Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

Soluble guanylate cyclase modulators blunt hyperoxia effects on calcium responses of developing human airway smooth muscle

(2015) Rodney D. Britt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

(2014) Arnab Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asthma: pathogenesis and novel drugs for treatment

(2014) J. T. Olin et al.   BMJ-British Medical Journal

The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators

(2013) Markus Follmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes

(2013) Vijay Kumar et al.   BIOCHEMISTRY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Heme-assistedS-Nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide

(2012) Nathaniel B. Fernhoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Haem-Oxidized Soluble Guanylyl Cyclase with BAY 60-2770 in Human Platelets Lead to Overstimulation of the Cyclic GMP Signaling Pathway

(2012) Camila B. Mendes-Silverio et al.   PLoS One

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

(2012) A. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-027 Inhibits IgE-mediated passive sensitization bronchoconstriction and acts as a histamine and serotonin antagonist in human airways

(2011) Philip R. Cooper et al.   ALLERGY AND ASTHMA PROCEEDINGS

Formoterol and salmeterol induce a similar degree of β2-adrenoceptor tolerance in human small airways but via different mechanisms

(2011) PR Cooper et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β2-adrenoceptors and exacerbates lung inflammation in mice

(2011) Rui Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, at-Risk Phenotype among Patients with Asthma

(2010) Raed A. Dweik et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

(2010) Syed Mohsin Waheed et al.   FREE RADICAL BIOLOGY AND MEDICINE

Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: A blood-borne cellular envoy for lung eosinophilia

(2010) Kewal Asosingh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation

(2009) Philip R. Cooper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

S-Nitrosoglutathione Reductase

(2009) Loretta G. Que et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

(2009) Joachim Mittendorf et al.   ChemMedChem

Polymorphism of theADRB2Gene and Response to Inhaled Beta- agonists in Children with Asthma: A Meta-analysis

(2009) Yaron Finkelstein et al.   JOURNAL OF ASTHMA

Mouse models of allergic asthma: acute and chronic allergen challenge

(2008) A. T. Nials et al.   Disease Models & Mechanisms

Steroids completely reverse albuterol-induced β 2 -adrenergic receptor tolerance in human small airways

(2008) Philip R. Cooper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model

(2008) Sofia Jonasson et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The discovery of nitric oxide and its role in vascular biology

(2006) S Moncada et al.   BRITISH JOURNAL OF PHARMACOLOGY