Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches

GAPDH is involved in the heme‐maturation of myoglobin and hemoglobin

(2022) Blair Tupta et al.   FASEB JOURNAL

NO rapidly mobilizes cellular heme to trigger assembly of its own receptor

(2022) Yue Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosis

(2022) Li Li et al.   Cell Death Discovery

Molecular chaperones and Parkinson's disease

(2021) Shenglan Hu et al.   NEUROBIOLOGY OF DISEASE

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

(2020) Hye-Kyung Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl

(2020) Margarita Marinova et al.   EXPERIMENTAL LUNG RESEARCH

Tracking cancer progression: from circulating tumor cells to metastasis

(2020) Francesc Castro-Giner et al.   Genome Medicine

The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice

(2020) Pavel Solopov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones

(2020) Elizabeth A. Sweeny et al.   Redox Biology

The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1

(2020) Alsamman M. Alsamman et al.   PLoS One

HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia

(2019) Alejandro A. Pezzulo et al.   JOURNAL OF CLINICAL INVESTIGATION

Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase

(2019) Arnab Ghosh et al.   FASEB JOURNAL

Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014

(2019) Yan Xiao et al.   CURRENT DRUG TARGETS

Heat-Shock Proteins in Neuroinflammation

(2019) Brigitta Dukay et al.   Frontiers in Pharmacology

The Multiple Roles and Therapeutic Potential of Molecular Chaperones in Prostate Cancer

(2019) Hoter et al.   Cancers

HSP70 and HSP90 in neurodegenerative diseases

(2019) Abha Gupta et al.   NEUROSCIENCE LETTERS

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor

(2018) Zhiyu Dai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells

(2018) Arnab Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice

(2018) Azirwan Guswanto et al.   International Journal for Parasitology-Drugs and Drug Resistance

Redox Aspects of Chaperones in Cardiac Function

(2018) Claudia Penna et al.   Frontiers in Physiology

Pathophysiology of Sickle Cell Disease

(2018) Prithu Sundd et al.   Annual Review of Pathology-Mechanisms of Disease

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intravascular hemolysis and the pathophysiology of sickle cell disease

(2017) Gregory J. Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Picky Hsp90—Every Game with Another Mate

(2017) Martina Radli et al.   MOLECULAR CELL

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

(2017) Yu Zheng et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis

(2016) Aaron R. Froese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Beta Subunit of Hemoglobin (HBB2/HBB) Suppresses Neuroblastoma Growth and Metastasis

(2016) Shelly Maman et al.   CANCER RESEARCH

Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors

(2016) Yen Chin Koay et al.   CHEMISTRY-A EUROPEAN JOURNAL

Epidemiology and survival of idiopathic pulmonary fibrosis from national data in Canada

(2016) Robert B. Hopkins et al.   EUROPEAN RESPIRATORY JOURNAL

The lived experience with idiopathic pulmonary fibrosis: a qualitative study

(2016) Dorthe Overgaard et al.   EUROPEAN RESPIRATORY JOURNAL

Amplified canonical transforming growth factor-β signallingviaheat shock protein 90 in pulmonary fibrosis

(2016) Zaneta Sibinska et al.   EUROPEAN RESPIRATORY JOURNAL

The Potential of sGC Modulators for the Treatment of Age-Related Fibrosis: A Mini-Review

(2016) Peter Sandner et al.   GERONTOLOGY

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

(2016) Arnab Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension

(2016) Guo-Kun Wang et al.   Oncotarget

The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery

(2016) Yunbin Xu et al.   Scientific Reports

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

High-level expression of Hsp90β is associated with poor survival in resectable non-small-cell lung cancer patients

(2015) Seok-Hyun Kim et al.   HISTOPATHOLOGY

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

(2015) Khanh Do et al.   INVESTIGATIONAL NEW DRUGS

Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism

(2015) Maria C. Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone function and mechanism of small heat-shock proteins

(2014) X. Fu   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (Review)

(2014) Zuzana Sol�rov� et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy

(2014) XIAOXIA WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

(2014) Arnab Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperoning parasitism: the importance of molecular chaperones in pathogen virulence

(2014) UTPAL TATU et al.   PARASITOLOGY

Selective targeting of the stress chaperome as a therapeutic strategy

(2014) Tony Taldone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Repurposing Strategy for Hsp90 Inhibitors Demonstrates Their Potency against Filarial Nematodes

(2014) Victoria Gillan et al.   PLoS Neglected Tropical Diseases

FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function

(2013) J. C. H. Byon et al.   BLOOD

Hsp90 inhibitors in breast cancer: A systematic review

(2013) Flora Zagouri et al.   BREAST

A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non-Small Cell Lung Cancer

(2013) M. A. Socinski et al.   CLINICAL CANCER RESEARCH

Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?

(2013) Subhankar Paul et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

(2013) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

(2013) Ayesha A. Shafi et al.   PHARMACOLOGY & THERAPEUTICS

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus

(2013) Ron Geller et al.   PLoS One

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

(2013) Juan Carlos Pizarro et al.   PLoS Neglected Tropical Diseases

Structure, Function and Regulation of the Hsp90 Machinery

(2013) Johannes Buchner et al.   Biomedical Journal

Hsp90: Still a viable target in prostate cancer

(2012) Margaret M. Centenera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ferruccio Ritossa’s scientific legacy 50 years after his discovery of the heat shock response: a new view of biology, a new society, and a new journal

(2012) Antonio De Maio et al.   CELL STRESS & CHAPERONES

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

NOS-2 signaling and cancer therapy

(2012) Ka Bian et al.   IUBMB LIFE

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial heme: an exit strategy at last

(2012) Mark D. Fleming et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Hsp90 Inhibitors

(2012) Rathi N. Pillai et al.   Journal of Thoracic Oncology

Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators

(2012) Neal L. Millar et al.   MEDIATORS OF INFLAMMATION

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Protein 90 Inhibitors as Therapeutic Agents

(2012) Isabel Gomez-Monterrey et al.   Recent Patents on Anti-Cancer Drug Discovery

Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60–2770, are not dependent on endogenous nitric oxide or reduced heme

(2011) Edward A. Pankey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

(2011) Feng Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide metabolism in asthma pathophysiology

(2011) Sudakshina Ghosh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quality control and fate determination of Hsp90 client proteins

(2011) Maria A. Theodoraki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

(2011) Jeffery D Eskew et al.   BMC CANCER

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process

(2011) Arnab Ghosh et al.   FASEB JOURNAL

Regulation of asthmatic airway relaxation by estrogen and heat shock protein 90

(2011) S. Intapad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Substrate Binding Drives Large-Scale Conformational Changes in the Hsp90 Molecular Chaperone

(2011) Timothy O. Street et al.   MOLECULAR CELL

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

(2010) Patrick Fadden et al.   CHEMISTRY & BIOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression and Functional Regulation of Myoglobin in Epithelial Cancers

(2009) Simona Emilia Flonta et al.   AMERICAN JOURNAL OF PATHOLOGY

Trafficking of Heme and Porphyrins in Metazoa

(2009) Scott Severance et al.   CHEMICAL REVIEWS

Update on Hsp90 Inhibitors in Clinical Trial

(2009) Y. Kim et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A conserved haem redox and trafficking pathway for cofactor attachment

(2009) Cynthia L Richard-Fogal et al.   EMBO JOURNAL

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

Discovery of the nitric oxide signaling pathway and targets for drug development

(2009) Nathan et al.   Frontiers in Bioscience-Landmark

To fold or not to fold: modulation and consequences of Hsp90 inhibition

(2009) Laura B Peterson et al.   Future Medicinal Chemistry

Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/Disulfide Redox Switch That Responds to the Cellular Redox State

(2009) Li Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein

(2009) S. Fabio Falsone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

(2009) Byoung Heon Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY

Mechanisms of heme iron absorption: Current questions and controversies

(2008) Adrian R West et al.   WORLD JOURNAL OF GASTROENTEROLOGY