Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT

(2016) Andrej Ďuriš et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12

(2016) Komal G. Lalwani et al.   TETRAHEDRON LETTERS

The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers

(2015) Cécile Santos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

BF3-Mediated cis-Selective Cycloaddition of O-Silyloxime with Alkenes

(2015) Nobuyoshi Morita et al.   JOURNAL OF ORGANIC CHEMISTRY

A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12

(2015) José-Luis Abad et al.   TETRAHEDRON LETTERS

Chelation controlled reduction of N-protected β-amino ketones toward the synthesis of HPA-12 and analogues

(2015) Shibin Chacko et al.   TETRAHEDRON-ASYMMETRY

Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors

(2014) Cécile Santos et al.   CHEMBIOCHEM

Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives

(2014) Essa M. Saied et al.   Chemistry-An Asian Journal

Synthesis of syn-1,3-Aminoalcohols via a Ru-Catalyzed N-Demethylative Rearrangement of Isoxazolidines and Its Application in a Three-Step Total Synthesis of HPA-12

(2014) Chuan-Zhi Yao et al.   ORGANIC LETTERS

Ruthenium-Catalyzed Asymmetric N-Demethylative Rearrangement of Isoxazolidines and Its Application in the Asymmetric Total Syntheses of (−)-(1R,3S)-HPA-12 and (+)-(1S,3R)-HPA-12

(2014) Zu-Feng Xiao et al.   ORGANIC LETTERS

Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins

(2014) Toshiyuki Yamaji et al.   TRAFFIC

Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis

(2013) Masaharu Ueno et al.   ORGANIC LETTERS

A biologically relevant ceramide fluorescent probe to assess the binding of potential ligands to the CERT transfer protein

(2013) Stéphanie Combemale et al.   RSC Advances

Ceramide Transfer Protein and Cancer

(2012) Luana Scheffer et al.   Anti-Cancer Agents in Medicinal Chemistry

Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques

(2012) Chiara Mencarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)

(2012) Toshihiko Sugiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereoselective Isoxazolidine Synthesis Via Copper-Catalyzed Alkene Aminooxygenation

(2012) Shuklendu D. Karyakarte et al.   JOURNAL OF ORGANIC CHEMISTRY

Sphingolipids in cancer

(2011) Hideki Furuya et al.   CANCER AND METASTASIS REVIEWS

Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein

(2011) Yutaka Amako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

(2011) Alvin J. X. Lee et al.   JOURNAL OF PATHOLOGY

Expedient and Practical Synthesis of CERT-Dependent Ceramide Trafficking Inhibitor HPA-12 and Its Analogues

(2011) Andrej Ďuriš et al.   ORGANIC LETTERS

Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

(2011) Cherilyn A. Elwell et al.   PLoS Pathogens

The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites

(2011) Isabelle Derré et al.   PLoS Pathogens

Crystal Structures of the CERT START Domain with Inhibitors Provide Insights into the Mechanism of Ceramide Transfer

(2009) Norio Kudo et al.   JOURNAL OF MOLECULAR BIOLOGY

Decreased Ceramide Transport Protein (CERT) Function Alters Sphingomyelin Production following UVB Irradiation

(2008) Alexandra Charruyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermolecular Cycloaddition ofN-Boranonitrone with Alkenes

(2008) Nobuyoshi Morita et al.   JOURNAL OF ORGANIC CHEMISTRY

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

(2008) H. Aizaki et al.   JOURNAL OF VIROLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA