. Hoagland et al.   IMMUNITY

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

(2021) Dami A. Collier et al.   NATURE

SARS-CoV-2 evolution during treatment of chronic infection

(2021) Steven A. Kemp et al.   NATURE

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

(2021) Ivan O. Rosas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States

(2021) Tara Alpert et al.   CELL

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

(2021) Markus Hoffmann et al.   CELL

Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

(2021) Nicole L. Washington et al.   CELL

Innate immune and inflammatory responses to SARS-CoV-2: implications for COVID-19

(2021) Shea A. Lowery et al.   Cell Host & Microbe

Diverse Functional Autoantibodies in Patients with COVID-19

(2021) Eric Y. Wang et al.   NATURE

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

(2021) Delphine Planas et al.   NATURE MEDICINE

Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2

(2021) Chantal B. F. Vogels et al.   PLOS BIOLOGY

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection

(2021) Fiachra Humphries et al.   Science Immunology

Pharmacological activation of STING blocks SARS-CoV-2 infection

(2021) Minghua Li et al.   Science Immunology

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2

(2021) Parakkal Deepak et al.   ANNALS OF INTERNAL MEDICINE

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

(2021) Benjamin Israelow et al.   Science Immunology

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19

(2020) Ling Li et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Convalescent plasma therapy for B-cell depleted patients with protracted COVID-19 disease

(2020) Thomas Hueso et al.   BLOOD

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Real-time public health communication of local SARS-CoV-2 genomic epidemiology

(2020) Chaney C. Kalinich et al.   PLOS BIOLOGY

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

(2020) Bina Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

(2020) Teresa Aydillo et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

(2020) Ventura A. Simonovich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

(2019) Claire Vanpouille-Box et al.   NATURE REVIEWS DRUG DISCOVERY

Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses

(2019) Xiaodong Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

A minimal RNA ligand for potent RIG-I activation in living mice

(2018) Melissa M. Linehan et al.   Science Advances

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes

(2018) Melissa B. Uccellini et al.   Cell Reports

Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective

(2015) Pei-Hui Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

(2013) Marie-Line Goulet et al.   PLoS Pathogens

Anti-interferon-α neutralizing antibody is associated with nonresponse to pegylated interferon-α plus ribavirin in chronic hepatitis C

(2012) F. Matsuda et al.   JOURNAL OF VIRAL HEPATITIS

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL