3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening

The oncogenic landscape of the idiopathic pulmonary fibrosis: a narrative review

(2022) Giulia Maria Stella et al.   Translational Lung Cancer Research

CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis

(2021) Konstantin Tsoyi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reversed-engineered human alveolar lung-on-a-chip model

(2021) Di Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing

(2021) Jung-Hyun Kim et al.   Cell Death Discovery

A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it

(2021) Antonio Varone et al.   BIOMATERIALS

Theratyping cystic fibrosis in vitro in ALI-culture and organoid models generated from patient-derived nasal epithelial Conditionally Reprogrammed Stem Cells

(2021) Giovanni Sette et al.   EUROPEAN RESPIRATORY JOURNAL

Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip

(2021) Longlong Si et al.   Microbiology Spectrum

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip

(2021) Roberto Plebani et al.   Journal of Cystic Fibrosis

Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue

(2020) Roderick Harold Jan de Hilster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Applications and Approaches for 3D Precision-cut Lung Slices: Disease Modeling and Drug Discovery

(2020) Hani N Alsafadi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

(2020) Asres Berhan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

(2020) Ana Ivonne Vazquez‐Armendariz et al.   EMBO JOURNAL

Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration

(2020) Alena Moiseenko et al.   Cell Reports

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis

(2019) Matea Cedilak et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

(2019) Vahid Kheirollahi et al.   Nature Communications

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

(2019) Peng Wei et al.   Cell Death & Disease

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

(2019) Arbel Artzy-Schnirman et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Upregulation of PD-L1 expression in breast cancer cells through the formation of 3D multicellular cancer aggregates under different chemical and mechanical conditions

(2019) Shohreh Azadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

(2019) Moisés Selman et al.   CELLULAR SIGNALLING

Idiopathic Pulmonary Fibrosis: Best Practice in Monitoring and Managing a Relentless Fibrotic Disease

(2019) Wim A. Wuyts et al.   RESPIRATION

Caveolin-1–derived peptide limits development of pulmonary fibrosis

(2019) Amarnath Satheesh Marudamuthu et al.   Science Translational Medicine

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Use of 3D organoids and lung-on-a-chip methods to study lung development, regeneration and disease

(2018) Konstantinos Gkatzis et al.   EUROPEAN RESPIRATORY JOURNAL

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt

(2017) Alícia Giménez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro Models to Study Human Lung Development, Disease and Homeostasis

(2017) Alyssa J. Miller et al.   PHYSIOLOGY

Microbial volatile communication in human organotypic lung models

(2017) Layla J. Barkal et al.   Nature Communications

Role of pirfenidone in the management of pulmonary fibrosis

(2017) Keith Meyer et al.   Therapeutics and Clinical Risk Management

Reversal of the Transcriptome by Prostaglandin E2during Myofibroblast Dedifferentiation

(2016) Scott H. Wettlaufer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

Mechanosensing by the α6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

(2016) Huaping Chen et al.   Nature Communications

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

Novel drug targets for idiopathic pulmonary fibrosis

(2016) Giacomo Sgalla et al.   Expert Review of Respiratory Medicine

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

(2015) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Hydrogel: Preparation, characterization, and applications: A review

(2015) Enas M. Ahmed   Journal of Advanced Research

How does comorbidity influence survival in idiopathic pulmonary fibrosis?

(2014) Charlotte Hyldgaard et al.   RESPIRATORY MEDICINE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Animal Models of Fibrotic Lung Disease

(2013) Bethany B. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Idiopathic Pulmonary Fibrosis: Diagnosis and Epidemiology

(2012) Amy L. Olson et al.   CLINICS IN CHEST MEDICINE

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase 2 in Idiopathic Pulmonary Fibrosis

(2009) W. R. Coward et al.   MOLECULAR AND CELLULAR BIOLOGY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY