Journal
CELL REPORTS
Volume 33, Issue 12, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.108549
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Funding
- German Research Foundation (DFG) [KFO309 P7, SFB CRC1213]
- UKGM
- DZL
- DFG [KFO309 P7, SFB CRC1213, BE4443/14-1, BE4443/6-1, KFO309 P2/8, SFB1021 C05, SFB TR84 B9]
- First Affiliated Hospital of Wenzhou Medical University
- CPI (EXC 2026) [390649896]
- Wenzhou Medical University
- National Natural Science Foundation of China [81472601, 81570075, 81770074]
- Interventional Pulmonary Key Laboratory of Zhejiang Province
- Interventional Pulmonology Key Laboratory of Wenzhou City
- Interventional Pulmonology Innovation Subject of Zhejiang Province
- Zhejiang Provincial Natural Science Foundation [LZ15H010001]
- Zhejiang Provincial Science Technology Department Foundation [2015103253]
- National Key Research and Development Program of China [2016YFC1304000]
- UKGM (FOKOOPV)
- ILH
- CPI
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Tissue regeneration requires coordinated and dynamic remodeling of stem and progenitor cells and the surrounding niche. Although the plasticity of epithelial cells has been well explored in many tissues, the dynamic changes occurring in niche cells remain elusive. Here, we show that, during lung repair after naphthalene injury, a population of PDGFR(alpha)(+) cells emerges in the non-cartilaginous conducting airway niche, which is normally populated by airway smooth muscle cells (ASMCs). This cell population, which we term repair-supportive mesenchymal cells (RSMCs), is distinct from conventional ASMCs, which have previously been shown to contribute to epithelial repair Gene expression analysis on sorted lineage-labeled cells shows that RSMCs express low levels of ASMC markers, but high levels of the pro-regenerative marker Fgf10. Organoid co-cultures demonstrate an enhanced ability for RSMCs in supporting club-cell growth. Our study highlights the dynamics of mesenchymal cells in the airway niche and has implications for chronic airway-injury-associated diseases.
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